protein kinase C
Atypical protein kinase C zeta: potential player in cell survival and cell migration of ovarian cancer.
... a protein belonging to the atypical subclass of the protein kinase C family of ser- ine/threonine kinases that has been implicated in the regulation of cellular transformation and ...
17
Redundant role of protein kinase C delta and epsilon during mouse embryonic development.
... Protein Kinase C delta and epsilon are mediators of important cellular events, such as cell proliferation, migration or ...either Protein Kinase C delta or epsilon are viable and ...
13
Comparison of the involvement of protein kinase C in agonist-induced contractions in mouse aorta and corpus cavernosum
... Protein kinase C (PKC) is involved in the regulation of vascular smooth muscle contraction. However, the role of PKC in erectile function is poorly understood. This study investigated whether PKC ...
6
Differential regulation of cysteinyl leukotriene receptor signaling by protein kinase C in human mast cells.
... Protein kinase C (PKC) refers to a family of phospholipid- dependent serine/threonine protein kinases that are activated by a number of extracellular stimuli including growth factors, ...
8
Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε.
... novel protein kinase C’s (PKCh, PKCe, PKCd, and PKCg) ...the c-jun N-terminal kinase (JNK) to inhibit insulin signalling through this inflammatory stress kinase ...
16
Effect of Bothrops alternatus snake venom on macrophage phagocytosis and superoxide production: participation of protein kinase C
... activate protein kinase C (PKC) and induce “inside- out” signaling to integrin receptors ...binding protein Rap1 and the actin-binding protein talin (47, ...
12
Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells.
... Our results are in contrast to previous investigations, which have suggested a permissive role of PKCh in the development of Th17 responses and autoimmunity [31][32][33]. According to these authors, PKCh is required for ...
11
Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor
... 6 C. Protein concentrations were deter- ...6 C for 5 ...6 C with the primary antibodies (rabbit polyclonal to MIF, ...the protein levels of glycer- aldehyde 3-phosphate dehydrogenase ...
6
AMP-activated protein kinase as a target for pathogens: Friends or foes?
... the protein kinase B (PKB)/ (AKT) pathway to phosphorylate AMPK at Ser485, resulting in the inhibition of AMPK ...membrane protein 1 (LMP1) oncogenic protein inhibits the activity of AMPK ...
23
Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and increases matrix metalloproteinase-9 expression in a PKC- and Rho kinase-dependent manner
... of protein kinase C (GF109203X, 5 µM) or of Rho kinase (Y-27632, 15 µM), but not with inhibitors of phosphoinositide 3-kinase (wortmannin, 200 nM), tyrosine kinases (genistein, 100 µM) ...
8
Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila.
... Protein kinase signaling cascades control most aspects of cellular ...signaling protein kinases are the targets of most available ...of protein kinases for their ability to increase Drosophila ...
12
Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.
... the protein kinase activity has long been questioned due to its Mn 2+ dependency and lack of in vivo ...3-K protein kinase activity is deregulated in ...vitro protein kinase ...
8
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.
... Given the multifunctional role of cAMP in cytoskeletal regulation and cell migration, we tested the cAMP-raising agents forskolin and 8-Br-cAMP. Both stimuli partly mimicked LPA in inhibiting the basal migration rate of ...
10
HIV-1 activates macrophages independent of Toll-like receptors.
... were washed twice with phosphate-buffered saline (PBS), pH 7.4, and immediately lysed in ice-cold lysis buffer (1% Triton X-100, 2 mM Tris-HCl, 150 mM NaCl, 5 mM EDTA, 1 mM DTT, 1 mM NaF, 1mM Sodium Orthovanadate, 1 ...
15
The Kinome of Pacific Oyster Crassostrea gigas, Its Expression during Development and in Response to Environmental Factors.
... suppressing protein functions and for increasing the prote- ome functional diversity ...change protein properties either by proteolytic cleavage or by addition of a modifying group to one or several amino ...
24
Identification of Casein Kinase 1, Casein Kinase 2, and cAMP- dependent Protein Kinase-like Activities in Trypanosoma evansi
... contains protein kinases capable of phosphorylating endogenous substrates with appar- ent molecular masses in the range between 20 and 205 ...tubulin kinase was a casein kinase 2 (CK2)-like ...casein ...
10
Schistosoma mansoni Polo-like kinases and their function in control of mitosis and parasite reproduction
... It is interesting to note that S. mansoni expresses only two members of the Plk family, SmPlk1 and Sm- Sak, and no Plk2 and Plk3 homologs, two isoforms yet present in the helminth C. elegans. Experiments with ...
9
Nickel-resistance determinants in Acidiphilium sp. PM identified by genome-wide functional screening.
... carrier protein transacylase; pSRNi6_orf3: polysaccharide export protein; pSRNi6_orf4: non-specific protein-tyrosine kinase; pSRNi16_orf1: dihydroxy-acid dehydratase; pSRNi16_orf2: hypo- ...
11
Rev. Bras. Hematol. Hemoter. vol.37 número5
... Other important components of this negative regula- tory complex include multifunctional proteins with ubiquitin ligase activity, such as CBL. CBL is usually involved in the negative feedback of tyrosine kinase ...
6
Protein kinase A binds and activates heat shock factor 1.
... might override the inhibitory influence of S303 phosphorylation and stimulate HSF1 trans activation. However, the current studies suggest a role for PKAca and S320 in permitting HSF1 to accumulate in the nucleus and in ...
13