Receptor protein - tyrosine kinase
Coarse-grained molecular simulation of epidermal growth factor receptor protein tyrosine kinase multi-site self-phosphorylation.
... the kinase active site were also considered to make native contacts (again a ...P-site tyrosine in the docked structure formed nine total native contacts with active site residues (in addition to three ...
20
Oral and craniofacial manifestations and two novel missense mutations of the NTRK1 gene identified in the patient with congenital insensitivity to pain with anhidrosis.
... NTRK1 protein (TRKA) is a tyrosine kinase receptor comprising an extracellular domain involved in NGF binding, a single transmembrane region, a juxtamembrane domain, a tyrosine ...
10
Protein tyrosine kinases in Schistosoma mansoni
... type protein kinase C identified in ...(casein kinase 2) phosphorylation, being related to the biogenesis of the ribosome 60S subunit as well as to the cell cycle with higher expression levels in ...
8
Effects of lipopolysaccharide on low- and high-density cultured rabbit vascular smooth muscle cells: differential modulation of nitric oxide release, ERK1ERK2 MAP kinase activity, protein tyrosine phosphatase activity, and DNA synthesis
... of receptor-like PTP with increas- ing cell density has been described in fibro- blasts of different origins ...reduced tyrosine phosphoryla- tion of the growth factor ...
10
Caracterização do Grb10 em complexos cumulus-oócito oriundos de folículos bovino de diferentes tamanhos Paulo Roberto Antunes da RosaI Rodrigo Camponogara BohrerI Charles Alencar Ludke
... Grb10 protein is known to have different isoforms that are responsible for binding several trans-membrane tyrosine-kinase receptors, including the insulin receptor (IR), the insulin-like ...
7
EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE).
... EphA4 has been shown to regulate recovery from spinal cord injury (Goldshmit, Fabes, etc refs) and may play a role in ischemia [23]. We have shown here that EphA4 knockout mice have markedly attenuated MOG ...
11
Insulin receptor has tyrosine kinase activity toward Shc in rat liver
... insulin receptor substrate-1 (IRS-1) and Shc (src homology 2/ α collagen related), a ubiquitously ex- pressed intracellular signaling protein, share a related amino-terminal region called Shc and the IRS-1 ...
6
Protein tyrosine kinase inhibitors modify kainic acid-induced epileptiform activity and mossy fiber sprouting but do not protect against limbic cell death
... Both protein tyrosine kinase inhibitors used in the pres- ent study were able to modify kainate-induced epileptiform ...for tyrosine substrates, including strong inhibitory activity on the ...
8
Rev. Bras. Hematol. Hemoter. vol.33 número6
... factor receptor-bound protein-2 (Grb2), growth factor receptor-binding protein complex (Gab2), SRC kinase family and focal adhesion kinases ...
6
Signal transduction induced in Trypanosoma cruzi metacyclic trypomastigotes during the invasion of mammalian cells
... cell receptor triggers a signaling cascade leading to sequential activation of protein tyrosine kinase and phospholipase C, with consequent generation of IP 3 ...
10
The Kinome of Pacific Oyster Crassostrea gigas, Its Expression during Development and in Response to Environmental Factors.
... G protein coupled ...one protein kinase AKT (Protein kinase B) (while there are three in human and two in sea urchin) and one p70S6K (2 in human; 1 in sea ...lipid tyrosine ...
24
Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies.
... Selection of chimeric rabbit/human Fab by phage display The three extracellular domains of human ROR1 were expressed alone (hROR1ECD) or as fusion protein with the Fc domain of human IgG1 (Fc-hROR1) (Fig. 1). ...
15
A novel classification of lung cancer into molecular subtypes.
... MET inhibitors. While secondary mutations in EGFR are responsible for the majority of cases of acquired EGFR TKI resistance, activation of other pathways can also lead to resistance. For example, c-MET amplification has ...
11
Rev. Bras. Hematol. Hemoter. vol.39 número3
... with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing ...
2
Estrogenic Regulation of the SCF/c-KIT System in Prostate Cells: a Relationship with Prostate Cancer?
... The SCF protein is constituted by three distinct regions (Fig. I-4): an intracellular domain (Langley et al., 1994;Zhang et al., 2000), an hydrophobic transmembrane domain, and an extracellular domain responsible ...
110
Rev. Bras. Hematol. Hemoter. vol.31 suppl.2
... powerful tyrosine kinase inhibitors (TKIs) have been developed and ...Sequential kinase inhibitor therapy is used to overcome resistance however, a future strategy might be a combination therapy with ...
4
MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells.
... factor receptor (EGFR), member of the human epidermal growth factor receptor (HER) family controls key cellular programs, including survival, proliferation, differ- entiation and migration during ...
22
Clinics vol.68 número10
... adhesion kinase (FAK), a tyrosine kinase involved in cell proliferation, adhesion and migration ...this protein in erythroid and myeloid progenitors resulted in a reduced cell growth and ...
5
Einstein (São Paulo) vol.15 número1
... Recessive summary effect of the protein tyrosine phosphatase non-receptor 22 (C1858T) polymorphism with endometriosis without the study whose controls deviated from the Hardy-Weinberg [r] ...
7
Revisiting the roles of VHRDUSP3 phosphatase in human diseases
... Protein tyrosine phosphatases have long been considered key regulators of biological processes and are there- fore implicated in the origins of various human ...a protein tyrosine phosphatase ...
7