20S Proteasome
The 20S proteasome splicing activity discovered by SpliceMet.
... subunit 20S proteasome is the central catalytic unit of the ubiquitin proteasome system (UPS) and catalytic core of the 26S proteasome that is built by the association of the two 19S regulator ...
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Plastidial starch phosphorylase in sweet potato roots is proteolytically modified by protein-protein interaction with the 20S proteasome.
... suggesting that heat treatment can trigger the proteolytic modification at the L78 insertion of Pho1 in sweet potato roots. Interestingly, a different form of the 20S proteasome with Figure 1. A high ...
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Circulating 20S proteasome is independently associated with abdominal muscle mass in hemodialysis patients.
... circulating 20S proteasomes is not known in our cohort, but several possibili- ties are ...circulating 20S proteasomes may be released passively from the mus- cle as a result of cellular damage ...the ...
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Transferrin surface-modified PLGA nanoparticles-mediated delivery of a proteasome inhibitor to human pancreatic cancer cells
... Poly (D,L-lactide- co -glycolide) (PLGA, Resomer RG 503 H, lactide:glycolide 50:50, Mw 24,000–38,000), Pluronic F127 (PF127), ethyl acetate, N -Succinyl- Leu-Leu-Val-Tyr-7-Amido- 4-Methylcoumarin (Suc-LLVY-AMC), human ...
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The proteasome-ubiquitin pathway in the Schistosoma mansoni egg has development- and morphology-specific characteristics
... the 20S protea- some through the aperture in the centre of either outer ␣-subunit ring, the process being controlled by a multi-subunit component called the 19S regulatory complex (also known as PA700), which caps ...
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Genome-wide identification, characterization and expression profiling of the ubiquitin-proteasome genes in Biomphalaria glabrata
... the proteasome is composed of α and β ...the 20S proteasome between α and β subunits were identified in ...conserved proteasome domain in their N- terminal portions ...
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Synergy between proteasome inhibitors and imatinib mesylate in chronic myeloid leukemia.
... the 20S proteasome for degradation ...function, proteasome has been shown to be an appropriate therapeutic target for ...the proteasome inhibitor I (PSI, Z-Ile-Glu(OtBu)-Ala-Leuc- inal)[18] ...
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Effect of ionizing radiation exposure on Trypanosoma cruzi ubiquitin-proteasome system.
... cruzi 20S proteasome possess trypsin-like, chymotrypsin-like and caspase- like activities [9] and may be free or linked to regulatory particles (PA700, PA26, and PA200) [10] ...of 20S bind to its ...
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Integrated analysis of microarray data of atherosclerotic plaques: modulation of the ubiquitin-proteasome system.
... ubiquitin proteasome system in atherosclerotic ...The proteasome activity (chymotrypsin-like, trypsin-like and caspase-like activity) in Ctrl, EA and AA was ...of proteasome in EA and AA groups were ...
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Bowman-Birk inhibitors, proteasome peptidase activities and colorectal pre neoplasias induced by 1,2-dimethylhydrazine in Swiss mice
... 2002). Experiments aimed at elucidating the mechanism of action of BBIs, as cancer preventive agents, showed an increased expres- sion of proteolytic enzymes exhibiting trypsin- and chymotryp- sin-like activities. These ...
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The ubiquitin/proteasome pathway from Lemna minor subjected to heat shock
... a proteasome subunit was induced by heat shock in ...both 20S and 26S forms coexisted in eukaryotic cells (Yang et ...the 20S proteasome may be involved in the degradation of oxidatively ...
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PACemakers of proteasome core particle assembly
... of proteasome assembly chaperones from eubacteria and archaeons indicates that evolution of these fac- tors coincided with the increased subunit complexity of 20S pro- teasomes acquired by ...mature ...
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Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.
... the 20S proteasome proteolytic activities. Purified 20S proteasomes were treated for 30 min with or without RAMB compounds or Bortezomib, here used as positive control, at the indicated ...
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Proteasome-proteins: are these putative targets for basal-like breast cancer therapy with AAV-vectors?
... 1.2.2. Proteasome as targets for BLBC therapy with AAV vectors The 26S proteasome is a large multicatalytic proteinase complex, which is responsible for maintaining homeostasis and plays a vital role in ...
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Systemic analysis of heat shock response induced by heat shock and a proteasome inhibitor MG132.
... Heat shock response (HSR) is an evolutionarily conserved defense mechanism against sudden stresses such as elevated temperatures or environmental changes. A major component of HSR is the induction of heat shock proteins ...
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Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.
... The Rpn13 protein, previously termed adhesion-regulating protein 1 or GP110, has been identified as a tumor-associated gene product [1,2,3,4,5,6], and more recently as an amplification target in ovarian cancer [7]. ...
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Chemical patterns of proteasome inhibitors: lessons learned from two decades of drug design
... assays, therefore excluding any sort of indirect measurements originated from phenotypic assays. The corresponding SMILES retrieved from ChEMBL were converted to 3D structures with Molecular Operating Environment (MOE) ...
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Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.
... ubiquitin proteasome system (UPS) arm of ER stress via its role in establishment and maintenance of pericentrosomal localization of aggresomes (complexes of misfolded proteins, chaperones and proteasomes) ...
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Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.
... although proteasome inhibitor treatment has been associated with ER stress and the UPR, the specific contribution of proteasome inhibitors to ER stress-mediated cell death may be obscured by the ...
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Genome-wide identification, characterisation and expression profiling of the ubiquitin-proteasome genes in Biomphalaria glabrata
... Nineteen genes from the RPN and RPT groups were identified in our analysis (Table I), encompassing se- quences of major importance such as RPN-11, RPN-15 and RPN-3, involved with target substrate recognition and removal ...
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