Toll Like Receptor 1
Toll-like receptor -1, -2, and -6 polymorphisms and pulmonary tuberculosis susceptibility: a systematic review and meta-analysis.
... Tuberculosis (TB) is a contagious and potentially fatal disease caused by various strains of mycobacteria, usually Mycobacte- rium tuberculosis (Mtb) in humans. It can infect almost any part of the body, but manifests ...
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Small Heterodimer Partner and Innate Immune Regulation
... Fig. 1. Roles of the orphan nuclear receptor small heterodimer partner (SHP) in the toll-like receptor 4 (TLR4)-mediated inflammatory response and NLRP3 (NACHT, LRR and PYD ...
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Association between Toll-like receptor 4 Asp299Gly polymorphism and coronary heart disease susceptibility
... Epidemiological studies have strongly supported a pivotal role for inflammatory, innate immune, and adaptive immune mechanisms in the pathogenesis of atherosclero- sis (1,2). Although the importance of ...
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Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection.
... By day 10 post-infection, 70% of C3H/HeJ mice had died, while all control mice recovered from infection (Figure 3A). As in the previous experiment, loss of body temperature was measured as a sign of morbidity. C3H/HeJ ...
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Characterization of the Toll-like receptor expression profile in human multiple myeloma cells.
... In FACS experiments, indirect (intra)cellular staining was performed using TLR-specific antibodies. Briefly, 10 5 cells from each cell line or BMNCs were harvested and washed in FACS buffer, PBS+0.5% BSA+0.01% sodium ...
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Toll-Like Receptor 4 Is Essential in the Development of Abdominal Aortic Aneurysm.
... In present study, we demonstrate a potential mechanism that TLR4 is an integral signaling molecule in regulating not only proteinase expression but also inflammation in VSMCs during aneurysm formation. TLR4 signaling ...
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Predicting novel features of toll-like receptor 3 signaling in macrophages.
... To investigate and locate the likely position of the necessary missing intermediary steps in the TLR3 pathway predicted by the Figure 2. Analysis of TLR3 pathway in macrophages. A) Schematic representation of the ...
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Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants.
... TLRs 1 – 9 in whole blood cultures derived from Gambian infants during the first year of ...by 1 month of age the pro- inflammatory responses to most TLR agonists were increased, with predominance of ...
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Identification of Key Genes and Pathways in Rheumatoid Arthritis Gene Expression Profile by Bioinformatics
... cytokine-cytokine receptor interac- tion, toll-like receptor signaling pathway, TNF signa ling pathway, rheumatoid arthritis, and so ...including toll- -like receptor 7 ...
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Avaliação da resposta imune após estimulação de monócitos via Toll-Like Receptor...
... Group 1, which displayed a reduced frequency of CD80 + cells in both DC subsets compared with Group 3 and ...Group 1 was compared with adults, while Group 1 had significantly less of these cells ...
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Comprehensive logic based analyses of Toll-like receptor 4 signal transduction pathway.
... = 1) and off state ( = 0) of a species, as once ERK-1/2 attains an on state it will transmit the information to IL-10 through intermediates irrespec- tive of wiring of signaling intermediates upstream to ...
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Controlling the outcome of the Toll-like receptor signaling pathways.
... Searching essential reactions or genes (i.e. MCS or EGS) for an objective has two applications. Firstly, this information can be used to disable the objective. Secondly, it can identify key elements to maintain in order ...
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Expressão de receptores Toll-like - 2 e Toll-like - 4 em membranas corioamnióticas de gestações complicadas por corioamnionite
... receptores Toll-like (TLR) 14 ...receptores Toll-like em tecidos humanos, os quais são denominados TLR 1-10 15 ...domínio receptor Toll/IL-1, o qual compartilha uma ...
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Bioinformatics analysis of the structural and evolutionary characteristics for toll-like receptor 15
... family 1 on the phylogenetic tree. Unlike the TLRs in family 1 with the broken asparagine ladders in the middle, TLR15 ectodomain had an intact asparagine ladder that is critical to maintain the overall ...
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Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation.
... immunized 1-month old TLR4 WT or TLR4 P712H mice with ...or 1 mg of ...of 1:100) upon immunization with the 1 mg dose of LPS (Figure ...the 1 mg dose of LPS (data not ...
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Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3.
... Figure 1. Quiescent and activated HSCs express Toll like ...day 1) or activated myofibroblasts (culture day 10) were separated by SDS-PAGE and immunoblotted for TLR3 and ...(C) Toll- ...
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Toll-like receptor agonist augments virus-like particle-mediated protection from Ebola virus with transient immune activation.
... with 1 or 10 m g of polyICLC, similar to observations after murine IP treatment [21], and we further document up-regulation of the chemokines MCP1, MIP1a, KC, and MIP1b after adjuvant ...
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Structural study of binding of flagellin by Toll-like receptor 5
... Table 1 lists hydropathically complementary fragments be- longing to TLR-5 and the flagellins of three bacterial ...Table 1, many instances of complemen- tary hydropathy between TLR-5 and the flagellins ...
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The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes.
... in 1 to 2% of the samples (N = 93 genomic DNAs tested for TLR1) and each of them define a new allele (see Table S1) which was observed at a low frequency ...
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Phylogeny of Toll-like receptor signaling: adapting the innate response.
... The need to conserve the capability to recognize specific pathogen signature while at the same time allowing for the development of new platforms on which to build more complex signaling networks drives the evolution of ...
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