β-catenin
Btk29A-mediated tyrosine phosphorylation of armadillo/β-catenin promotes ring canal growth in Drosophila oogenesis.
... dramatically in Btk29A ficP -mutant egg chambers (Figs. 3G and 3H). Unlike in the previous re- port on Btk29A k05610 [15], residual anti-phosphotyrosine staining was observed, possibly due to type 1 activities remaining ...
13
Zinc Protoporphyrin Suppresses β-Catenin Protein Expression in Human Cancer Cells: The Potential Involvement of Lysosome-Mediated Degradation.
... suppression β-catenin protein expression is a result of lysosomal enzyme digestion of cellular ...of β-catenin expres- ...of β-catenin protein expression by ZnPP further ...
12
Selective dicer suppression in the kidney alters GSK3β/β-catenin pathways promoting a glomerulocystic disease.
... Dicer is an important protein for miRNA maturation and function. miRNAs are involved in post-transcriptional regulation of several proteins, and their role is crucial for many organs. Deletion of Dicer is the most common ...
17
C/EBPα Short-Activating RNA Suppresses Metastasis of Hepatocellular Carcinoma through Inhibiting EGFR/β-Catenin Signaling Mediated EMT.
... HCC is the most common primary malignancy of the liver [19]. Tumor metastasis is the cause of poor prognosis after hepatectomy, and thus high mortality of HCC [20].Several molecular pathways and regulatory genes have ...
14
Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin β1/GSK3β/β-Catenin Signaling Pathway.
... supernatant of HCC cells with integrin β1 knock-down cultured on 16kPa stiffness substrate had also decreased (Fig 1D). Subsequently, we added recombinant human OPN into culture medium of HCC cells grown on different ...
13
UBE3C promotes growth and metastasis of renal cell carcinoma via activating Wnt/β-catenin pathway.
... The Wnt/β-catenin signaling pathway has been reported to be associated with various kinds of human carcinomas including ccRCC [4–6]. β-catenin is considered as a positive regulator of this ...
13
Upregulation of β-catenin and cadherin expression in hearts of mice in acute and chronic phase of experimental trypanosome cruzi infection
... and β-catenin expression in acute and chronic ...and β-catenin overexpression was higher in acute than chronic stage when compared to respective ...
9
Crosstalk between Wnt/β-catenin and estrogen receptor signaling synergistically promotes osteogenic differentiation of mesenchymal progenitor cells.
... Osteogenic differentiation from mesenchymal progenitor cells (MPCs) are initiated and regulated by a cascade of signaling events. Either Wnt/β-catenin or estrogen signaling pathway has been shown to play an ...
13
cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/β-catenin pathway.
... Noncoding RNAs (ncRNAs) are the dominant product of eukaryotic transcription. These products range from short microRNAs (miRNAs) to long intergenic noncoding RNAs (lincR- NAs). Circular RNAs composed of exonic sequences ...
10
Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.
... activated β-catenin promotes liver tumori- genesis, we generated zebrafish that express a mutated form of Xenopus laevis ctnnb1/β-catenin (pt-β-cat)[16] under the control of ...
32
S100 calcium-binding protein A6 promotes epithelial-mesenchymal transition through β-catenin in pancreatic cancer cell line.
... and β-catenin was knocked down using a specific short hairpin RNA ...Furthermore, β-catenin shRNA inhibited the migration and invasion of PDAC ...of β-catenin in ...of ...
14
Retraction: The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling.
... Citation: Gherzi R, Trabucchi M, Ponassi M, Ruggiero T, Corte G, Moroni C, et al. (2015) Retraction: The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling. ...
1
A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.
... Our data shows that this agent can suppress the effects of high levels of b-catenin due to activation by a Wnt ligand, a growth factor known to activate b-catenin mediated transcription, and an oncogenic ...
8
β-Catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors.
... Figure 1. Constitutive TCF/LEF activity in hematopoietic tumor cells in the absence of b-catenin stabilization. (A) The indicated hematopoietic tumor cells were transduced with wild-type (Top) or mutant (Fop) ...
13
Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/β-catenin antagonist Chibby.
... walls, coincident with a decrease in the lung parenchymal tissue in Cby 2/2 mice. Our data suggest that the alveolar phenotype of Cby 2/2 mice results, at least in part, from reduced proliferation and altered ...
13
Modulation of β-catenin signaling by glucagon receptor activation.
... Wnt/b- catenin signaling may help pancreatic cells survive and ...b- catenin signaling may play a similar role in regulating liver cell proliferation and ...Wnt/b- catenin signaling often occurs in a ...
11
Multi-level interactions between the nuclear receptor TRα1 and the WNT effectors β-catenin/Tcf4 in the intestinal epithelium.
... In conclusion, we have shown that in the context of intestinal lesions, TRa1 reshapes its function and induces specific genomic and non-genomic events. TRa1 transcriptional activity was negatively modulated by increased ...
13
miR-346 regulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the Wnt/β-catenin pathway.
... Osteogenic differentiation of human mesenchymal stem cells (hMSCs) is regulated by multiple transcription factors and signaling molecules. However, the molecular mechanisms underlying this process remain to be fully ...
8
PDGF upregulates Mcl-1 through activation of β-catenin and HIF-1α-dependent signaling in human prostate cancer cells.
... nuclear CREB expression upon PDGF treatment (data not shown), suggesting that CREB may not be involved in the b- catenin-dependent activation of Mcl-1 transcription. Intriguingly, the transcription factor HIF-1a ...
12
Activation of β-catenin by oncogenic PIK3CA and EGFR promotes resistance to glucose deprivation by inducing a strong antioxidant response.
... b- catenin in wild type cells under GD was mainly dependent on GSK3b kinase activity since exposure to the GSK3b inhibitor, lithium chloride, eliminated the phosphorylation of these residues of b-catenin ...
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