Vaccine Development
Characterization of the Burkholderia mallei tonB Mutant and Its Potential as a Backbone Strain for Vaccine Development.
... for vaccine development against these pathogens includes identification of broadly protective antigens and a better understanding of the correlates of protection from both acute and chronic ...legitimate ...
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Implications of differential age distribution of disease-associated meningococcal lineages for vaccine development
... There has been a decline in meningococcal disease incidence in Europe since 1999, decreasing from 1.9 cases per 100,000 individuals in 1999 to 0.73 cases per 100,000 individuals in 2010 (21). This decline is due in part ...
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Immunologically reactive M. leprae antigens with relevance to diagnosis and vaccine development
... As with other diseases, rapid and objective diagnosis of leprosy could be achieved by the recognition of dis- ease-specific immune responses [8]. Due to the dichoto- mous nature of immune responses of leprosy patients, ...
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REPOSITORIO INSTITUCIONAL DA UFOP: Immunoinformatics features linked to leishmania vaccine development : data integration of experimental and in silico studies.
... effective vaccine should have epitopes capable of eliciting a strong T cell response and B cells ...for vaccine development ...for vaccine development against ...
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The end of the line for hookworm? An update on vaccine development.
... the vaccine at low cost and high yield, its distribution in the tropics, and the possible requirement to de- worm individuals prior to ...Hookworm Vaccine Initiative is progressing on many of these fronts ...
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Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development
... The antigenic potential of seven immunogenic peptides of the dengue virus was evaluated in the sera of patients with dengue confirmed by IgM/IgG serology. Antibodies IgM and IgG against dengue virus peptides were analyzed ...
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The steroid catabolic pathway of the intracellular pathogen Rhodococcus equi is important for pathogenesis and a target for vaccine development.
... Rhodococcus equi causes fatal pyogranulomatous pneumonia in foals and immunocompromised animals and humans. Despite its importance, there is currently no effective vaccine against the disease. The actinobacteria ...
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CD8(+) T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?
... MHC-restricted CD 8 + T cells are important during infection with the intracellular protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. Experimental studies performed in the past 25 years have ...
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Different Models of DNA Immunization as Strategy for Vaccine Development Against African Trypanosomiasis
... African Trypanosomiasis, also known as sleeping sickness, caused by the protozoan Trypanosoma brucei, is a neglected tropical disease. This disease can be successfully controlled, as has been proven in the past; ...
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Schistosoma mansoni major egg antigen Smp40: molecular modeling and potential immunoreactivity for anti-pathology vaccine development
... prevent or ameliorate clinical signs of schistosomiasis. S. mansoni major egg antigen Smp40 was expressed and completely purified. It was found that the expressed Smp40 reacts specifically with anti-Smp40 monoclonal ...
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Meningococcal factor H binding proteins in epidemic strains from Africa: implications for vaccine development.
... conjugate vaccine was under development for Africa, we included a dispropor- tionate number of serogroup W-135 and X isolates to provide data on the vaccine-potential of fHbp to extend coverage to ...
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Schistosomiasis Vaccine Development: Progress and Prospects
... The results described above underline the need for further exploration of antigen formulation with reference to influence and stability of adjuvants. This can be as important and influential in regard to outcome as the ...
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The Yellow Fever 17D Vaccine Virus as a Vector for the Expression of Foreign Proteins: Development of New Live Flavivirus Vaccines
... efficacious vaccine against YF but no other live flavivirus vaccines have been ...flavivirus vaccine develop- ...with vaccine production in cell culture should improve the reliability and lower the ...
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PARACOCCIDIOIDOMYCOSIS: CHALLENGES IN THE DEVELOPMENT OF A VACCINE AGAINST AN ENDEMIC MYCOSIS IN THE AMERICAS
... lutzii 29 , which is now known to be endemic in the North and Central- West regions of Brazil (States of Rondonia, Mato Grosso and Goias) and geographically partially overlaps with group S1. Despite the genetic ...
4
Is an HIV vaccine possible?
... a vaccine for HIV has been arduous and will continue to be difficult over the ensuing twenty ...a vaccine for HIV based on neutralizing ...HIV vaccine field has turned its attention to inducing T ...
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Characterisation of Plasmodium falciparum antigens for the development of serological assay or vaccine candidates for malaria
... In the context of human malaria, the mechanisms of immunity and protection during infections caused by Plasmodium sp. represent a major challenge and priority for research. Studies of humoral and cellular immunity ...
177
Ecuador approves vaccine law
... that vaccine and im- munization are key to the control, elimination and eradica- tion of vaccine-preventable diseases, this recognition has not been translated into concrete actions to promote and support ...
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New children's vaccine initiative launched
... Hiroshi Nakajima, Director-General of WHO, “Achieving the goals of the Children’s Vaccine Initiative will not only bring enormous specific benefits in improving vac[r] ...
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