Wnt/β- catenin Signaling Pathway
UBE3C promotes growth and metastasis of renal cell carcinoma via activating Wnt/β-catenin pathway.
... The Wnt/β-catenin signaling pathway has been reported to be associated with various kinds of human carcinomas including ccRCC ...[4–6]. β-catenin is considered as a ...
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cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/β-catenin pathway.
... the Wnt/β-catenin signaling pathway in CRC cells, we used a β-catenin/TCF-responsive lucif- erase reporter ...The β-catenin and Wnt3a levels were analysised ...
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Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin β1/GSK3β/β-Catenin Signaling Pathway.
... The Wnt/β-catenin pathway has been well docu- mented to involve in OPN regulation ...a Wnt-independent β-catenin pathway to modulate the OPN expression in HCC ...
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Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8.
... canonical Wnt/b- catenin signaling ...b- catenin signaling via frizzled receptors may result in saturation of the signal transduction capacity of pathway components down- stream ...
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Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway.
... of Wnt/b-catenin signaling represents a great opportunity to determine if FDA approved drugs might have potential anticancer efficacy ...potent Wnt/b-catenin signaling inhibitor ...
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High glucose induces podocyte injury via enhanced (pro)renin receptor-Wnt-β-catenin-snail signaling pathway.
... The Wnt gene encodes a large family of secreted proteins that have been identified from Hydra to Human ...Wntb-catenin signaling pathway, the non-canonical Wnt-Ca2+ pathway, and ...
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TGF-β-activated kinase 1 (TAK1) signaling regulates TGF-β-induced WNT-5A expression in airway smooth muscle cells via Sp1 and β-catenin.
... TAK1 signaling- p38 and JNK- redundantly mediate b-catenin regulation in response to ...AKT signaling [43] indicating the possible activation of PI3K/ AKT by TAK1 in response to ...AKT pathway ...
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Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway.
... To assay the b-catenin protein, cytoplasmic and nuclear proteins from cultured cells were prepared using NE-PER nuclear and cytoplasmic extraction reagents (Pierce Chemical Company, USA), respectively. b-Actin and ...
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Tcf3 represses Wnt-β-catenin signaling and maintains neural stem cell population during neocortical development.
... canonical Wnt pathway in early patterning of the cortex [48] and in proliferation/self-renewal of NPCs/radial glia have been well-established ...this signaling pathway promotes or inhibits ...
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miR-346 regulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the Wnt/β-catenin pathway.
... the Wnt/b-catenin pathway (Figure ...the Wnt signaling reporter TOPFlash or the negative control ...that Wnt/b-catenin signaling is altered by ...b- catenin ...
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Crosstalk between Wnt/β-catenin and estrogen receptor signaling synergistically promotes osteogenic differentiation of mesenchymal progenitor cells.
... Wnt signaling plays a critical role in embryonic development, postnatal development, and adult tissue homeostasis ...canonical Wnt signaling is the stabilization of β-catenin in ...
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Maternal Wnt/β-catenin signaling coactivates transcription through NF-κB binding sites during Xenopus axis formation.
... To provide evidence for an in vivo interaction, we performed co-immunoprecipitation experiments with endogenous RelA/p65 and b-Catenin proteins from REH cells (Figure 6D). This is a well- characterized B-cell ...
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Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells.
... key Wnt component that phosphorylates b-catenin and promotes its subsequent degradation via proteasome ...between Wnt/b-catenin and COX2 expression in different cancer cell models is further ...
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Divergent Androgen Receptor and Beta-Catenin Signaling in Prostate Cancer Cells.
... the Wnt-pathway in prostate cancer with disease ...the Wnt-pathway is one of the most significantly mutated pathways in CRPC ...the Wnt/β-cate- nin pathway ...in ...
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The effect of Calendula officinalis on oxidative stress and bone loss in experimental periodontitis
... another signaling pathway has stood out as a regulator of bone homeostasis, known as the canonical WNT pathway (Kobayashi et ...tissue, WNT proteins, mainly WNT10b, interacts with its ...
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Biphasic role of chondroitin sulfate in cardiac differentiation of embryonic stem cells through inhibition of Wnt/β-catenin signaling.
... on Wnt/beta-catenin ...the Wnt/beta-catenin pathway in fibroblasts [8,47] and breast cancer cells (Willis and Klu¨ppel, unpublished ...of Wnt/beta-catenin signaling ...
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Modulation of β-catenin signaling by glucagon receptor activation.
... b-catenin signaling from GCGR? Wnt/b-catenin signaling helps to promote stem cell renewal and in many cases favors proliferation over ...that Wnt/b- catenin ...
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Discovery of novel small molecule activators of β-catenin signaling.
... mouse Wnt-3a (rmWnt-3a) and 30 mM lithium chloride (LiCl) (Figure 1C). Wnt-3a is a naturally occurring Wnt ligand that activates Wnt/b-catenin signaling in several contexts ...of ...
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Selective dicer suppression in the kidney alters GSK3β/β-catenin pathways promoting a glomerulocystic disease.
... Dicer is an important protein for miRNA maturation and function. miRNAs are involved in post-transcriptional regulation of several proteins, and their role is crucial for many organs. Deletion of Dicer is the most common ...
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WNT signaling pathway gene polymorphisms and risk of hepatic fibrosis and inflammation in HCV-infected patients.
... canonical Wnt-beta catenin signaling pathway and the androgen receptor or androgens, including androgen activation of beta-catenin signaling in bladder cancer cells [31] and ...
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