[PDF] Top 20 Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional study

... a case-control design on two datasets, from Spain and ...to the Emergency Department of University Hospitals throughout Spain, recruited within the first 3 h after symptom ... See full document

... linkage analysis [18] in ethnically homogeneous pedi- grees has provided strong evidence for schizophrenia risk locus on chromosome ...which the nearest schizophrenia candidate gene is ...SNPs ... See full document

... a meta-analysis combining published studies and our current case-control study for further evaluation of the associations between the 3 SNPs and ... See full document

... this study, we investigated the association between rs13040307, rs752118 and rs3765459 polymorphisms and risk of IS, but found no significant ...association. ... See full document

... subgroup analysis by ethnicity, the COX-2 ...a risk factor for CRC in Asian populations, but not in ...Caucasians. The inconsistent data among the different ethnicities ... See full document

... effect of slow ethanol oxidation might be counterbalanced by a higher tolerance to ethanol and thus a higher probability for hazardous alcohol ...pooled risk estimates for ADH1C*2/2, ... See full document

... The association between the T1858 allele at rs2476601 in the PTPN22 gene and RA has been documented in several cohorts, from the USA as well from Europe [38,39], ... See full document

... multifactorial and polygenic disease with major clinical manifestations and multiple aetiologies, and a significant cause of disability and death in developed countries ... See full document

... SNPs in the 5⬘ end of KALRN, a large portion of its natural genetic variation was not assessed because it is a very large gene with a high degree of genetic ...SNPs ... See full document

... interpret the present meta-analysis results, it is necessary to clarify the difference between this meta- analysis and the previous ...a meta-analysis ... See full document

... variants of the gene encoding 5-lipoxygenase-activating protein (ALOX5AP) leading to amino acid substitutions have been ...variants in the ALOX5AP promoter region have received ... See full document

... monocytes and fibroblasts. It is an important mediator for the inflammatory responses and play key roles in the triggering of immune functions, effecting nearly every cell ... See full document

... among the five cohort studies, so a fixed-effect model was chosen, and we found that total fish consumption did not significantly affect the risk of ovarian cancer among cohort ... See full document

... this meta-analysis, no association of the IL-10 21082A/G polymorphism with IS risk was found under all comparisons, and in subgroup analysis by ... See full document

... Environment and Health Initiative (GEI) Grant U01 HG004436, as part of the GENEVA consortium under GEI, with additional support provided by the Mid-Atlantic Nutrition and Obesity ... See full document

... interfered with our meta-analysis. First, the number of recruited studies and sample size in each study is relatively limited, which might make it easier for ... See full document

... participating in oxidative stress, initiating endothelial and lipid peroxidation and pro- moting nitric oxide synthase, thereby reducing the endothelium-derived relaxation factor, causing dys- ... See full document

... investigated the effect of doctors’ experience adjusted for patient characteristics with binary logistic regression to ascertain which patients were most likely to be optimistically ...sensitivity ... See full document

... associated with the specific pathomechanism of ische- mic stroke [7, ...8]. The insula is supplied directly by the proximal portions of the two main branches ... See full document

... private and public urologists in Queensland, Australia via three prostate cancer studies or resources: the Retrospective Queensland Study (N = 154; [26]), the Prostate Cancer Supportive ... See full document