[PDF] Top 20 Characterization of the mechanisms of protein translocation across the mammalian peroxisomal membrane
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Characterization of the mechanisms of protein translocation across the mammalian peroxisomal membrane
... isoform of human PEX5 (50, 51), hereafter referred to as PEX5 for simplic- ity, a protein comprising the first 324 amino acid residues of PEX5 ( ⌬C1PEX5), a protein containing amino ... See full document
101
Ubiquination and deubiquitination in the mammalian pex5-mediated peroxisomal protein import pathway.
... PEX5, the peroxisomal cycling receptor, plays a key role in the import of matrix ...in the cytosol and are then targeted to the organelle ...strong protein-protein ... See full document
91
Revisiting the intraperoxisomal pathway of mammalian PEX7
... to the peroxisome by a mutant PEX5 species that cannot be mono-ubiquitinated because it lacks the conserved cysteine 11 ...C1PEX5L(C11A)), the subsequent export of PEX7 back into the ... See full document
12
Pex5p, the peroxisomal cycling receptor, is a monomeric non-globular protein
... targeting of newly synthesized peroxiso- mal matrix proteins to the organelle requires Pex5p, the peroxisomal cycling ...multidomain protein involved in a complex network of ... See full document
8
Ubiquitin in the peroxisomal protein import pathway
... in the insertion of PEX5 into the DTM with PEX5 adopting a transmembrane topology ...[33,34]. The presently available data suggest that cargo translocation across the ... See full document
17
The pex5-mediated import pathway: characterization of the translocation step
... to the peroxisomal membrane, where it interacts with the docking protein, PEX3 (Götte et al, 1998; Fang et al, 2004; Hoepfner et al, 2005; Muntau et al, 2003; Pinto et al, ...2006). ... See full document
140
Biogenesis of peroxisomal intrinsic membrane proteins: unveiling the role of pex19p.
... yeasts, mammalian Pex3p mistargets to mitochondria when overexpressed in both normal and PEX19-deficient cells [92, 95-97] and so far has not been found in the ER ...in mammalian peroxisome ... See full document
93
The first minutes in the life of a peroxisomal matrix protein
... at the DTM, do so bound to several PEX5 molecules ...one of these PEX5 molecules, the first to collide with the DTM, becomes inserted into the DTM thus pushing the oligomeric ... See full document
26
Mapping of the cargo protein membrane translocation step into the PEX5 cycling pathway.
... in the eukaryotic kingdom characterized by a single membrane and a dense protein matrix comprising a large set of enzymes ...in the metabolism of lipids, ethanol and glyoxylate, ... See full document
86
Protein translocation across the peroxisomal membrane.
... ing protein complexes from the peroxisomal membrane of different model ...organisms. The first peroxin-containing complex to be isolated was the Pex5p-Pex14p ... See full document
18
On the cephalothorax of the pink shrimp: II. Isolation and chemical nutritional characterization of the protein.
... A adequação do referido método ao material de estudo foi necessária, em virtude de o mesmo ser destinado a resí- duos não especificados de camarão, omi- tir cert[r] ... See full document
4
Structure-based druggability assessment of the mammalian structural proteome with inclusion of light protein flexibility.
... NY), the results of which are used to compute ...from the command line with options that return the 5 largest SiteMap sites, in order of the number of site points they ... See full document
13
Molecular mechanisms linking the phosphorylation of the protein Bax to its activation during apoptosis
... proteins of this family can regulate the permeability of the OMM, which is considered to be a major checkpoint of ...apoptosis. The molecular mechanism is still unclear, but it ... See full document
87
Characterization of the early proliferative response of the rodent bladder to subtotal cystectomy: a unique model of mammalian organ regeneration.
... capacity of the bladder has been recognized in rodents, canines and humans for de- ...with the limitations and complications associated with using intestinal bowel segments has led to pursuit ... See full document
11
The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes.
... analyses of the Nemp ...by the Maximum Likelihood (ML) method using Treefinder with the protein matrix LG after amino acid sequences of the DUF2215 domain in various or- ... See full document
21
Using green fluorescent protein to understand the mechanisms of G-protein-coupled receptor regulation
... quence of receptor ...overstimulation of GPCR signaling cascades which in the case of constitutively active mutant receptors leads to diseases such as retinal degeneration, pre- cocious ... See full document
8
Characterization of the cGMP-dependent protein kinase SmcGK1 of Schistosoma mansoni
... disease of worldwide signi- ficance for humans and animals and is caused by para- sitic helminths of the genus Schistosoma (Savioli et ...in the last decade to develop an effective vaccine ... See full document
12
Widespread protein aggregation across the mouse lifespan
... is the most aggressive form of skin cancer and one of the most challenging malignancies to treat with a steeply rising incidence and a poor prognosis in advanced ...treatment of ... See full document
76
Dynamic proteomics of human protein level and localization across the cell cycle.
... Regulation of proteins across the cell cycle is a basic process in cell ...lack of methods to accurately follow protein levels and localizations over ...percent of human genes ... See full document
11
The Dark Side of the Light: Mechanisms of Photocarcinogenesis
... combination of UV-induced superoxide and excess ni- tric oxide generates the powerful oxidant peroxynitrite, which degrades melanin to dioxetane-containing lipophilic fragments that can move to the ... See full document
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