[PDF] Top 20 Mutagenicity of hydroxyurea in lymphocytes from patients with sickle cell disease

... used in the treatment of myeloproliferative diseases and in patients with sickle cell disease ...use of this antineoplastic agent in patients ... See full document

... Introduction: Patients with sickle-cell disease (SCD) present chronic hemolysis with increased serum ...polymorphisms of the BLC11A gene modulate fetal hemoglobin (HbF), ... See full document

... performed in a state pediatric hospital located in the city of Teresina, Piauí, Brazil, this institution is reference in the treatment of children with ...receives ... See full document

... Sickle cell anemia is determined by the presence of S hemoglobin in homozygous, autosomal recessive and characterized by the presence of red cells with abnormal shape ... See full document

... Sickle cell disease is a genetic hemoglobinopathy characterized by the presence of an abnormal molecule of hemoglobin, called hemoglobin S (HbS) [1] When present in homozygous ... See full document

... incidence of hypertension in patients with SCD [17]. In fact the levels of blood pressure were similar between SCD patients and controls in our ...increase ... See full document

... treating patients with sickle cell anemia, this intervention may lead to immunological disturbs, such as alloimmunization by erythrocyte ...50% of patients with ... See full document

... safety of autologous bone- marrow mononuclear cells (BMMC) implantation in necrotic lesions of the femoral head in patients with sickle cell ...eight ... See full document

... cases of sickle cell anemia from a micro region in the state of Piauí, emphasizing the treatment adopted during the disease and the vaccination status of the ... See full document

... total of 23 (21 SS and 2 SC) sickle cell disease patients (10 males and 13 females) presenting VOC due to different inducing factors were studied, including 2 with pri- apism, 2 ... See full document

... 130 of the 1934 participants were 2- to 16-year-old children who had changed TCD (mean CBFV > 200 cm/s in one or both of the middle cerebral arteries or the distal segment of the internal ... See full document

... production of lactic acid is one of the most important phenotypical feature that should be analyzed when studying the cariogenicity of ...strains. In the present study, although the pH ... See full document

... paradox of a population affected by severe endotheliopathy and vasculopathy and accelerated organ damage, yet largely spared from systemic ...role of anemia, resulting in increased cardiac ... See full document

... seen in sickle cell disease ...role of hydroxycarbamide as a protective agent in sickle cell ...Setting Patients with SCD followed at a Hematology ... See full document

... production in patients with sickle-cell anemia ...inluence of hydroxyurea (HU) therapy on this marker in patients with ...samples from 53 ... See full document

... uses hydroxyurea (HU), which is used to maintain high foetal haemoglobin (HbF) levels and consequently reduce haemoglobin S (HbS) ...associated with the use of hydroxyurea may be attributed to ... See full document

... III.9c), in all 66 samples, using the methodology optimized by Thomas, et ...product of 169 bp (4 repetitions of 27 bp); allele 4b, originating a PCR product of 196 bp (5 repetitions of ... See full document

... [25]. Sickle cell anemia is a hemolytic red cell disorder and all patients with SCD have variable degrees of hemolysis and it is most severe in ...severity of ... See full document

... lack of correlation between HbF lev- els and G γ/ A γ ratio suggests that the return to the fetal γ chain synthesis does not imply an absolute increase of HbF ...range of factors, both genetic and ... See full document

... correlated with age and ...BMD in this study [5]. In another study on 17 SCA patients, osteopenia frequency was 47% and serum iron and ferritin levels were found higher in osteopenic ... See full document