[PDF] Top 20 The peroxisomal matrix protein import machinery - a PEX5 - centered perspective
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The peroxisomal matrix protein import machinery - a PEX5 - centered perspective
... to import already oligomerized proteins (reviewed in (126, ...supporting the import of oligomerized proteins are plentiful, this route may not be that ...many peroxisomal matrix ... See full document
115
The pex5-mediated import pathway: characterization of the translocation step
... organisms, import of all cargo proteins into the peroxisomal matrix relies on the peroxisomal shuttling receptor, PEX5 (Otera et al, 1998; Braverman et al, 1998; Galland ... See full document
140
The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo
... that the DTM can accommodate more molecules of PEX5(1- 197;C11A) than full-length PEX5 is particularly ...at the DTM available to bind a single full-length PEX5 molecule contains more ... See full document
40
Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery
... All matrix proteins are nuclear encoded and translated on free ribosomes and hence all these proteins must be posttransla- tionally imported into peroxisomes 1 ...to the organelle is ensured by ... See full document
13
The first minutes in the life of a peroxisomal matrix protein
... can import oligomeric proteins why then should this not be the regular pathway? After all, if a single PEX5 molecule could transport an oligomeric protein to the peroxisomal ... See full document
26
A cell-free organelle-based in vitro system for studying the peroxisomal protein import machinery
... a PEX5-centered in vitro import assay performed in presence ubiquitin aldehyde (Ubal; see Table 1) and either ATP or the non-hydrolysable analogue ...AMP-PNP. The experiment clearly ... See full document
37
The PEX5/PEX7 - mediated import of PTS2 - containing matrix proteins: mechanistics insights on PEX7 translocation and recycling steps
... why PEX5 is ubiquitinated at a cysteine residue instead of the more classical lysine residue ...of the conserved cysteine residue in PEX5 by a lysine results in a seemingly normal ... See full document
102
Factors involved in ubiquitination and deubiquitination of PEX5, the peroxisomal shuttling receptor
... to the PTS1, which remains intact upon import, the PTS2 is generally cleaved in the peroxisomal matrix by a serine protease (Kurochkin et ...all peroxisomal matrix ... See full document
19
Characterization of the mechanisms of protein translocation across the mammalian peroxisomal membrane
... all the advances made in recent years, there are still many aspects of this protein import pathway that remain ...regards the quaternary structure of the PEX5-cargo ... See full document
101
Mapping of the cargo protein membrane translocation step into the PEX5 cycling pathway.
... in the eukaryotic kingdom characterized by a single membrane and a dense protein matrix comprising a large set of enzymes ...in the metabolism of lipids, ethanol and glyoxylate, in the ... See full document
86
A single peroxisomal targeting signal mediates matrix protein import in diatoms.
... although the bulk of our knowledge about peroxisomes has been generated from only a handful of model ...organisms. Peroxisomal matrix proteins are synthesized cytosolically and posttranslationally ... See full document
9
The peroxisomal protein import pathway: a functional study of the N-terminal half of PEX5
... for the transport of de novo synthesized proteins that are destined for the peroxisome ...matrix. PEX5 has a modular structure characterized by i) an N-terminal half with little ... See full document
86
The peroxisomal protein import machinery displays a preference for monomeric substrates
... on the general properties of the PIM is fairly detailed, there are still many fundamental aspects of this protein import pathway that remain ...regards the structure of the cargo ... See full document
13
A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway
... Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery 645. components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs 646[r] ... See full document
43
Ubiquination and deubiquitination in the mammalian pex5-mediated peroxisomal protein import pathway.
... of the E2(s) mediating this ubiquitination event was an immediate ...cerevisiae the occurrence of PEX4-dependent monoubiquitination at the conserved N-terminal cysteine of PEX5 had been ... See full document
91
PEX5, the Shuttling Import Receptor for Peroxisomal Matrix Proteins, Is a Redox-Sensitive Protein
... S-labeled PEX5 and PEX5C11K were synthesized in rabbit reticulocyte lysates using the TNT®quick coupled transcription/translation system (Promega) in the presence of EasyTag™ L- ( 35 S)methionine ... See full document
15
Matrix Gla Protein expression pattern in the early avian embryo
... at the moment of the onset of circulation, MGP expres- sion can still be seen on what appears to be the anterior part of the dorsal ...along the first 7 somites ...that the ... See full document
7
Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator
... at the NPC during interphase in human ...with the nuclear envelope until prometaphase ( ...with the mitotic spindle from late prometaphase until anaphase and is recruited to the reforming ... See full document
11
The human metapneumovirus matrix protein stimulates the inflammatory immune response in vitro.
... recently, the hMPV glycoprotein G has been identified as a potential inhibitor of the IFN production in airway epithelial ...IFN. The hMPV glycoprotein G has been identified as an important virulence ... See full document
10
Matrix Support in mental health: the perspective of the experts on the work process
... ABSTRACT The article discusses decentralization in mental health through the Matrix Support in Primary Health Care ...(PHC). The research had as general objective to investigate the ... See full document
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