[PDF] Top 20 In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.
Has 10000 "In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling." found on our website. Below are the top 20 most common "In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.".
In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.
... form of the proteasome is the 26S complex, which is composed of two major subcomplexes: the 19S regulatory particle and the 20S proteolytic core particle (reviewed in ...[15]). RNAi-mediated ... See full document
15
A genome-wide RNAi screen identifies regulators of cholesterol-modified hedgehog secretion in Drosophila.
... identify genes required for secretion and release of Hh we performed an RNAi screen in Drosophila ...Hh. In addition, S2 cells can produce Hh multimers with similar size ... See full document
15
A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation.
... p38 in mouse embryonic stem cells upon depletion of Dusp1, indicating its effects are likely via ...Fluctuations in both Dusp1 and Dusp6 levels occur upon ERK pathway activation in ES cells, ... See full document
15
A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation.
... regulator of mRNA translation in all eukaryotic cells, is strongly activated in most ...genome-wide RNAi screen in a human cancer cell line, seeking genes that regulate S6 ... See full document
26
Establishing an in vivo assay system to identify components involved in environmental RNA interference in the western corn rootworm.
... discovery of environmental RNA interference (RNAi), in which gene expression is suppressed via feeding with double- stranded RNA (dsRNA) molecules, opened the door to the practical application ... See full document
15
RNA Sequencing Reveals the Alteration of the Expression of Novel Genes in Ethanol-Treated Embryoid Bodies.
... list of TFs would be a very helpful asset in the study of early embryonic development in aspect of with or without ...mode of regulation is still unknown, and further in- ... See full document
19
In vivo imaging of Hedgehog pathway activation with a nuclear fluorescent reporter.
... localization of mCherry-NLS reporter would allow the rapid detection of Hh pathway activation in individual cells; addition of the destabilizing domain would enhance reporter turnover and help ... See full document
8
Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells.
... inhibitor of apoptosis proteins (IAPs) in death receptor signaling [23] and the role Hedgehog in cellular survival, we first ascertained if inhibiting Smoothened (SMO), the ... See full document
10
In the absence of Sonic hedgehog, p53 induces apoptosis and inhibits retinal cell proliferation, cell-cycle exit and differentiation in zebrafish.
... differentiation in the shh 2/2 mutant, retinal sections of wild-type, shh 2/2 and p53 2/2 shh 2/2 mutant embryos were stained for markers of retinal cell ...cells in the wild-type (Fig. 9A-a), ... See full document
18
Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal.
... incidence of pancreatic cancer and other ...number of tumors of various ...ity of 82% ...a novel candidate for chemopre- vention ...inhibition of NFKB ...expression of ... See full document
10
Debra, a protein mediating lysosomal degradation, is required for long-term memory in Drosophila.
... goal of neuroscience is to understand how neural circuits encode memory and guide behavior ...Many of the molecular mechanisms underlying memory are conserved from flies to mammals, and Drosophila has been ... See full document
9
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions.
... many of which are not yet linked to the physical map. We used the RNAi phenotypes obtained with the genome-wide screens to test whether we could systematically clone genes that are mutated in ... See full document
8
Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.
... interpretation of putative kinase domain muta- tions, we created a prototype mutation interpretation tool for tyrosine kinases (TKs), called ‘‘Mutagrator’’, located at http:// ...it in the context of ... See full document
8
Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation.
... occupancy of CG1832, we generated a polyclonal antibody that targets the N-terminus of the protein (see ...protein of the predicted size and its RNAi knockdown strongly reduces its protein and ... See full document
11
SnRK1β1 interacting proteins: a new approach to the SnRK1 function
... concentrations of 5’-AMP are able to inhibit the T-loop dephosphorylation of the spin- ach SnRK1 kinase (Sugden et ...integrators of the transcriptome in response to darkness events, sugar ... See full document
91
Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes.
... misexpression of target genes that are commonly upregulated in both single mutants (Figure ...control RNAi, glp-4; hpl-2 mutant animals treated with lin-35(RNAi) displayed higher levels ... See full document
19
Identification of neural outgrowth genes using genome-wide RNAi.
... seen in the control (Figure 5A left panel). The number of branching points per neuron increased significantly ...3.262.5 in the control to 11.563.6 (Figure 5D). We also analyzed the effect of ... See full document
17
Computational discovery of transcriptional regulatory modules in fungal ribosome biogenesis genes reveals novel sequence and function patterns.
... involved in ribosome biogenesis and assembly (RBA) are responsible for ribosome ...formation. In Saccharomyces cerevisiae, their transcription is regulated by two dissimilar DNA ...interested in ... See full document
11
Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling.
... requirements of Krz during the development of the fly wing, we constructed flies with wings homozygous for a krz deficiency (Figure ...elimination of Krz in the wing pouch (in 638- ... See full document
15
Re-inspection of small RNA sequence datasets reveals several novel human miRNA genes.
... out of the 112 suggested miRNAs have reads positioned both on the 3 p and 5 p arm which is normally seen as strong bioinformatic ...However, in two cases (candidate 41 and candidate 101) we failed to pick ... See full document
3
temas relacionados