[PDF] Top 20 Translocating the blood-brain barrier using electrostatics
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Translocating the blood-brain barrier using electrostatics
... and the solvent was removed to yield a lipid ...for the contributions of hydrophobic and electrostatic interactions, membrane fluidity, and phase separation, or can even be prepared directly from lipids ... See full document
7
Treatment with the NK1 antagonist emend reduces blood brain barrier dysfunction and edema formation in an experimental model of brain tumors.
... in the disruption of the blood-brain barrier (BBB) and development of cerebral edema in acute brain ...around brain tumors and has been linked to several tumor-associated ... See full document
7
Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis.
... and the within-subject factor ‘‘time’’ (before ...assess the decrease in T1 values after Gd-DTPA injection in each group or by two-sided independent-samples t-tests to assess differences in T1-values ... See full document
9
Drug Delivery Across Blood-Brain-Barrier by Means of I.V. Administration of Lipid Nanoparticles.
... to the targets within the CNS is the employment of colloidal ...carriers. The achievements and drawbacks of brain delivery using nanoparticles have been discussed in several ... See full document
321
Opiates Upregulate Adhesion Molecule Expression in Brain MicroVascular Endothelial Cells (BMVEC): Implications for Altered Blood Brain Barrier (BBB) Permeability
... measured using a colometric assay. This assay determines total NO based on the enzymatic conversion of nitrate to nitrite by nitrate ...reduction. The reaction was followed by a colorimetric ... See full document
9
A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells.
... and the total amount of RNA was extracted with RNeasy Mini Kit (Qiagen), according to manufacturer’s ...(G2943CA), using an Agilent RNA 6000 Nano Kit ...gies). The microarrays were scanned by an ... See full document
11
Development and characterization of a co-culture two-dimensional blood-brain barrier for the study of nanoparticle permeation
... although the most frequently used models derive from rats ...are the porcine and bovine ...in the early 1980s and contain excellent characteristics for the study of the developmental ... See full document
81
Implementation of an in vitro blood-brain barrier model to study nanoparticle administration in stroke
... importantly, the barrier morphology seemed to change over time. On the first days of culture, the cell monolayer only presented small gaps which, over time, turn into bigger holes and, ... See full document
149
Flavonoid bioactivity: transport across blood-brain-barrier and neuroprotective effects. In vivo studies
... isolated using RNA-STAT 60 reagent (AMS Biotechnology, UK) according with manufacturer's ...at the end of the 72°C for 10 s segment) repeated for 55 cycles, and a final melting 95°C 10 sec, 65°C 60 ... See full document
113
Fingolimod prevents blood-brain barrier disruption induced by the sera from patients with multiple sclerosis.
... from the PBS-washed cells and single-stranded cDNA was prepared from 120 ng of total ...RNA. The samples were subjected to a PCR analysis, and the standard reaction curves were analyzed as previously ... See full document
12
Sex-specific signaling in the blood-brain barrier is required for male courtship in Drosophila.
... to using the flies in courtship crosses, we removed the y mutation by ...from the Bloomington Drosophila stock Figure ...show the courtship index CI (fraction of time males spend ... See full document
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Preservation of the blood brain barrier and cortical neuronal tissue by liraglutide, a long acting glucagon-like-1 analogue, after experimental traumatic brain injury.
... determined using the Evans blue dye extravasation as de- scribed previously ...hour, the rats were perfused transcardially with a minimum of 400 ml saline through the left ventricle until ... See full document
17
Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor.
... assay. The levels of cyto- kines in CSF, including IL-1b, IL-6, TNF-a, MCP-1 (CCL2), MIP-1a (CCL3), and RANTES (CCL5), were examined using the CBA assay (BD Biosciences, San Diego, CA) according to ... See full document
17
Permeability of the blood-brain barrier through the phases of ischaemic stroke and relation with clinical outcome: protocol for a systematic review
... assess the BBBP in ...extract the data and assess the risk of bias of the selected ...following the guidelines provided by Cochrane Handbook for Systematic Reviews of ...evidence ... See full document
7
Spatiotemporal correlations between blood-brain barrier permeability and apparent diffusion coefficient in a rat model of ischemic stroke.
... and the other at 48 ...representing the early (3 h) and delayed BBB disruption (48 h) in this rat stroke model ...in the studied parameters at these time points between the two groups ... See full document
9
Pharmacokinetic analysis of 111 in-labeled liposomal Doxorubicin in murine glioblastoma after blood-brain barrier disruption by focused ultrasound.
... Malignant brain tumors remain difficult to treat using chemotherapy because the blood-tumor barrier (BTB) limits the amount of potent agents that can be delivered to the ... See full document
7
Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke
... advancing the suture a defined distance (21–22 mm) from the common ca- rotid artery ...Then, the animals were allowed to awaken from anesthesia and returned to their ...with the same anes- ... See full document
17
Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells.
... also the gene most commonly reported to be impervious to pro-inflammatory stimuli in endothelial cells, as recently reported for human endothelial cells of the umbilical vein, choroid, and retina ...of ... See full document
22
West Nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model.
... directly using neutralizing antibodies or by blocking upstream signaling in animal models is being proposed as an attractive and feasible strategy for therapeutic intervention of reducing transendothelial ... See full document
12
A new noncanonical anionic peptide that translocates a cellular blood-brain barrier model
... in the development of new therapeutic agents, since they are able to carry therapeutic molecules across cell membranes and occasionaly through an endothelium, such as the BBB, with no significant cellular ... See full document
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