[PDF] Top 20 In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases.
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In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases.
... DNA methylation outside of the CpG context was initially detected in mESCs using nearest neighbour ...context and pointed towards a Dnmt3a dependency ...identified ... See full document
11
Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease: a pilot study.
... stage in the progression of the disease, thus reducing the survival chances of the ...patients. Non-invasive early detection would greatly enhance therapy and survival ...investigated ... See full document
12
Cardiac Myocyte De Novo DNA Methyltransferases 3a/3b Are Dispensable for Cardiac Function and Remodeling after Chronic Pressure Overload in Mice.
... regulators of development and disease [1,2]. For long time, DNA methylation was mostly considered to be a stable repressive epigenetic mark in somatic ...now DNA ... See full document
16
Open Análise de metilação de DNA nos genes da citoqueratina 14 e 19 em amostras de pele exposta e não exposta ao sol
... DNA Methylation- Gold kit, according to the manufacturer’s ...100ng of bisulphite modified DNA, 1µL (10 µM) of each primer and 1x Go Taq Hot Start Green Master Mix (Promega ... See full document
43
Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State
... transcription of epigenetically-defined biomarker genes perturbs the hESC epigenome at a global ...treatments of siRNA 24 hours apart as described ...(5-mC) and 5-hydroxymethylcytosine (5-hmC) showed ... See full document
24
DNA methylation of specific CpG sites in the promoter region regulates the transcription of the mouse oxytocin receptor.
... presented in this study shows both in vitro and in vivo that transcription of the mouse Oxtr is directly regulated by methylation of its promoter, in ... See full document
11
Gene Expression and DNA Methylation Status of Glutathione S-Transferase Mu1 and Mu5 in Urothelial Carcinoma.
... types and one SV40-transformed normal cell ...gene and mRNA, while 6 other cancer cell lines and SV-HUC1 belonged to the GSTM1-null genotype (Fig ...present in T24 cells, the anti-GSTM1 ... See full document
12
Tissue distribution of a plasmid DNA encoding Hsp65 gene is dependent on the dose administered through intramuscular delivery
... plasmid DNA used in genetic vaccines pos- sesses an SV40 sequence of replication and could replicate in ...synthesis of plasmid DNA in mamma- lian cells can be ... See full document
10
Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression.
... Univariate and multivariate GLM were used to explore associations between trajectories of aggression and ...all of these GLM, participants were statistically weighted according to the ... See full document
8
Characterization of Dnmt1 Binding and DNA Methylation on Nucleosomes and Nucleosomal Arrays.
... unit of chromatin is the nucleosome, composed of 147 bp of DNA wrapped around an octamer of H2A, H2B, H3 and H4 core histone ...access of regula- tory proteins to ...for ... See full document
22
Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers
... methylated CpG sites (5 hypermethylated, 4 hypomethy- lated) (Table 1). All 9 CpG sites were able to distinguish breast tumor tissue from normal tissue (AUC > ...0.8 and p < 0.0001, Table 1). ... See full document
12
DNA methylation modulates H19 and
... expression by IGF2 DMRs (Murrell et ...DMRs and IGF2 DMR1 are both unmethylated, H19 promoters in close proximity become ...DMRs and IGF2 DMR1 results in H19 expression. In ... See full document
7
Immune responses to gp82 provide protection against mucosal Trypanosoma cruzi infection
... with control or anti-gp82 specific monoclonal antibodies and then either placed on the conjunctiva of anesthetized mice (A) or fed orally to BALB/c mice (B, ...C). DNA ex- tracted 11-13 days ... See full document
5
Detection of differentially methylated regions of irradiated fig tree selections
... identified CpG islands, but with 3 dif- ferentially methylated sites amongst the treatments, as can be seen in Figure ...the control (Rodrigues et ...unique and diverge from the other ... See full document
9
Immune response in hamsters immunised with a recombinant fragment of LigA from Leptospira interrogans, associated with carrier molecules
... used in com- bination with immunostimulatory adjuvants; therefore, we supplemented the vaccine formulation with CpG ODNs to determine whether the immune response could be improved (Bianco et ...The ... See full document
5
Avaliação do padrão de metilação de regiões promotoras dos genes ESR1, ESR2 e PGR na endometriose profunda intestinal
... factors in the development of complex human disorders, including cancer and neurodegenerative, neurological and autoimmune diseases ...Changes in chromatin conformation are the basis ... See full document
86
Human Vav1 expression in hematopoietic and cancer cell lines is regulated by c-Myb and by CpG methylation.
... levels in Jurkat T cells, somewhat lower levels in H441 lung cancer cells, and not at all in the H460 lung cancer cell line ...expression of c-Myb and Vav1 may be correlated ... See full document
11
Methylation profiles reveal distinct subgroup of hepatocellular carcinoma patients with poor prognosis.
... one of the leading causes of cancer-associated mortality ...role of epigenetic changes such as aberrant DNA methylation in hepatocarcinogenesis remains largely ...unclear. ... See full document
10
Alterações epigenéticas em adenocarcinomas de próstata
... Clinicopathological features of the prostate carcinoma (PCa) and non-neoplastic prostate (NNP) patients from Group I evaluated by DNA methylation and protein expression (IHC) analyses[r] ... See full document
140
Morphological changes of Paulownia seedlings infected phytoplasmas reveal the genes associated with witches' broom through AFLP and MSAP.
... attack by modifying gene expres- sion. DNA methylation is one of the mechanisms in regulating gene expressions [30], similar results were also reported in Tomato Yellow Leaf Curl ... See full document
9
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