3 Material e Métodos
ASSOCIAÇÃO BRASILEIRA DE NORMAS TÉCNICAS NBR 6023: Informação e documentação: referências: elaboração Rio de Janeiro: 2002.
NATIONAL LIBRARY OF MEDICINE. List of journals indexed in Index Medicus. 2006. Available from: http://www.ncbi.nlm.nih.gov/entrez/;
Referências Bibliográficas ARANA, F. E.; PÉREZ-VICTORIA, J. M.; REPETTO, Y.; MORELLO, A.; CASTANYS, S.; GAMARRO, F. Involvement of thiol metabolism in resistance to glucantime in Leishmania tropica. Biochem. Pharmacol., v. 56, n. 9, p. 1201- 1208, 1998.
ARAUJO-SANTOS, J. M.; PARODI-TALICE, A.; CASTANYS, S.; GAMARRO, F. The overexpression of an intracellular ABCA-like transporter alters phospholipid trafficking in Leishmania. Biochem. Biophys. Res. Commun., v. 330, n. 1, p. 349-355, 2005.
ARMSTRONG, T. C.; PATTERSON, J. L. Cultivation of Leishmania braziliensis in an economical serum-free medium containing human urine. J. Parasitol., v. 80, n. 6, p. 1030-1032, 1996.
ASHFORD, R. W. The leishmaniases as emerging and reemerging zoonoses.
Int. J. Parasitol., v. 30, n. 12-13, p. 1269-1281, 2000.
ASHFORD, R. W.; DESJEUX, P.; DE RAADT, P. Estimation of population at risk of infection and number of cases of leishmaniasis. Parasitol. Today, v. 8, n. 3, p. 104-105, 1992.
AUSUBEL, F. M.; BRENT, R.; KINGSTON, R. E.; MOORE, D. D.; SEIDMAN, J. G.; SMITH, J. A.; STRUHL, K. Current Protocols in Molecular Biology. 4 ed. New York: John Wiley and Sons, 1995.
AZEREDO-COUTINHO, R. B.; CONCEICAO-SILVA, F.; SCHUBACH, A.; CUPOLILLO, E.; QUINTELLA, L. P.; MADEIRA, M. F.; PACHECO, R. S.; VALETE-ROSALINO, C. M.; MENDONCA, S. C. First report of diffuse cutaneous leishmaniasis and Leishmania amazonensis infection in Rio de Janeiro State, Brazil. Trans. R. Soc. Trop. Med. Hyg., v. 101, n. 7, p. 735-737, 2007.
BALANÃ-FOUCE, R.; REGUERA, R. M.; CUBRIA, J. C.; ORDONEZ, D. The pharmacology of leishmaniasis. Gen. Pharmacol., v. 30, n. 4, p. 435-443, 1998.
BARROS, H.C.; VERBISCK, N. V.; DA SILVA, S; ARAGUTH, M. F.; MORTARA, R. A. Distribution of epitopes of Trypanosoma cruzi amastigotes during the intracellular life cycle within mammalian cells. J. Eukaryot.
Microbiol., v. 44, n. 4, p. 332-344, 1997.
BASSELIN, M.; BADET-DENISOT, M. A.; LAWRENCE, F.; ROBERT-GERO, M. Effects of pentamidine on polyamine level and biosynthesis in wild-type, pentamidine-treated, and pentamidine-resistant Leishmania. Exp. Parasitol., v. 85, n. 3, p. 274-282, 1997.
Referências Bibliográficas BASSELIN, M.; BADET-DENISOT, M. A.; ROBERT-GERO, M. Modification of kinetoplast DNA minicircle composition in pentamidine-resistant Leishmania.
Acta Trop., v. 70, n. 1, p. 43-61, 1998.
BASSELIN, M.; DENISE, H.; COOMBS, G. H.; BARRETT, M. P. Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion. Antimicrob. Agents Chemother., v. 46, n. 12, p. 3731-3738, 2002.
BASSELIN, M.; LAWRENCE, F.; ROBERT-GERO, M. Altered transport properties of pentamidine-resistant Leishmania donovani and L. amazonensis promastigotes. Parasitol. Res., v. 83, n. 5, p. 413-418, 1997.
BASSELIN, M.; ROBERT-GERO, M. Alterations in membrane fluidity, lipid metabolism, mitochondrial activity, and lipophosphoglycan expression in pentamidine resistant Leishmania. Parasitol. Res., v. 84, n. 1, p. 78-83, 1998. BELLO, A. R.; NARE, B.; FREEDMAN, D.; HARDY, L.; BEVERLEY, S. M. PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. Proc. Natl. Acad. Sci.
U.S.A., v. 91, n. 24, p. 11442-11446, 1994.
BERMAN, J. D. Human leishmaniasis: Clinical, diagnostic, and chemotherapeutic developments in the last 10 years. Clin. Infect. Dis., v. 24, n. 4, p. 684-703, 1997.
BERMAN, J. D.; GALLALEE, J. V.; HANSEN, B. D. Leishmania mexicana: uptake of sodium stibogluconate (Pentostam) and pentamidine by parasite and macrophages. Exp. Parasitol., v. 64, n. 1, p. 127-131, 1987.
BEVERLEY, S. M. Gene amplification in Leishmania. Annu. Rev. Microbiol., v. 45, p. 417-444, 1991.
BEVERLEY, S. M.; CLAYTON, C. E. Transfection of Leishmania and Trypanosoma brucei by electroporation. In: HYDE, J. E. Protocols in Molecular Parasitology. Totowa: Humana Press, 1993. p. 333-348
BEVERLEY, S. M.; CODERRE, J. A.; SANTI, D. V.; SCHIMKE, R. T. Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization. Cell, v. 38, n. 2, p. 431-439, 1984.
BORST, P.; OUELLETTE, M. New mechanisms of drug resistance in parasitic protozoa. Annu. Rev. Microbiol., v. 49, p. 427-460, 1995.
Referências Bibliográficas BRAY, P. G.; BARRETT, M. P.; WARD, S. A.; DE KONING, H. P. Pentamidine uptake and resistance in pathogenic protozoa: past, present and future.Trends
Parasitol., v. 19, n. 5, p. 232-239, 2003.
BRONNER, U.; DOUA, F.; ERICSSON, O.; GUSTAFSSON, L. L.; MIEZAN, T. W.; RAIS, M.; ROMBO, L. Pentamidine concentrations in plasma, whole blood and cerebrospinal fluid during treatment of Trypanosoma gambiense infection in Cote d'Ivoire. Trans. R. Soc. Trop. Med. Hyg., v. 85, n. 5, p. 608-611, 1991. BRUN, R.; SCHÖNENBERGER, Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Acta Trop., v. 36, n. 3, p. 289-292, 1979.
CALLAHAN, H. L.; BEVERLEY, S. M. Heavy metal resistance: a new role for P- glycoproteins in Leishmania. J. Biol. Chem., v. 266, n. 28, p. 18427-18430, 1991.
CALLAHAN, H. L.; BEVERLEY, S. M. A member of the aldoketo reductase family confers methotrexate resistance in Leishmania. J. Biol. Chem., v. 267, n. 34, p. 24165-24168, 1992.
CALLAHAN, H. L.; PORTAL, A. C.; DEVEREAUX, R.; GROGL, M. An axenic amastigote system for drug screening. Antimicrob. Agents Chemother., v. 41, n. 4, p. 818-822, 1997.
CARRIÓ, J.; PORTÚS, M. In vitro susceptibility to pentavalent antimony in Leishmania infantum strains is not modified during in vitro or in vivo passages but is modified after host treatment with meglumine antimoniate. BMC
Pharmacol., v. 2, p.11, 2002.
CARTER, K. C.; SUNDAR, S.; SPICKETT, C.; PEREIRA, O. C.; MULLEN, A. B. The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesis.
Antimicrob. Agents Chemother., v. 47, n. 5, p. 1529-1535, 2003.
CASTANYS-MUÑOZ, E.; ALDER-BAERENS, N.; POMORSKI, T.; GAMARRO, F.; CASTANYS, S. A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids. Mol. Microbiol., v. 64, n. 5, p. 1141-1153, 2007.
CHIQUERO, M. J.; OLMO, A.; NAVARRO, P.; RUIZ-PEREZ, L. M.; CASTANYS, S.; GONZALEZ-PACANOWSKA, D.; GAMARRO, F. Amplification of the H locus in Leishmania infantum. Biochim. Biophys. Acta., v. 1227, n. 3, p. 188-194, 1994.
Referências Bibliográficas CHIQUERO, M. J.; PÉREZ-VICTORIA, J. M.; O´VALLE, F.; GONZALEZ-ROS, J. M.; DEL MORAL, R. G.; FERRAGUT, J. A.; CASTANYS, S.; GAMARRO, F. Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line. Biochem. Pharmacol., v. 55, n. 2, p. 131-139, 1998.
CHOW, L. M.; WONG, A. K.; ULLMAN, B.; WIRTH, D. F. Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enriettii. Mol. Biochem. Parasitol., v. 60, n. 2, p. 195-208, 1993.
CHUNG, C. T.; MILLER, R. H. A rapid and convenient method for the preparation and storage of competent bacterial cells. Nucleic Acids Res., v. 16, n. 8, p. 3580, 1988.
CODERRE, J. A.; BEVERLEY, S. M.; SCHIMKE. R. T.; SANTI, D. V. Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proc. Natl.
Acad. Sci. U.S.A., v. 80, n. 8, p. 2132-2136, 1983.
COELHO, A. C. Caracterização de um gene de Leishmania major
relacionado com a resistência à pentamidina. 84 f. Dissertação (Mestrado
em Biologia da Relação Patógeno-Hospedeiro) – Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, 2002.
COELHO, A. C.; BEVERLEY, S. M.; COTRIM, P. C. Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major. Mol. Biochem. Parasitol., v. 130, n. 2, p. 83-90, 2003.
COTRIM, P. C.; GARRITY, L. K.; BEVERLEY, S. M. Isolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by overexpression/selection. J. Biol. Chem., v. 274, n. 53, p. 37723-37730, 1999.
CROFT, S. L. Monitoring drug resistance in leishmaniasis. Trop. Med. Int.
Health,v. 6, n. 11, p. 899-905, 2001.
CROFT, S. L. Recent developments in the chemotherapy of leishmaniasis.
Trends Pharmacol. Sci., v. 9, n. 10, p. 376-381, 1988.
CROFT, S. L.; BARRETT, M. P.; URBINA, J. A. Chemotherapy of trypanosomiases and leishmaniasis. Trends Parasitol., v. 21, n. 11, p. 508- 512, 2005.
Referências Bibliográficas CROFT, S. L.; BRAZIL, R. P. Effect of pentamidine isethionate on the ultrastructure and morphology of Leishmania mexicana amazonensis in vitro.
Ann. Trop. Med. Parasitol., v. 76, n. 1, p. 37-43, 1982.
CROFT, S. L.; COOMBS, G. H. Leishmaniasis - current chemotherapy and recent advances in the search for novel drugs. Trends Parasitol., v. 19, n. 11, p. 502-508, 2003.
CROFT, S. L.; SUNDAR, S.; FAIRLAMB, A. H. Drug resistance in Leishmaniasis. Clin. Microbiol. Rev., v. 19, n. 1, p. 111-126, 2006.
CRUZ, A. K.; BEVERLEY, S. M. Gene replacement in parasitic protozoa.
Nature, v. 348, n. 6297, p. 171-173, 1990.
CRUZ, A. K.; COBURN, C. M.; BEVERLEY, S. M. Double targeted gene replacement for creating null mutants. Proc. Natl. Acad. Sci. U.S.A., v. 88, n. 16, p. 7170-7174, 1991.
CUPOLILLO, E.; MEDINA-ACOSTA, E.; NOYES, H.; MOMEN, H.; GRIMALDI, G. JR. A revised classification for Leishmania and Endotrypanum. Parasitol.
Today, v. 16, n. 4, p. 142-144, 2000.
DA SILVA, R.; SACKS, D. L. Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuation. Infect. Immun., v. 55, n. 11, p. 2802-2806, 1987.
DALLAGIOVANNA, B.; GAMARRO, F.; CASTANYS, S. Molecular characterization of a P-glycoprotein-related tcpgp2 gene in Trypanosoma cruzi.
Mol. Biochem. Parasitol., v. 75, n. 2, p. 145-157, 1996.
DECUYPERE, S.; RIJAL, S.; YARDLEY, V.; DE DONCKER, S.; LAURENT, T.; KHANAL, B.; CHAPPUIS, F.; DUJARDIN, J. C. Gene expression analysis of the mechanism of natural resistance Sb(V) resistance in Leishmania donovani isolates from Nepal. Antimicrob. Agents Chemother., v. 49, n. 11, p. 4616- 4621, 2005.
DEELEY, R. G.; WESTLAKE, C.; COLE, S. P. Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol. Rev., v. 86, n. 3, p. 849-899, 2006.
DENTON, H.; MCGREGOR, J. C.; COOMBS, G. H. Reduction of anti- leishmanial pentavalent antimonial drugs by a parasite-specific thiol-dependent reductase, TDR1. Biochem. J., v. 381, n. 2, p. 405-412, 2004.
Referências Bibliográficas DESCOTEAUX, A.; GARRAWAY, L. A.; RYAN, K. A.; GARRITY, L. K.; TURCO, S. J.; BEVERLEY, S. M. Identification of genes by functional complementation in protozoan parasite Leishmania. In: ADOLPH, K. W.
Methods in Molecular Genetics. New York: Academic Press, 1994. p. 22-48.
DESJEUX, P. Leishmaniasis. Public health aspects and control. Clin.
Dermatol., v. 14, n. 5, p. 417-423, 1996.
DETKE, S. Identification of a transcription factor like protein at the TOR locus in Leishmania mexicana amazonensis. Mol. Biochem. Parasitol., v. 90, n. 2, p. 505-511, 1997.
DETKE, S. TOR-induced resistance to toxic adenosine analogs in Leishmania brought about by the internalization and degradation of the adenosine permease. Exp. Cell. Res., v. 313, n. 9, p. 1963-1978, 2007.
DEY, S.; OUELLETTE, M.; LIGHTBODY, J.; PAPADOPOULOU, B.; ROSEN, B. P. An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae. Proc. Natl. Acad. Sci. U.S.A., v. 93, n. 5, p. 2192-2197, 1996.
DEY, S.; PAPADOPOULOU, B.; HAIMEUR, A.; ROY, G.; GRONDIN, K.; DOU, D.; ROSEN, B. P.; OUELLETTE, M. High level arsenite resistance in Leishmania tarentolae is mediated by an active extrusion system. Mol. Biochem. Parasitol., v. 67, n. 1, p. 49-57, 1994.
DIAS, F. C.; RUIZ, J. C.; LOPES, W. C.; SQUINA, F. M.; RENZI, A.; CRUZ, A. K.; TOSI, L. R. Organization of H locus conserved repeats in Leishmania (Viannia) braziliensis correlates with lack of gene amplification and drug resistance. Parasitol. Res., 2007. In press.
DODGE, M. A.; WALLER, R. F.; CHOW, L. M. C.; ZAMAN, M. M.; COTTON, L. M.; MCCONVILLE, M. J.; WIRTH, D. F. Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites. Mol.
Microbiol., v. 51, n. 6, p. 1563-1575, 2004.
DUBE, A.; SINGH, N.; SUNDAR, S. Refractoriness to the treatment of sodium stibogluconate in Indian kala-azar field isolates persist in in vitro and in vivo experimental models. Parasitol. Res., v. 96, n. 4, p. 216-223, 2005.
EL FADILI, K.; MESSIER, N.; LEPROHON, P.; ROY, G.; GUIMOND, C.; TRUDEL, N.; SARAVIA, N. G.; PAPADOPOULOU, B.; LÉGARÉ, D.; OUELLETTE, M. Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes.
Referências Bibliográficas
ELLENBERGER, T. E.; BEVERLEY, S. M. Multiple drug resistance and conservative amplification of the H region in Leishmania major. J. Biol. Chem., v. 264, n. 25, p. 15094-15103, 1989.
ENDICOTT, J. A.; LING, V. The biochemistry of P-glycoprotein-mediated multidrug resistance.Annu. Rev. Biochem., v. 58, p. 137-171, 1989.
ESSODAIGUI, M.; FREZARD, F.; MOREIRA, E. S.; DAGGER, F.; GARNIER- SUILLEROT, A. Energy-dependent efflux from Leishmania promastigotes of substrates of the mammalian multidrug resistance pumps. Mol. Biochem.
Parasitol., v. 100, n. 1, p. 73-84, 1999.
FEDDERSEN, A.; SACK, K. Experimental studies on the nephrotoxicity of pentamidine in rats. J. Antimicrob. Chemother., v. 28, n. 3, p. 437-446, 1991. GAGNON, D.; FOUCHER, A.; GIRARD, I.; OUELLETTE, M. Stage specific gene expression and celullar localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania. Mol.
Biochem. Parasitol., v. 150, n. 1, p. 63-71, 2006.
GHEDIN, E.; DEBRABANT, A.; ENGEL, J. C.; DWYER, D. M. Secretory and endocytic pathways converge in a dynamic endosomal system in a primitive protozoan. Traffic, v. 2, n. 3, p. 175-188, 2001.
GLAUMANN, H.; BRONNER, U.; ERICSSON, O.; GUSTAFSSON, L. L.; ROMBO, L. Pentamidine accumulates in rat liver lysosomes and inhibits phospholipid degradation. Pharmacol. Toxicol., v. 74, n. 1, p. 17-22, 1994. GOTTESMAN, M. M.; PASTAN, I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem., v. 62, p. 385- 427, 1993.
GOURBAL, B.; SONUC, N.; BHATTACHARJEE, H.; LEGARE, D.; SUNDAR, S.; OUELLETTE, M.; ROSEN, B. P.; MUKHOPADHYAY, R. Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin. J. Biol.
Chem., v. 279, n. 30, p. 31010-31017, 2004.
GRÁCIO, M. A.; GRACIO, A. J.; VIVEIROS, M.; AMARAL, L. Since phenothiazines alter antibiotic susceptibility of microorganisms by inhibiting efflux pumps, are these agents useful for evaluating similar pumps in phenothiazine-sensitive parasites? Int. J. Antimicrob. Agents, v. 22, n. 3, p. 347-351, 2003.
Referências Bibliográficas GRONDIN, K.; HAIMEUR, A.; MUKHOPADHYAY, R.; ROSEN, B. P.; OUELLETTE, M. Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae. EMBO J., v. 16, n. 11, p. 3057-3065, 1997.
GRONDIN, K.; PAPADOPOULOU, B.; OUELLETTE, M. Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania. Nucleic Acids Res., v. 21, n. 8, p. 1895-1901, 1993.
GRONDIN, K.; ROY, G.; OUELLETTE, M. Formation of extrachromosomal circular amplicons with direct or inverted duplications in drug-resistant Leishmania tarentolae. Mol. Cell. Biol., v. 16, n. 7, p. 3587-3595, 1996.
GUEIROS-FILHO, F. J.; VIOLA, J. P.; GOMES, F. C.; FARINA, M.; LINS, U.; BERTHO, A. L.; WIRTH, D. F.; LOPES, U. G. Leishmania amazonensis: multidrug resistance in vinblastine-resistant promastigotes is associated with rhodamine 123 efflux, DNA amplification, and RNA overexpression of a Leishmania mdr1 gene. Exp. Parasitol., v. 81, n. 4, p. 480-490, 1995.
GUEVARA, P.; PINTO-SANTINI, D.; ROJAS, A.; CRISANTE, G.; ANEZ, N.; RAMIREZ, J. L. Green fluorescent protein-tagged Leishmania in phlebotomine sand flies. J. Med. Entomol., v. 38, n. 1, p. 39-43, 2001.
GUIMOND, C.; TRUDEL, N.; BROCHU, C.; MARQUIS, N.; EL FADILI, K. PEYTAVI, R.; BRIAND, G. RICHARD, D.; MESSIER, N.; PAPADOPOULOU, B.; CORBEIL, J.; BERGERON, M. G.; LÉGARÉ, D.; OUELLETTE, M. Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays. Nucleic Acids Res., v. 31, n. 20, p. 5886-5896, 2003.
HA, D. S.; SCHWARZ, J. K.; TURCO, S. J.; BEVERLEY, S. M. Use of green fluorescent protein as a marker in transfected Leishmania. Mol. Biochem.
Parasitol., v. 77, n. 1, p. 57-64,1996.
HADIGHI, R.; MOHEBALI, M.; BOUCHER, P.; HAJJARAN, H.; KHAMESIPOUR, A.; OUELLETTE, M. Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites. PLoS Med., v. 3, n. 5, p. e162, 2006.
HAIMEUR, A.; OUELLETTE, M. Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate. Antimicrob. Agents
Referências Bibliográficas HAIMEUR, A; GUIMOND, C.; PILOTE, S.; MUKHOPADHYAY, R.; ROSEN, B. P.; POULIN, R.; OUELLETTE, M. Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania. Mol. Microbiol., v. 34, n. 4, p. 726-735, 1999.
HAMADA, H; TSURUO, T. Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase. J. Biol. Chem., v. 263, n. 3, p. 1454- 1458, 1988.
HANSON, S.; ADELMAN, J.; ULLMAN, B. Amplification and molecular cloning of the ornithine decarboxylase gene of Leishmania donovani. J. Biol. Chem., v. 267, n. 4, p. 2350-2359, 1992.
HE, S.; FOX, T. D. Mutations affecting a yeast mitochondrial inner membrane protein, pnt1p, block export of a mitochondrially synthesized fusion protein from the matrix. Mol. Cell. Biol., v. 19, n. 10, p. 6598-6607, 1999.
HENDERSON, D. M.; SIFRI, C. D.; RODGERS, M.; WIRTH, D. F.; HENDRICKSON, N.; ULMAN, B. Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene. Mol. Cell. Biol., v. 12, n. 6, p. 2855-2865, 1992.
HENDRICKSON, N.; SIFRI, C. D.; HENDERSON, D. M.; ALLEN, T.; WIRTH, D. F.; ULLMAN, B. Molecular characterization of the ldmdr1 multidrug resistance gene from Leishmania donovani. Mol. Biochem. Parasitol., v. 60, n. 1, p. 53- 64, 1993.
HENTZER, B.; KOBAYASI, T. The ultrastructural changes of Leishmania tropica after treatment with pentamidine. Ann. Trop. Med. Parasitol., v. 71, n. 2, p. 157-166, 1977.
HERWALDT, B. L. Leishmaniasis. Lancet, v. 354, n. 9185, p. 1191-1199, 1999. HIGGINS, C. F. ABC transporters: from microorganisms to man. Annu. Rev.
Cell Biol., v. 8, p. 67-113, 1992.
IOVANNISCI, D. M.; KAUR, K.; YOUNG, L.; ULLMAN, B. Genetic analysis of nucleoside transport in Leishmania donovani. Mol. Cell. Biol., v. 4, n. 6, p. 1013-1019, 1984.
IVENS, A. C.; PEACOCK, C. S.; WORTHEY, E. A.; MURPHY, L.; AGGARWAL, G.; BERRIMAN, M.; SISK, E.; RAJANDREAM, M. A.; ADLEM, E.; AERT, R.;
Referências Bibliográficas ANUPAMA, A.; APOSTOLOU, Z.; ATTIPOE, P.; BASON, N.; BAUSER, C.; BECK, A.; BEVERLEY, S. M.; BIANCHETTIN, G.; BORZYM, K.; BOTHE, G.; BRUSCHI, C. V.; COLLINS, M.; CADAG, E.; CIARLONI, L.; CLAYTON, C.; COULSON, R. M. R.; CRONIN, A.; CRUZ, A. K.; DAVIES, R. M.; DE GAUDENZI, J.; DOBSON, D. E.; DUESTERHOEFT, A.; FAZELINA, G.; FOSKER, N.; HARRIS, D.; HERTZ-FOWLER, C.; HILBERT, H.; HORN, D.; HUANG, Y.; KLAGES, S.; KNIGHTS, A.; KUBE, M.; LARKE, N.; LITVIN, L.; LORD, A.; LOUIE, T.; MARRA, M.; MASUY, D.; MATTHEWS, K.; MICHAELI, S.; MOTTRAM, J. C.; MÜLLER-AUER, S.; MUNDEN, H.; NELSON, S.; NORBERTCZAK, H.; OLIVER, K.; O´NEIL, S.; PENTONY, M.; POHL, T. M.; PRICE, C.; PURNELLE, B.; QUAIL, M. A.; RABBINOWITSCH, E.; REINHARD, R.; RIEGER, M.; RINTA, J.; ROBBEN, J.; ROBERTSON, L.; RUIZ, J. C.; RUTTER, S.; SAUNDERS, D.; SCHÄFER, M.; SCHEIN, J.; SCHWARTZ, D. C.; SEEGER, K.; SEYLER, A.; SHARP, S.; SHIN, H.; SIVAM, D.; SQUARES, S.; TOSATO, V.; VOGT, C.; VOLCKAERT, G.; WANBUTT, R.; WARREN, T.; WEDLER, H.; WOODWARD, J.; ZHOU, S.; ZIMMERMANN, W.; SMITH, D. F.; BLACKWELL, J. M.; STUART, K. D.; BARREL, B.; MYLER, P. J. The genome of the kinetoplastid parasite, Leishmania major. Science, v. 309, n. 5733, p. 436-442, 2005.
JEAN-MORENO, V.; ROJAS, R.; GOYENECHE, D.; COOMBS, G. H.; WALKER, J. Leishmania donovani: Differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays. Exp. Parasitol., v. 112, n. 1, p. 21-30, 2006.
JHA, T.K.; SUNDAR, S.; THAKUR, C.P.; BACHMANN, P.; KARBWANG, J.; FISCHER, C.; VOSS, A.; BERMAN, J. Miltefosine, an oral agent for the treatment of Indian visceral leishmaniasis. N. Engl. J. Med., v. 341, n. 24, p.
1795-1800, 1999.
KAPLER, G. M.; BEVERLEY, S. M. Transcriptional mapping of the amplified region encoding the dihydrofolate reductase-thymidylate synthase of Leishmania major reveals a high density of transcripts, including overlapping and antisense RNAs. Mol. Cell. Biol., v. 9, n. 9, p. 3959-3972, 1989.
KAPLER, G. M.; COBURN, C. M.; BEVERLEY, S. M. Stable transfection of the human parasite Leishmania major delineates a 30 kilobases region sufficient for extrachromosomal replication and expression. Mol. Cell. Biol., v. 10, n. 3, p. 1084-1094, 1990.
KAPLER, G. M.; ZHANG, K.; BEVERLEY, S. M. Nuclease mapping and DNA sequence analysis of transcripts from the dihydrofolate reductase-thymidylate synthase (R) region of Leishmania major. Nucleic Acids Res., v.18, n. 21, p. 6399-6408, 1990.
Referências Bibliográficas KATAKURA, K.; FUJISE, H.; TAKEDA, K.; KANEKO, O.; TORII, M.; SUZUKI, M.; CHANG, K. P.; HASHIGUCHI, Y. Overexpression of LaMDR2, a novel multidrug resistance ATP-binding cassette transporter, causes 5-fluorouracil resistance in Leishmania amazonensis. FEBS Lett., v. 561, n. 1-3, p. 207-212, 2004.
KATAKURA, K.; IWANAMI, M.; OHTOMO, H.; FUJISE, H.; HASHIGUCHI, Y. Structural and functional analysis of the LaMDR1 multidrug resistance gene in Leishmania amazonensis. Biochem. Biophys. Res. Commun., v. 255, n. 2, p. 289-294, 1999.
KAUR, J.; DEY, C. S. Putative P-glycoprotein expression in arsenite-resistant Leishmania donovani down-regulated by verapamil. Biochem. Biophys. Res. Commun., v. 271, n. 3, p. 615-619, 2000.
KERBY, B.R.; DETKE, S. Reduced purine accumulation is encoded on an amplified DNA in Leishmania mexicana amazonensis resistant to toxic nucleosides. Mol. Biochem. Parasitol., v. 60, n. 2, p. 171-185, 1993.
KLOKOUZAS, A.; SHAHI, S.; HLADKY, S. B.; BARRAND, M. A.; VAN VEEN, H. W. ABC transporters and drug resistance in parasitic protozoa. Int. J.
Antimicrob. Agents, v. 22, n. 3, p. 301-317, 2003.
LAEMMLI, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, v. 227, n. 5259, p. 680-685, 1970.
LAGUNA, F. Treatment of leishmaniasis in HIV-positive patients. Ann. Trop.
Med. Parasitol., v. 97, n. 1, p. 135-142, 2003.
LEANDRO, C.; CAMPINO, L.; Leishmaniasis: efflux pumps and chemoresistance. Int. J. Antimicrob. Agents, v. 22, n. 3, p. 352-357, 2003.
LEBOWITZ, J. H.; COBURN, C. M.; MCMAHON-PRATT, D.; BEVERLEY, S. M. Development of a stable Leishmania expression vector and application to the study of parasite surface antigen genes. Proc. Natl. Acad. Sci. U.S.A., v. 87, n. 24, p. 9736-9740, 1990.
LÉGARÉ, D.; CAYER, S.; SINGH, A. K.; RICHARD, D.; PAPADOPOULOU, B.; OUELLETTE, M. ABC proteins of Leishmania. J. Bioenerg. Biomembr., v. 33, n. 6, p. 469-474, 2001a.
LÉGARÉ, D.; HETTEMA, E.; OUELLETTE, M. The P-glycoproteins-related gene family in Leishmania. Mol. Biochem. Parasitol., v. 68, n. 1, p. 81-91, 1994.
Referências Bibliográficas
LÉGARÉ, D.; PAPADOPOULOU, B.; ROY, G.; MUKHOPADHYAY, R.; HAIMEUR, A.; DEY, S.; GRONDIN, K.; BROCHU, C.; ROSEN, B. P.; OUELLETTE, M. Efflux systems and increased trypanothione levels in arsenite- resistant Leishmania. Exp. Parasitol., v. 87, n. 3, p. 275-282, 1997.
LÉGARÉ, D.; RICHARD, D.; MUKHOPADHYAY, R.; STIERHOF, Y. D.; ROSEN, B. P.; HAIMEUR, A.; PAPADOPOULOU, B.; OUELLETTE M. The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase. J. Biol. Chem., v. 276, n. 28, p. 26301-26307, 2001b.
LEPROHON, P.; LÉGARÉ, D.; GIRARD, I.; PAPADOPOULOU, B.; OUELLETTE, M. Modulation of Leishmania ABC protein gene expression through life stages and among drug-resistant parasites. Eukaryot. Cell, v. 5, n. 10, p. 1713-1725, 2006.
LEW, A. M.; BECK, D. J.; THOMAS, L. M. . Recombinant fusion proteins of protein A and protein G with glutathione S-transferase as reporter molecules. J.
Immunol. Methods, v.136, n. 2, p. 211-219, 1991.
LIRA, R.; SUNDAR, S.; MAKHARIA, A.; KENNEY, R.; GAM, A.; SARAIVA, E.; SACKS, D. Evidence that the high incidence of treatment failures in Indian kala- azar is due to the emergence of antimony-resistant strains of Leishmania donovani. J. Infect. Dis., v. 180, n. 2, p. 564-567, 1999.
LUDEWIG, G.; STABEN, C. Characterization of the PNT1 pentamidine resistance gene of Saccharomyces cerevisiae. Antimicrob. Agents
Chemother., v. 38, n. 12, p. 2850-2856, 1994.
LUX, H.; HEISE, N.; KLENNER, T.; HART, D.; OPPERDOES, F. R. Ether-lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether-lipid analogues in Leishmania. Mol. Biochem. Parasitol., v. 111, n. 1, p. 1-14, 2000. MAGILL, A. J. Epidemiology of leishmaniases. Dermatol. Clin., v. 13, n. 3, p. 505-523, 1995.
MARCHINI, J. F.; CRUZ, A. K.; BEVERLEY, S. M.; TOSI, L. R. The H region HTBF gene mediates terbinafine resistance in Leishmania major. Mol. Biochem. Parasitol., v. 131, n. 1, p. 77-81, 2003.
MARQUIS, N.; GOURBAL, B.; ROSEN, B. P.; MUKHOPADHYAY, R.; OUELLETTE, M. Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania. Mol. Microbiol., v. 57, n. 6, p. 1690-1699, 2005.
Referências Bibliográficas MARTIN, S. K.; ODUOLA, A. M. J.; MILHOUS, W. K. Reversal of chloroquine resistance in Plasmodium falciparum by verapamil. Science, v. 235, n. 4791, p. 899-901, 1987.
MASER, P.; KAMINSKY, R. Identification of three ABC transporter genes in Trypanosoma brucei spp. Parasitol. Res., v. 84, n. 2, p. 106-111, 1998.
MBONGO, N.; LOISEAU, P. M.; BILLION, M. A.; ROBERT-GERO, M. Mechanism of amphotericin B resistance in Leishmania donovani promastigotes. Antimicrob. Agents Chemother., v. 42, n. 2, p. 352-357, 1998. MCCONVILLE, M. J.; MULLIN, K. A.; ILGOUTZ, S. C.; TEASDALE, R. D. Secretory pathway of trypanosomatid parasites. Microbiol. Mol. Biol. Rev., v. 66, n. 1, p. 122-154, 2002.
MEDINA-ACOSTA, E.; CROSS, G. A. Rapid isolation of DNA from trypanosomatid protozoa using a simple 'mini-prep' procedure. Mol. Biochem.
Parasitol., v. 59, n. 2, p. 327-329, 1993.
MOREIRA, E. S.; ANACLETO, C.; PETRILLO-PEIXOTO, M. L. Effect of glucantime on field and patient isolates of New World Leishmania: use of growth parameters of promastigotes to assess antimony susceptibility.
Parasitol. Res., v. 84, n. 9, p. 720-726, 1998.
MUKHERJEE, A.; PADMANABHAN, P. K.; SAHANI, M. H.; BARRET, M. P.; MADHUBALA, R. Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani. Mol. Biochem. Parasitol., v. 145, n. 1, p. 1-10, 2006.
MUKHERJEE, A.; PADMANABHAN, P. K.; SINGH, S.; ROY, G.; GIRARD, I.; CHATTERJEE, M.; OUELLETTE, M.; MADHUBALA, R. Role of ABC transporter MRPA, {gamma}-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani. J.
Antimicrob. Chemother., v. 59, n. 2, p. 204-211, 2007.
MULLIN, K. A.; FOTH, B. J.; ILGOUTZ, S. C.; CALLAGHAN, J. M.; ZAWADZKI, J. L.; MCFADDEN, G. I.; MCCONVILLE, M. J. Regulated degradation of an endoplasmic reticulum membrane protein in a tubular lysosome in Leishmania mexicana. Mol. Biol. Cell., v. 12, n. 8, p. 2364-2377, 2001.
MURRAY, H. W.; BERMAN, J. D.; DAVIES, C. R.; SARAVIA, N. G. Advances in leishmaniasis. Lancet, v. 366, n. 9496, p. 1561-1577, 2005.
Referências Bibliográficas MURTA, S. M.; DOS SANTOS, W. G.; ANACLETO, C.; NIRDE, P.; MOREIRA, E. S.; ROMANHA, A. J. Drug resistance in Trypanosoma cruzi is not associated with amplification or overexpression of P-glycoprotein (PGP) genes. Mol.
Biochem. Parasitol., v. 117, n. 2, p. 223-228, 2001.
NATERA, S.; MACHUCA, C.; PADRON-NIEVES, M.; ROMERO, A.; DIAZ, E.; PONTE-SUCRE, A. Leishmania spp.: proficiency of drug-resistant parasites.
Int. J. Antimicrob. Agents, v. 29, n. 6, p. 637-642, 2007.
NEAL, R. A.; VAN BUEREN, J.; MCCOY, N. G.; IWOBI, M. Reversal of drug resistance in Trypanosoma cruzi and Leishmania donovani by verapamil.
Trans. R. Soc. Trop. Med. Hyg., v. 83, n. 2, p. 197-198, 1989.
OLLIARO, P. L.; BRYCESON, A. D. M. Practical progress and new drugs for changing patterns of leishmaniasis. Parasitol. Today, v. 9, n. 9, p. 323-328, 1993.
OLMO, A.; ARREBOLA, R.; BERNIER, V.; GONZALEZ-PACANOWSKA, D.; RUIZ-PEREZ, L. M. Co-existence of circular and multiple linear amplicons in methotrexate-resistant Leishmania. Nucleic Acids Res., v. 23, n. 15, p. 2856- 2864, 1995.
OUELLETTE, M. Biochemical and molecular mechanisms of drug resistance in parasites. Trop. Med. Int.. Health, v. 6, n. 11, p. 874-882, 2001.
OUELLETTE, M.; BORST, P. Drug resistance and P-glycoprotein gene amplification in the protozoan parasite Leishmania. Res. Microbiol., v. 142, n. 6, p. 737-746, 1991.
OUELLETTE, M.; DRUMMELSMITH, J.; PAPADOPOULOU, B. Leishmaniasis: drugs in the clinic, resistance and new developments. Drug Resist. Updat., v. 7, n. 4-5, p. 257-266, 2004.
OUELLETTE, M.; FASE-FOWLER, F.; BORST, P. The amplified H circle of methotrexate-resistant Leishmania tarentolae contains a novel P-glycoprotein gene. EMBO J., v. 9, n. 4, p. 1027-1033, 1990.
OUELLETTE, M.; HETTEMA, E.; WUST, D.; FASE-FOWLER, F.; BORST, P. Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania. Embo J., v. 10, n. 4, p. 1009-1016, 1991.
Referências Bibliográficas OUELLETTE, M.; LÉGARÉ. D.; HAIMEUR, A.; GRONDIN, K.; ROY, G.; BROCHU, C.; PAPADOPOULOU, B. ABC transporters in Leishmania and their role in drug resistance. Drug Resist. Updat., v. 1, n. 1, p. 43-48, 1998.
OUELLETTE, M.; PAPADOPOULOU, B. Mechanisms of drug resistance in Leishmania. Parasitol. Today, v. 9, n. 5, p. 150-153, 1993.
PAPADOPOULOU, B.; KUNDIG, C.; SINGH, A.; OUELLETTE, M. Drug resistance in Leishmania: similarities and differences to other organisms. Drug
Resist. Updat., v. 1, n. 4, p. 266-278, 1998.
PAPADOPOULOU, B.; ROY, G.; DEY, S.; ROSEN, B. P.; OLIVIER, M.; OUELLETTE, M. Gene disruption of the P-glycoprotein related gene pgpa of Leishmania tarentolae. Biochem. Biophys. Res. Commun., v. 224, n. 3, p.
772-778, 1996.
PAPADOPOULOU, B.; ROY, G.; DEY, S.; ROSEN, B. P.; OUELLETTE, M. Contribution of the Leishmania P-glycoprotein-related gene ltpgpA to oxyanion resistance. J. Biol. Chem., v. 269, n. 16, p. 11980-11986, 1994.
PAPADOPOULOU, B.; ROY, G.; OUELLETTE, M. Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania. Nucleic Acids Res., v. 21, n. 18, p. 4305- 4312, 1993.
PAPADOPOULOU, B; ROY, G.; OUELLETTE, M., A novel antifolate resistance gene on the amplified H circle of Leishmania. EMBO J., v. 11, n. 10, p. 3601- 3608, 1992.
PARODI-TALICE, A.; ARAUJO, J. M.; TORRES, C.; PEREZ-VICTORIA, J. M.; CASTANYS, S.; GAMARRO, F. The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity.