De acordo com os resultados encontrados neste estudo, pode-se concluir que o pré-tratamento com as cepas dos probióticos Lactobacillus plantarum CNPC003 e Lactobacillus mucosae CNPC007 foi capaz de atenuar o processo inflamatório intestinal induzido por DNBS em ratos, considerando que:
Melhorou os parâmetros clínicos da DII como representados no DAI;
Diminuiu parâmetros macroscópicos da DII como IDM e a relação peso/comprimento colônico;
Modulou o processo inflamatório intestinal reduzindo MPO, iNOS, MMP-9, a via de sinalização NF-κB, as citocinas pró-inflamatórias TNF-α, IL-β e IL-17, e aumentou a citocina anti-inflamatória IL-10;
Melhorou o estresse oxidativo colônico, reduzindo o MDA;
Aumentou a expressão de marcadores MUC-2, ZO-1 e OCL relacionados à integridade de barreira intestinal;
Com a provada eficácia das cepas LM CNPC007 e LP CNPC003 isoladas em promover a redução dos parâmetros inflamatórios intestinais, se faz importante a utilização de novos grupos experimentais para verificar o efeito sinérgico da interação destas cepas com o fármaco padrão SSZ em vista de gerar resultados superiores àqueles encontrados. Além disso, estudos adicionais são necessários para esclarecer os mecanismos exatos de interação entre as cepas e a sinalização celular da qual fazem parte diversos mediadores.
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ANEXO A – Cadastrado das espécies Lactobacillus plantarum CNPC003 e
Lactobacillus mucosae CNPC007 no Sistema Nacional de Gestão do
ANEXO B - Protocolo aprovado pelo Comitê de Ética no uso de animais (CEUA)/UFRN