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Activity blockade and GABAA receptor blockade produce synaptic scaling through chloride accumulation in embryonic spinal motoneurons and interneurons.

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Academic year: 2017

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Figure 1. Genetic expression of Clomeleon in embryonic chick spinal motoneurons. A) Representation of Clomeleon transfections in chick neural tube at E3 (stage 14–15 [12])
Figure 2. Clomeleon labeling in the chick spinal cord provides stable FRET ratios over time
Figure 3. Clomeleon measurements confirm high levels of Cl-in in spinal motoneurons. A) Scatter plot demonstrating the range of FRET ratios measured from motoneurons from 33 chick spinal cords (E10)
Figure 5. Gabazine is effectively washed out of the isolated spinal cord within minutes
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