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Explicit kinetic heterogeneity: mathematical models for interpretation of deuterium labeling of heterogeneous cell populations.

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Academic year: 2017

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Figure 1. A cartoon of the model with explicit kinetic heterogeneity. In the model, the population of cells consists of n sub-populations with different rates of turnover
Figure 2.Model predictions for exponentially distributed turnover rates. We have plotted the changes in the fraction of labeled DNA according to the explicit kinetic heterogeneity model with exponentially distributed turnover rates (eqn
Figure 4. Fits of artificial (simulated) data with various models. We have fitted artificial data (black dots) with the Asymptote model (eqn
Figure 6. Fits of the deuterium labeling data with mathematica models. Data on labeling of CD4 + (top rows) and CD8 + (bottom rows) T cells in four healthy humans were fitted by three models: the Asymptote model (panels A and D), the Exponential model, in
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