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Reduction of Adipose Tissue Mass by the Angiogenesis Inhibitor ALS-L1023 from Melissa officinalis.

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Fig 1. Inhibitory effects of ALS on angiogenesis and MMP activity. (A) Inhibition of VEGF-induced HUVEC proliferation by ALS
Fig 2. Regulation of body weight gain, adipose tissue mass and food consumption in high fat diet-fed obese mice
Fig 3. Light microscopy analysis of adipocyte size in adipose tissue. Adult male mice were fed a standard chow diet, a high fat diet, or the same high fat diet supplemented with 0.4 or 0.8% ALS for 8 weeks.
Fig 4. Histological analysis of blood vessels in adipose tissue stained with an antibody against vWF.
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