Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression.

Neste estudo evidencia-se a aplicação dessas ferramentas de pesquisa operacional, tal como a programação linear para modelagem e simulação da otimização do tempo

The probability of attending school four our group of interest in this region increased by 6.5 percentage points after the expansion of the Bolsa Família program in 2007 and

In this study after a single systemic LPS injection the expression of TNF- a in the serum preceded the up-regulation of IL-1 b (Figure 1B) suggesting that activation of the

Relative expression estimates for the target miRNAs (miRNA-21, miRNA-125b, miRNA-145, and miRNA-630) were obtained by image analysis of the ISH-stained slides ( Table 1 ).The

When EZH2 protein expression was significantly down-regulated by treatment with EZH2 siRNA the signal- ing proteins of the PI3K/Akt/mTOR pathway also showed a significant reduction

So, does this mean that if we block the activity of caspases we will prevent every sign of apoptosis and therefore keep the cells alive? The answer is yes in two situations: a)

In the present study, we demonstrated that Que postconditioning attenuates myocardial I/R injury in rats via activating the PI3K/Akt pathway and modulating Bcl-2 and Bax

These data show that fraction FA-2-b-ß can induce HL-60 cell apop- tosis and that the combined effect of down-regulation of telomerase activity and up-regulation of mRNA expression