ABSTRACT
ORIGINAL AR
TICLE
INTRODUCTION Sexual dysfunctions are represented by disturbancesrelatedtosexualdesireandpsy-cho-physiologicalchangesinthecycleofsexual response.Suchdysfunctionscausegreatsuffer-ing,aswellasinterpersonaldifficulties.1
About 30 million men in the United States present some erectile dysfunction thatcausessufferingandinterpersonaldif-ficulties.1-4AccordingtotheMassachusetts MaleAgingStudy(MMAS),552%ofmen between40and70yearsoldpresentsome type of erectile dysfunction. In a recent cross-national study published in 2003, 34%ofJapanesemen,22%ofMalaysians, 17%ofItaliansand15%ofBrazilianswere foundtopresentsomemoderatetosevere erectiledysfunction.6
Theinterestinsexualdysfunctionsthat hasarisenbothamonghealthprofessionals andamongthegeneralpublicispartlydue to increasing knowledge of the neurovas-cularmechanismsofthesexualresponsein menandwomen.7-9Severaltypesofdrugs have been developed for the treatment of erectile dysfunction, while other agents have been suggested for the treatment of inhibitionofsexualdesire.10-14However,few studiesontheoriginofthesedisturbances haveinvestigatedpsychosocialfactorssuch as unemployment.The increasing risk of erectile dysfunction has been correlated with diabetes, coronary heart disease and smoking.5,6,15-17Ariskoferectiledysfunction hasalsobeenfoundamongdepressedand unemployedmen.6,15,18-24
Inhibitionofsexualdesire,definedas theabsenceoforaseveredecreaseinfanta- siesanddesiresrelatedtoanysexualactiv-ity,isthemostfrequentsexualdysfunction among women.17,25-27 The prevalence of female inhibition of sexual desire ranges from5%to46%.25Nathan(1986)found
rates of 1% to 35% among women with complaints of inhibition of sexual desire in a literature review.28 Depression and age are the most common factors in the developmentofthisdysfunctioninwomen, asshowninseveralstudies.29-31
The present study shows the frequen-ciesofdepression,erectiledysfunctionand inhibition of sexual desire in a sample of the Brazilian population, with the aim of evaluating the risk of erectile difficulties andinhibitionofsexualdesireinrelation to depression, unemployment, aging and educationlevel.
METHODS TheBrazilianStudyofSexualBehavior (BSSB)wasconductedbetweenFebruary andApril2000,andwasperformedusing a non-random sample of 2,835 subjects (53% were women), from ten cities in seven Brazilian states.32 All subjects were aged 18 years or over. The sample was comparable to the general population of Brazil in terms of ethnicity and religion, but had a larger proportion of subjects withhighereducationlevels.33Thesubjects wereweekendvisitorstobeaches,parksand shoppingcenters,andtheywereinvitedto answer an anonymous self-administered questionnaire.
Theoriginalquestionnairewassubmitted toapilottest,inwhich30subjectsofboth sexes answered it. Following adjustments in terms of consistency and reliability, the final questionnaire included questions on demographicdata(e.g.age,employmentand educationlevel),generalhealth(self-reporting of medical conditions), lifestyle and sexual behavior.Thequestionnairehasalreadybeen publishedelsewhere.32
Withregardtotheerectiledysfunctionas-sessment,thesubjectswererequestedtochoose
CarmitaHelenaNajjarAbdo
WaldemarMendesde OliveiraJúnior
EdsonMoreiraJúnior
JoãoAfifAbdo
JoãoAntônioSaraivaFittipaldi
Theimpactofpsychosocialfactors
ontheriskoferectiledysfunction
andinhibitionofsexualdesireina
sampleoftheBrazilianpopulation
ProjectSexuality(ProSex),DepartmentandInstituteofPsychiatry,
MedicalSchooloftheUniversidadedeSãoPaulo,SãoPaulo,Brazil
CONTEXT:Sexualdysfunctionscanhaveorigins in physical, psychological and psychosocial factors.
OBJECTIVE:Todescribethefrequencyoferectile dysfunction(ED)andfemaleinhibitionofsexual desire(ISD)inaBraziliansample,andtoestimate therisksofthesedysfunctions.
TYPEOFSTUDY:Non-randomsurvey.
SETTING:TenBraziliancities.
METHODS:2,835subjects(53%women)aged over18yearsansweredaquestionnaireabout theirgeneralhealthandsexlife.Thechi-squared test and multivariate logistic regression were used. Values of p≤ 0.05 were considered significant.
RESULTS:Thewomen’saverageagewas36.6 years(±13.3)andthemen’swas39.5(±13.3). 14.7%ofmenpresentedmoderate/completeED and34.6%ofwomenpresentedISD.Depression wasmentionedby16.8%ofmenand29.7%of women.ThechancesofhavingEDandISDwere higherforsubjectswhohadhadlowerschool attainment.Lackofajobanddepressiongave riseto1.5times(95%CI:1.0–2.3)and1.9 times(95%CI:1.2–3.0)greaterchancesofED respectively.Comparedwithmenagedupto25 years,thoseaged41-60had1.9times(95%CI: 1.0–3.4)andthoseaged61andoverhad5.4 times(95%CI:2.3–12.6)greaterriskofED.For women,lackofajobgaveriseto1.5times(95% CI:1.1–1.9)greaterchanceofISD;depression wasnotassociatedwithhigherrisk.Compared withwomenagedupto25years,thoseaged 41-60 and 61 or over had, respectively, 2.9 times(95%CI:2.0–4.1)and7.5times(95% CI:3.0–18.6)greaterriskofISD.
DISCUSSION: Increasing unemployment has affected the whole population, but especially those with lower levels of school attainment. Suchlevelsarepositivelylinkedwithpresence ofsexualdysfunctions.
CONCLUSION:Lackofjobs,ageandlowschool attainmentarerisksforthesexualdysfunctions studied.DepressionincreasedtheriskofEDbut notfemaleISD.
KEYWORDS:Impotence.Depression.Education. Unemployment.
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onecategorythatbestdescribedthem:always, usually, sometimes, or never able to achieve andmaintainanerectionthatwassatisfactory forsexualperformance.Theanswerswerethen usedtoclassifytherespondentsintooneofthe followingcategories:none,minimal,moderate, orcompleteerectiledysfunction,respectively.
Fortheassessmentofinhibitionofsexual desireanddepression,subjectswereaskedto markwithan“X”,besidetherespectivequestion, iftherehadbeensomeinhibitionorabsenceof sexualdesireordepressionduringtheirlives.
The chi-squared test and multivariate logistic regression were used for statistical analysis.Valuesofp≤0.05wereconsidered statisticallysignificant.
Notallthemenorwomenansweredall theitemsofthequestionnaire.Consequently, inpresentingthevariablestudied,thenumber of subjects who answered this question has beenspecified.Therewerenodifferencesbe-tweensubjectswhoansweredthesequestions andthosewhodidnot.
For the multivariate logistic models, therewere1,257womenand1,057men. Onlythevariablesthatwerepartofthemain objectiveofthepresentstudy(age,educa-tionlevel,unemploymentanddepression) havebeenincluded.Menandwomenwho did not answer at least one of the ques-tionsonage,educationlevel,depressionor employmenthavebeenexcludedfromthis study.Nostatisticallysignificantdifference was presented between those who were excludedandthoseincluded,inrelationto thevariablesstudied.
RESULTS Theaverageagewas36.6years(standard deviation,SD=13.3)forwomenand39.5 years(SD=13.3)formen.
41%ofthewomenand22.5%ofthemen who answered the question about working conditionwereunemployed.Depressionwas mentionedby29.7%ofthewomenand16.8% ofthemenwhoansweredthisquestions.
Table1.Proportion(%)ofdepressionandsexualdysfunctions(inhibitionofsexual desireinwomenormoderate/completeerectiledysfunctioninmen)accordingto ageandworkingstatusandeducationattainmentbygender
Women Men
Total ISDn(%) Total EDn(%)
Age(years)
Upto25 384 90(23.4) 190 19(10.0) 26to40 561 145(25.8) 493 47(9.5) 41to60 455 214(47.0) 395 71(18.0) >60 74 54(73.0) 83 32(38.6) pfortrend <0.01 <0.01
Women Men
Depn(%) ISDn(%) Depn(%) EDn(%)
Workingstatus
Unemployed 175/526
(33.3%) 189/526(35.9%) 55/263(20.9%) 43/240(17.9%) Employed 202/757
(26.7%) 205/757(27.1%) 146/905(16.1%) 93/822(11.3%) pfortrend 0.011 0.001 0.07 0.007
Women Men
n(%) n(%)
Educationalattainment(years)
Lessthaneight 118(8.0) 93(7.3) Eight 156(10.6) 138(10.8) Eleven 604(41.1) 537(41.9) Morethaneleven 591(40.2) 514(40.1) pforgender 0.884
ISD=inhibitionofsexualdesire;ED=erectiledysfunction;Dep=depression.
Thetotalfrequencyoffeminineinhibition ofsexualdesirewas34.6%ofrespondents.For men,14.7%hadmoderatetosevereerectile dysfunction.
We observed that unemployed women and men presented higher frequencies of depression, as well as higher frequencies of inhibition of sexual desire and erectile dys-function,respectively(Table1).
Botherectiledysfunctionandinhibition ofsexualdesirearedirectlyrelatedtoaging. AsTable1shows,thereisatendencytowards higher frequencies of these dysfunctions amongoldersubjects.
The results from the multivariate lo-gistic regression model showed that, for women, being unemployed, getting older and having less than 11 years of school education increased the chance of inhibi-tionofsexualdesire(Table2).Depression did not increase the chance of inhibition of sexual desire and was not included in thefinalmodel.
Unemployment,aging,lessthan11years ofschooleducationanddepressionincreased thechanceofmoderatetosevereerectiledys-functionamongmen(Table2).
DISCUSSION The frequencies of erectile dysfunction andinhibitionofsexualdesireinoursample werehigh.
Inthemedicalliterature,differentpreva-lencesofsexualdysfunctionsarefound.This variationisduepartlytothetypeofsample studied(communityversussexualityclinics), thetypeoftrialperformed(self-administered questionnairesorinterview),andtheclinical definitionusedforeachdysfunction.25
Thepresentstudydoesnotrepresenta sampleofallsocioeconomic-culturalclasses oftheBrazilianpopulation,butitcangive usanideaofhowprevalentsexualdysfunc-tions are. It can serve as a starting-point for future surveys with a wider-ranging sample of people and also for pointing out possible associations between sexual dysfunctions and depression and other sociodemographicfactors.
The same tendency towards increas-ing erectile dysfunction and inhibition of sexual desire with age that was noticed in previous studies was found in the present sample.3,6,15,17,24
Severalstudieshaveindicatedarelation-shipbetweendepressivesymptomsanderectile dysfunction.Theseconditionsarecommonly associated,mutuallymaintainingorenhanc-ingeachother.34-37
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UrolClinNorthAm.1995;22(4):699-709.
3. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol.1994;151(1):54-61.
4. McDonaghR,EwingsP,PorterT.Theeffectoferectiledysfunc-tiononqualityoflife:psychometrictestingofanewquality oflifemeasureforpatientswitherectiledysfunction.JUrol. 2002;167(1):212-7.
5. AraujoAB,DuranteR,FeldmanHA,GoldsteinI,McKinlayJB. Therelationshipbetweendepressivesymptomsandmaleerectile dysfunction:cross-sectionalresultsfromtheMassachusettsMale AgingStudy.PsychosomMed.1998;60(4):458-65. 6. NicolosiA,MoreiraED,ShiraiM,BinMohdTambiMI,Glasser
DB. Epidemiology of erectile dysfunction in four countries: cross-nationalstudyoftheprevalenceandcorrelatesoferectile dysfunction.Urology.2003;61(1):201-6.
7. RajferJ,AronsonWJ,BushPA,DoreyFJ,IgnarroLJ.Nitric oxideasamediatorofrelaxationofthecorpuscavernosumin responsetononadrenergic,noncholinergicneurotransmission. NEnglJMed.1992;326(2):90-4.
8. BurnettAL.Roleofnitricoxideinthephysiologyoferection. BiolReprod.1995;52(3):485-9.
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12. MoralesA,HeatonJP,JohnstonB,AdamsM.Oralandtopical treatmentoferectiledysfunction.Presentandfuture.UrolClin NorthAm.1995;22(4):879-86.
13. RosenRC,AshtonAK.Prosexualdrugs:empiricalstatusofthe “newaphrodisiacs”.ArchSexBehav.1993;22(6):521-43. 14. SegravesRT,CroftH,KavoussiR,etal.Bupropionsustainedrelease
(SR)forthetreatmentofhypoactivesexualdesiredisorder(HSDD) innondepressedwomen.JSexMaritalTher.2001;27(3):303-16.
15. AkkusE,KadiogluA,EsenA,etal.Prevalenceandcorrelates oferectiledysfunctioninTurkey:apopulation-basedstudy.Eur Urol.2002;41(3):298-304.
16. MoreiraED,LisboaLôboCF,VillaM,NicolosiA,GlasserDB. PrevalenceandcorrelatesoferectiledysfunctioninSalvador, northeasternBrazil:apopulation-basedstudy.IntJImpotRes. 2002;14(Suppl2):S3-9.
17. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA. 1999;281(6):537-44.
18. MayJL,BobeleM.Sexualdysfunctionandtheunemployed maleprofessional.JSexMaritalTher.1988;14(4):253-62. 19. MorokoffPJ,BaumA,McKinnonWR,GillillandR.Effectsof
chronicunemploymentandacutepsychologicalstressonsexual arousalinmen.HealthPsychol.1987;6(6):545-60. 20. MeislerAW,CareyMP.Depressedaffectandmalesexualarousal.
ArchSexBehav.1991;20(6):541-54.
21. KantorJ,BilkerWB,GlasserDB,MargolisDJ.Prevalenceoferectile dysfunctionandactivedepression:ananalyticcross-sectionalstudyof generalmedicalpatients.AmJEpidemiol.2002;156(11):1035-42. 22. NurnbergHG,SeidmanSN,GelenbergAJ,FavaM,RosenR,Shab-sighR.Depression,antidepressanttherapies,anderectiledysfunction: clinicaltrialsofsildenafilcitrate(Viagra)intreatedanduntreated patientswithdepression.Urology.2002;60(2Suppl2):58-66.
Table2.Oddsratiosand95%confidenceinterval(CI)forfemaleinhibitionofsexual desire(n=1,257)anderectiledysfunction(n=1,057),accordingtoage,social-demographiccharacteristicsanddepression*
Femaleinhibitionofsexualdesire Erectiledysfunction
Variable Oddsratio(95%CI) Oddsratio(95%CI)
Age(years)
Upto25 26-40 41-60 >60
1.0(reference) 1.1(0.8–1.6) 2.9(2.0–4.1) 7.5(3.0–18.6)
1.0(reference) 0.9(0.5–1.7) 1.9(1.0–3.4) 5.4(2.3–12.6)
Educationalattainment(years)
Morethaneleven Elevenyears Eightyears Lessthaneight
1.0(reference) 1.3(1.0–1.8) 2.4(1.5–3.7) 1.8(1.1–3.0)
1.0(reference) 1.8(1.1–2.8) 2.8(1.5–5.3) 4.4(2.2–8.7)
Workingstatus
Employed Unemployed
1.0(reference) 1.5(1.1–1.9)
1.0(reference) 1.5(1.0–2.3)
Depression
No Yes
1.0(reference) 1.9(1.2–3.0)
*DataobtainedfromtheBrazilianStudyofSexualBehavior.Resultsderivedfrommultivariatelogisticregression.
The trend towards increasing unem-ploymentaroundtheworld18hasaffectedall levelsofthepopulation,especiallyinBrazil. Ithasparticularlyaffectedthosewithlower levels of school attainment. On the other hand, lower levels of education are also positivelylinkedwiththepresenceofsexual dysfunctionsinthepresentsample,inthe samewayasfoundbyLaumann,Paikand Rosen (1999).17In our sample, these two factorsworkedindependentlytoincreasethe chancesofhavingthesexualdysfunctions studied.Therefore,thehigherriskofsexual dysfunction among unemployed subjects cannot be explained by the low level of schoolattainmentalone.
CONCLUSIONS Age, unemployment and low levels of schoolattainmentincreasedtheriskofinhibi- tionofsexualdesireamongwomenanderec-tiledysfunctionamongmenindependentlyof eachother,inthepresentsample.
Depressionincreasedtheriskoferectile dysfunction, but not female inhibition of sexualdesire,whichsuggestsaneedfornew investigationandanalysis.
The results from this study show that, forcorrectdiagnosisandsuccessfultreatment ofthesedysfunctions,emotionalfactors(de-pression)andsocioeconomic-culturalfactors mustbeassessedalongsidephysicalfactors.
Older patients’ own characteristics should also be taken into consideration, since the older the subjects are, the more prevalent thesedysfunctionsare.
Thisstudyhasconfirmedthestrongas- sociationbetweensexualdysfunctions,depres-sionandpoorsocioeconomicconditionssuch asunemploymentandloweducationallevel.
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RitterJS.Increasedincidenceofdepressivesymptomsinmen witherectiledysfunction.Urology.1998;52(5):848-52 35.
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HartmannU.PsychischeBelastungsfaktorenbeierektilenDys-funktionen.VerursachungsmodelleundempirischeErgebnisse [Psychological stress factors in erectile dysfunctions. Causal modelsandempiricalresults].UrologeA.1998;37(5):487-94.
Sourcesoffunding:FinancialsupportfromPfizer Laboratories
Conflictofinterest:Dr.FittipaldiisMedicalDirectorofthe BrazilianbranchofPfizerInc.,manufacturerofViagra®
Dateoffirstsubmission:November10,2003
Lastreceived:December2,2004
Accepted:December8,2004
RESUMO Impactodosfatorespsicossociaisparariscodedisfunçãoerétileinibiçãododesejosexual,numaamostra dapopulaçãobrasileira
CONTEXTO:Asdisfunçõessexuaisoriginam-sedefatoresfísicos,psicológicosepsicossociais.
OBJETIVO:Apresentarfreqüênciasdedisfunçãoerétileinibiçãododesejosexualfemininoemamostra brasileiraeestimarriscosdestasdisfunções.
TIPODOESTUDO:Transversal.
LOCAL:10cidadesbrasileiras.
MÉTODOS:2.835indivíduos(53%mulheres),maioresde18anos,responderamaumquestionáriosobre saúdegeralevidasexual.Foramutilizadostestesdequi-quadradoeregressãologísticamultivariada.São significantesvaloresdep≤0.05.
RESULTADOS:Aidademédiafoi36,6anos(DP=13,3)paramulherese39,5anos(DP=13,3)para homens.14,7%doshomensapresentavamdisfunçãoerétilmoderada/completa(DE)e34,6%dasmulheres, inibiçãododesejosexual(IDS).Depressãofoireferidapor16,8%doshomense29,7%dasmulheres.A chanceparaDEeIDSfoimaiorparaindivíduoscommenosanosdeescolaridade.Faltadeempregoe depressãoaumentaram1,5vezes(95%CI;1,0–2,3)e1,9vezes(95%CI;1,2–3,0)aschancespara DE,respectivamente.Comparadosaoshomenscomaté25anosdeidade,aquelescom41a60anos tiveramrisco1,9vezesmaiorparaDE(95%CI;1,0–3,4)e5,4vezes(95%CI;2,3–12,6)paraaqueles com61anosoumais.Paramulheres,afaltadeempregoaumentou1,5vezesachanceparaIDS(95% CI;1,1–1,9);adepressãonãoaumentouorisco.Comparadasàsmulherescomaté25anos,aquelas com41a60anosecom61anosoumaistêmrisco2,9vezesmaiorparaIDS(95%CI;2,0–4,1)e7,5 vezesmaior(95%CI;3,0–18,6),respectivamente.
DISCUSSÃO:Odesemprego,comotendênciamundialcrescente,temafetadotodososníveisdapopulação, especialmenteoscombaixoníveldeescolaridade.Baixosníveisdeescolaridadeestãocorrelacionados positivamenteàpresençadedisfunçõessexuais.
CONCLUSÕES:Ausênciadeemprego,idadeebaixaescolaridaderepresentamriscoparaasdisfunções sexuaispesquisadas.Depressãoaumentouoriscoparadisfunçãoerétil,masnãoparainibiçãododesejo sexualfeminino.
PALAVRAS-CHAVE:Impotência.Depressão.Educação.Desemprego.
AUTHORS INFORMATION CarmitaHelenaNajjarAbdo,PhD. AssociateProfessor,De-partmentofPsychiatry,MedicalSchooloftheUniversidade deSãoPaulo.CoordinatorofProjectSexuality(ProSex), InstituteofPsychiatry,MedicalSchooloftheUniversidade deSãoPaulo,SãoPaulo,Brazil.
WaldemarMendesdeOliveiraJúnior,MD.AssistantPhysician, InstituteofPsychiatry,MedicalSchooloftheUniversidade deSãoPaulo,SãoPaulo,Brazil.
EdsonMoreiraJúnior,MD.AssociateResearcher,Oswaldo CruzFoundationandInstitute.CoordinatorofEpidemiology andStatisticsNucleus,GonçaloMunizResearchCenter, Bahia,Brazil.
João Afif Abdo, MD. Medical Doctor, Urologist, Hospital SantaCruz,SãoPaulo,Brazil.
JoãoAntônioSaraivaFittipaldi,MD.MedicalManagerof PfizerLaboratories,SãoPaulo,Brazil.
Addressforcorrespondence: CarmitaHelenaNajjarAbdo
R.GilEanes,492
SãoPaulo(SP)—Brasil—CEP04601-041 Tel.(+5511)5092-5345-Fax(+5511)5543-8338 E-mail:carmita.abdo@uol.com.br
Copyright©2005,AssociaçãoPaulistadeMedicina