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Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing.

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Figure 1. Interaction of RED with influenza virus polymerase in human cells. A. Schematic representation of the Gaussia princeps luciferase- luciferase-based complementation assay and Normalized Luminescence Ratios (NLRs) calculation method
Figure 2. Mapping of the interaction domain of RED with the viral polymerase. A. Schematic representation of the full-length RED, N- N-terminal domain (Nt-RED) and C-N-terminal domain (Ct-RED) of RED that were transiently expressed in the experiment shown
Figure 5. Effect of RED or SMU1 knock-down on influenza virus multicycle growth. A. A549 cells were transfected with control non-target siRNAs (NT), a pool of four RED siRNAs (Rp), individual RED siRNAs (R1, R2), or a pool of four SMU1 siRNAs (Sp)
Figure 6. Effect of RED or SMU1 knock-down on the accumulation of influenza virus mRNAs
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