Alternative splicing
Epigenetics and alternative splicing
... isoforms. Alternative splicing and editing contribute to the increasing gene isoform diversity (Geisler & Coller ...influence splicing patterns of ...the splicing of ZEB2 (zinc- finger ...
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Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.
... of alternative splicing (Fig ...and splicing fac- tors, the widespread changes in RNA splicing, and the enriched MeCP2 occupancy around exon/intron boundary are consistent with each other and ...
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Eye development under the control of SRp55/B52-mediated alternative splicing of eyeless.
... Exon2 of eyeless contains B52 binding sequences To further confirm the involvement of B52 in regulating eyeless alternative splicing, we employed RNA interference in Drosophila SL2 cells. We observed that ...
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Fine-scale variation and genetic determinants of alternative splicing across individuals.
... 70 alternative splicing events, and showed that 6 of them were consistently associated with a specific ...of alternative splicing events may be controlled by genetic ...
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Width of gene expression profile drives alternative splicing.
... that alternative splicing variants of widely expressed genes could be easier to detect (see ...less alternative spliced forms than those of the rest of the genome irrespective of their breadth of ...
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Alternative splicing detection across different tissues in cork oak
... joined. Alternative splicing (AS) of precursor mRNA is a molecular phenomenon found in eukaryotic species that may generate different mature mRNAs (isoforms) based on the differential use of splice sites ...
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MiasDB: A Database of Molecular Interactions Associated with Alternative Splicing of Human Pre-mRNAs.
... with alternative splicing (MiasDB) ...TFs, splicing-associated kinases and modified histones for 173 human AS ...between splicing factors and other signal path- ways, and as a proof of ...
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An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.
... epithelial-specific splicing of a number of genes, some of which have well documented and essential roles in EMT ...mesenchymal splicing program to an epithelial state and allow us to examine the role of ...
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Analysis of the contribution of alternative splicing to glioma subtype definition
... namely splicing factor genes, and alternative splicing events associated with LGm ...237 alternative splicing events that showed to add prognostic value to the above-mentioned model ...
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Alternative splicing originates different domain structure organization of Lutzomyia longipalpis chitinases
... larval alternative splicing forms a differen- tial translation process occurs, through the introduction of an alternative stop codon ...of alternative processing with the introduction of stop ...
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Identification of rare alternative splicing events in MS/MS data reveals a significant fraction of alternative translation initiation sites
... query alternative splicing events and their specific data, such as predicted ...showing alternative splicing events supported only by ESTs and/or RNASeq expressed sequences were ...combined ...
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A Computational Platform for Assessing the Impact of Alternative Splicing in Cancer
... aberrant alternative splicing in the development of ...aberrant alternative splicing in mind) the possibility to search for information on available databases on the internet in a user ...
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Alternative splicing and SR proteins in ABA-mediated stress responses
... temperature stress lead to reduced water availability (also known as osmotic stress), characterized by a decreased turgor pressure and water loss. Osmotic stress promotes the synthesis of the plant stress hormone ...
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A statistical method for the detection of alternative splicing using RNA-seq.
... Several methods have been applied to detect AS events. Expression Sequence Tag (EST) was the first widely used technology and played a leading role in detecting AS events. However, except for the relatively high cost, ...
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A functional alternative splicing mutation in AIRE gene causes autoimmune polyendocrine syndrome type 1.
... Figure 2. Alternative splicing of AIRE by the c.463G.A mutation. (A) Schematic diagram of the AIRE minigene constructs. Complete genomic DNA spanning from exon 2 to exon 5 of AIRE gene was amplified from ...
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Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells.
... Alternative splicing involves differential exon selection of a gene transcript to generate mRNA and protein isoforms with structural and functional ...Abnormal alternative splicing has been ...
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Single molecule analysis of c-myb alternative splicing reveals novel classifiers for precursor B-ALL.
... both alternative exons 9B and 10A, was detected in both K562 ...an alternative exon 10A, was detectable in Jurkat ...of alternative exons 8A, 9A, 9B and 10A that were similar to the Figure ...1. ...
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Strategies for identifying RNA splicing regulatory motifs and predicting alternative splicing events.
... of Alternative Splicing The principal computational approach to identifying AS genes, and to infer individual alternative exon events or complete alternative isoform structures, relies on the ...
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Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.
... whether splicing abnormalities had preceded the onset of symptoms, as would be predicted from the crucial role of SMN in spliceosome assembly, particularly in embryonic and early post- natal development ...
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Expression analysis of an evolutionarily conserved alternative splicing factor, Sfrs10, in age-related macular degeneration.
... with alternative splicing mediated gene regulation is not well ...explored. Alternative Splicing is one of the primary mechanisms in humans by which fewer protein coding genes are able to ...
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