alternative splicing events
Identification of rare alternative splicing events in MS/MS data reveals a significant fraction of alternative translation initiation sites
... of splicing variants recently developed by us, to search MS data derived from a variety of human tumor cell ...of splicing variants (exon skipping, alternative splice sites and intron reten- tion) ...
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Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.
... that alternative splicing events are a consequence of disease progression in SMA, rather than the primary ...the splicing index method is known to lead to inaccuracies if complex ...
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Global profiling of alternative splicing events and gene expression regulated by hnRNPH/F.
... 4B). Splicing of a constitutive exon is differentially regulated by depletion of hnRNPH/F along with changes in expression of cdk2, SOX6 and hnRNPA2/B1, suggesting that an effect in splicing may be coupled ...
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A general definition and nomenclature for alternative splicing events.
... AS events in protein coding regions ...AS events in 59 UTRs (Figure 4), not biased by the difference in size between the datasets (Figure ...AS events observed in noncoding transcripts correspond to ...
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Strategies for identifying RNA splicing regulatory motifs and predicting alternative splicing events.
... Computational challenges. As experimental systems and models for the regulation of AS have been steadily validated and refined, so have bioinformatics tools and computational models [15,16]. With the availability of ...
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Splicing Express: a software suite for alternative splicing analysis using next-generation sequencing data
... ). Splicing Express, moreover, uses an strategy implemented previously by us in Splooce ( Kroll et ...their splicing differences. Currently, Splicing Express is able to identify patterns of simple ...
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Analysis of the contribution of alternative splicing to glioma subtype definition
... namely splicing factor genes, and alternative splicing events associated with LGm ...237 alternative splicing events that showed to add prognostic value to the ...
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Single molecule analysis of c-myb alternative splicing reveals novel classifiers for precursor B-ALL.
... c-myb alternative splicing, we detected much more complex and combinatorial alternative splicing events than could be monitored using microarray or QPCR ...c-myb alternative ...
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Assessing the impact of alternative splicing in thyroid cancer
... on alternative splicing events between two samples as this is the only number of samples allowed for a MATS ...the alternative splicing analysis is also, necessarily, unstranded, which ...
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A statistical method for the detection of alternative splicing using RNA-seq.
... Several methods have been applied to detect AS events. Expression Sequence Tag (EST) was the first widely used technology and played a leading role in detecting AS events. However, except for the relatively ...
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Fine-scale variation and genetic determinants of alternative splicing across individuals.
... such events in lymphoblastoid cell lines [7]. They selected 70 alternative splicing events, and showed that 6 of them were consistently associated with a specific ...of alternative ...
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When chromatin structure meets CD6 exon 5 Alternative Splicing: an encounter triggered by T cell activation
... in alternative splicing regulation is through an adapter system that can recruit splicing factors during ...PTB-dependent alternative splicing events ...(PTB) splicing ...
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Genome-wide analysis of alternative splicing during dendritic cell response to a bacterial challenge.
... of alternative splicing in the context of an immune response, there are no previous reports focusing on dendritic cells in response to an immune ...tive splicing in the immunobiology of DCs, we used ...
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An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.
... altered splicing during EMT showed strong enrichment for involvement in biological processes related to the regulation of the actin cytoskeleton, cell-cell junctions, regulation Figure ...1. Alternative ...
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Differential HFE Gene Expression is Regulated by Alternative Splicing in Human Tissues
... Figure 1. Splicing forms of HFE gene in several human tissues. (A) Schematic representation of the HFE immature protein. The distinct patterns depict HFE protein domains: the signal peptide (signal), the three ...
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A functional alternative splicing mutation in AIRE gene causes autoimmune polyendocrine syndrome type 1.
... Minigene splicing analysis and subsequent cDNA sequencing revealed that the AIRE mutation potentially compromised the recognition of the splice donor of intron 3, causing alternative pre-mRNA ...
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Alternative splicing of tumour-related Rac1b is regulated by upstream signalling pathways
... The levels of ASF/SF2 and SRp20 transcript and protein correlate with Rac1b expression in colorectal cells. PI3-kinase and Wnt signalling pathways synchronize the expression of ASF/S[r] ...
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Reciprocal regulation between alternative splicing and the DNA damage response
... different splicing variants of BRCA1, a well know cancer susceptibility gene, modulate DNA repair mechanisms (Sevcik et ...the splicing process, af- fecting the expression of repair factors (Savage and ...
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Alternative splicing originates different domain structure organization of Lutzomyia longipalpis chitinases
... of alternative splic- ing. The transcription of the alternative splicing forms is reduced when L4 larvae stop eating during preparation for pupation at pre-pupae stage ...
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Bioinformatics application for analysis and visualisation of alternative splicing in cancer
... Many packages extend ggplot2’s functionality and such is the case with ggiraph and ggvis, that include contextual tooltips and support JavaScript click events on data points but are limited to few types of plots. ...
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