Antifungal drug
A case for two-component signaling systems as antifungal drug targets.
... part due to the relative evolutionary relatedness of fungi and mammals and the resulting pauci- ty of fungal-specific proteins that meet these criteria. One class of molecules that do fit both of these criteria is ...
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Environmental isolation, biochemical identification, and antifungal drug susceptibility of Cryptococcus species
... the antifungal drugs amphotericin B, itraconazole (Jansen Pharmaceuticals, Beerse, Belgium), voriconazole, and fluconazole (Pfizer International, New York, NY) were tested against all of the ...cations. ...
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Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia
... 18. Marco, F., C. Danes, M. Almela, A. Jurado, J. Mensa, J. P. de la Bellacasa, M. Espasa, J. A. Martinez, and M. T. Jimenez de Anta. 2003. Trends in frequency and in vitro susceptibilities to antifungal agents, ...
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Yeasts acquire resistance secondary to antifungal drug treatment by adaptive mutagenesis.
... a drug that has a completely different mode of action, ...either drug takes place in vitro and we show how this acquisition fulfills the previously described requirements for an adaptive mutagenesis model ...
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Invasive candidosis: contrasting the perceptions of infectious disease physicians and intensive care physicians
... Nearly (96.4%) all participants expressed concerns regarding fl uconazole use in patients with invasive Candida infections. However, fl uconazole was the preferred antifungal drug for 91.1% of the interviewed ...
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Candida albicans Targets a Lipid Raft/Dectin-1 Platform to Enter Human Monocytes and Induce Antigen Specific T Cell Responses.
... cholesterol-binding antifungal drug Ampho- tericin B strongly impairs the uptake of the fungal pathogen Candida albicans by human monocytes, suggesting a role of raft microdomains in the phagocytosis of the ...
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Antifungal susceptibility profiles of 1698 yeast reference strains revealing potential emerging human pathogens.
... pathogens. Antifungal susceptibility provides important information for ecological, epidemiological and therapeutic ...their antifungal drug resistance, keeping in mind the methodological ...
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Carum copticum and Thymus vulgaris oils inhibit virulence in Trichophyton rubrum and Aspergillus spp
... spectrum antifungal compounds from natural products including me- dicinal plants which can be used alone or in combiantion with known antifungal ...of drug resistance (Baddley and Pappas, ...novel ...
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Simvastatin inhibits planktonic cells and biofilms of Candida and Cryptococcus species
... There is no synergistic interaction when simvastatin is associated with amphotericin B against most Candida spp. strains. Statins reduce the amount of fungal ergosterol, which may lead to decreased activity of ...
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SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
... Previously, the fungal phosphatidylserine (PS) synthase (Cho1p) was identified as a promis- ing antifungal drug target for several reasons. First, Cho1p has been demonstrated to be required for Candida ...
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Antifungal activity of Terminalia superba (combretaceae)
... addition all the 6 extracts of T. superba exerted a very high level of antifungal activity. These obtained data highlighted the significant antifungal potency of extract from T. superba. The elucidation of ...
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Rev. bras. farmacogn. vol.20 número3
... We present here the antifungal properties of the different extracts, fractions and ellagic acid of L. pacari. At irst, we tested them using the microbroth dilution method against a panel of standardized yeasts, ...
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Open Avaliação das atividades antifúngica, antioxidante e citotóxica dos monoterpenos (r)(+)citronelal, (s)()citronelal, 7
... of drug-resistant fungi is one of the most serious threats to the successful treatment of fungal diseases, in addition, some drugs are very toxic, hindering adherence to ...the antifungal, cytotoxic and ...
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Braz. J. Pharm. Sci. vol.47 número1
... the antifungal activity of the Cymbopogon winterianus essential oil against ...The antifungal tests consisted of antifungal screening, determination of MIC and MFC, analysis of the essential oil’s ...
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Effect of farnesol on growth, ergosterol biosynthesis, and cell permeability in Coccidioides posadasii
... Inhibitory effect of farnesol in the presence of osmotic stress. The ability of farnesol to alter the permeability of the fungal membrane was also evaluated by macrodilution. To induce osmotic stress, we used the method ...
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Synthesis, characterization and antifungal activity of quaternary derivatives of chitosan on Aspergillus flavus
... Although increasing concentrations of chitosan may improve the inhibition percentage on many pathogens this trend depends on several factors such as molecular weight of chitosan, targeted pathogen and pH (Yang et al. ...
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Braz. J. Pharm. Sci. vol.53 número2
... potential drug targets that utilises a large-scale reverse pharmacophore mapping strategy (Liu et ...potential drug target databases, and includes over 7000 receptor-based pharmacophore models (Liu et ...
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CD34.R14: The fight against drug addiction, drug abuse, and drug trafficking
... Having seen the resolution of the Special Meeting of Ministers of Health of the Andean Area; Considering Resolution XVIII of the XXXIII Meeting of the Directing Council in which the Member Countries are urged to support ...
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Antifungal Activity of Maytenin and Pristimerin
... Two pure substances extracted from Maytenus ilicifo- lia, maytenin and pristimerin, were prepared as described byScorzoni et al. 2007 [10]. The antifungal drugs were diluted according to CLSI M27-S3 [9]. Inoculums ...
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Antifungal compounds as a mechanism to control Hemileia
... with antifungal action produced by the antagonist bacteria was/were responsible to disease control, and there was a direct effect between the antagonist concentrations and the disease ...
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