BETA-CELL
Fetal and neonatal nicotine exposure in Wistar rats causes progressive pancreatic mitochondrial damage and beta cell dysfunction.
... altered beta cell ...within beta cells of nicotine- exposed ...of beta cell ...per beta cell area of: A) total insulin granules (filled, immature and empty); B) immature ...
10
Chaperones ameliorate beta cell dysfunction associated with human islet amyloid polypeptide overexpression.
... stress-mediated apoptosis, leading to a reduction in beta-cell mass [29]. These differences can be explained by the different levels of hIAPP expression or the use of different experimental models, such as ...
11
Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.
... The antiapoptotic Bcl-2 protein Mcl-1 is an important regulator of beta cell death after exposure to proinflammatory cytokines and ER stressors [20]. Mcl-1 protein expression gradually decreased from 6h ...
15
Sustained beta-cell dysfunction but normalized islet mass in aged thrombospondin-1 deficient mice.
... each beta-cell is surrounded by at least one islet endothelial cell, and therefore these cells by necessity are exposed to each other’s products ...the beta-cells ...adult ...
7
Enhancing pancreatic Beta-cell regeneration in vivo with pioglitazone and alogliptin.
... that beta-cell regeneration in STZ- diabetic mice can occur when normoglycemia is maintained by insulin implants or islet transplantation ...of beta-cell regeneration in living mice, and to ...
8
Vildagliptin Ameliorates Oxidative Stress and Pancreatic Beta Cell Destruction in Type 1 Diabetic Rats
... Recent studies in rodent models of diabetes suggest that DPP-IVi have the ability to increase islet mass and preserve b-cell function by immediate reactivation of b-cell glucose competence as well as ...
9
Non-obese adult onset diabetes with oral hypoglycemic agent failure: islet cell autoantibodies or reversible beta cell refractoriness?
... Beta cell function and insulin sensitivity before and after a period of insulin therapy were also compared by HOMA in the two groups of OHAF diabetic patients (autoanti- body-positive and ...
9
Beta cell 5'-shifted isomiRs are candidate regulatory hubs in type 2 diabetes.
... pancreatic beta cell ...human beta cell miRNAs, including 5 9-shifted isomiRs, serve as regulatory hubs in ...in beta cell function and glucose homeostasis ...the beta ...
9
Topologically heterogeneous beta cell adaptation in response to high-fat diet in mice.
... in beta cell ...that beta cell mass adaptation is regulated by neuronal signals from the liver ...increased beta cell function and proliferation ...increased beta ...
8
Tissue-specific methylation of human insulin gene and PCR assay for monitoring beta cell death.
... circulating beta cell DNA in streptozotocin-treated mice prior to the rise in blood ...that beta cell death occurs six weeks before the rise in blood sugar and coincides with the onset of ...
9
IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes.
... insulin-producing beta cells, resulting in dependence on exogenous ...T cell expansion and ...T cell function allows for reversal of diabetes after onset is not clearly ...increase beta ...
12
Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose.
... Proper function of the lysosomal compartment is crucial to preserve cellular homeostasis. In early endosomes, pro-cathepsins are cleaved into active cathepsins. This maturation of ca- thepsins by autocatalysis or by ...
18
Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1
... he prevalence of type 2 diabetes is continuously increasing and this results in serious health problems. Both decreased β-cell function and increased insulin resistance contribute to the onset of type 2 diabetes. ...
5
The Beta Cell in Its Cluster: Stochastic Graphs of Beta Cell Connectivity in the Islets of Langerhans.
... We propose that graph theory is an appropriate framework for quantifying β-cell arrange- ment because it captures quantitative aspects of connectivity flexibly. Graph theory has been used in many contexts in ...
29
Perfil glicometabólico inicial em pacientes com síndrome coronariana aguda e síndrome metabólica
... Figure 1 - A - Box-plots showing the homeostasis model assessment (HOMA-IR) values obtained for subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), or diabetes (DM). Based on the HOMA-IR, ...
5
Arq Bras Endocrinol Metab vol.52 número2
... muscular cell line; inhibition of SP1 activity by NO may thus contribute for the observed decrease in SERCA2 mRNA expres- sion ...in beta- cells seems to be defective for the activation of the ATF-6 branch ...
10
Helicobacter pylori seropositivity and risk of lung cancer.
... Lung cancer kills more people worldwide (over 1 million each year) than any other cancer [1]. Although smoking is the primary cause, most smokers ($80%) never develop lung cancer [2], suggesting that oncogenesis requires ...
6
Rev. Bras. Hematol. Hemoter. vol.38 número4
... of beta-thalassemia (beta- thalassemia intermedia), in which mutations of both beta genes occur (a mild mutation in one and a severe mutation in the other, or two mild mutations or a complex muta- ...
5
Suppression of tumorigenicity and metastatic potential of melanoma cells by transduction of interferon gene
... Proliferative potential and synthesis of recombinant murine IFN-beta of melanoma cells transduced with rBV and rBV/IFN were determined by immunocytochemical evaluation of the cells expressing Ki-67 protein (marker ...
7
Rev. Bras. Hematol. Hemoter. vol.35 número3
... sickle cell patients, including the excessive levels of cell-free hemoglobin with its catalytic action on oxidative reactions, characteristic recurrent ischemia-reperfusion events, a chronic pro- ...
3