cardiac hypertrophy
Global microRNA profiles and signaling pathways in the development of cardiac hypertrophy
... of hypertrophy, many of which have not been reported ...of hypertrophy, which highlight the potential of miRNAs as targets for development of diagnostic and prognostic biomarkers and/or for therapeutic ...
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Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants
... with cardiac-specific expression of activated Akt have demon- strated that chronic Akt activation has detrimental effects after ischemia/reperfusion injury, due to feedback inhibition of phosphoinositide 3-kinase ...
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Adiponectin Upregulates MiR-133a in Cardiac Hypertrophy through AMPK Activation and Reduced ERK1/2 Phosphorylation.
... A large body of evidence has supported an important role of the ERK1/2 kinase in the develop- ment of cardiac hypertrophy [34–36]. However, whether ERK1/2 involved in APN mediated regulation of miR-133a in ...
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Duration-controlled swimming exercise training induces cardiac hypertrophy in mice
... show cardiac hypertro- phy in rats (15,16), some investigators (17,18) have observed cardiac hypertrophy in mice trained in voluntary running protocols or intensity-controlled treadmill ...
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Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II.
... left cardiac ventricle and increased in early stages of cardiac ...left cardiac ventricle and that PDE2 activity increases in the early stages of cardiac hypertrophy through a ...
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Regression of cardiac hypertrophy in the SHR by combined renin-angiotensin system blockade and dietary sodium restriction
... of cardiac hypertrophy is poorly ...the cardiac effects of the renin-angiotensin system (RAS) blockade in the spontaneously hypertensive rat (SHR), using co-treatment with an angiotensin II receptor ...
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Renin angiotensin system and cardiac hypertrophy after sinoaortic denervation in rats
... Our results for left ventricle angiotensins show that SHR groups presented increased Ang II levels compared with WC. Classically, RAS is a systematic regulator in various biological activities. Ang II is the key effector ...
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ORIGINAL RESEARCH LOW CORONARY PERFUSION PRESSURE IS ASSOCIATED WITH ENDOCARDIAL FIBROSIS IN A RAT MODEL OF VOLUME OVERLOAD CARDIAC HYPERTROPHY
... Although hemodynamics—phase 1 data were not significantly associ- ated with the presence of myocardial fibrosis 4 weeks after aortocaval fis- tula, they correlated significantly with fibrosis found at 8 weeks. Among all ...
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Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats
... (29). Cardiac hypertrophy is known to occur in response to various stimuli such as pressure and volume ...and cardiac performance during physical effort has been emphasized by several studies ...
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N-Acetyl Cysteine Inhibits Endothelin-1-Induced ROS Dependent Cardiac Hypertrophy through Superoxide Dismutase Regulation
... ET-1-induced cardiac hypertrophy leading towards heart failure was due to the imbalance of different parameters including free radical-in- duced oxidative stress and antioxidative enzymes such as ...
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Hypertension is a conditional factor for the development of cardiac hypertrophy in type 2 diabetic mice.
... phic cardiac effect observed in hypertensive type 2 diabetic ...role cardiac pathophysiology ...the cardiac content of AGEs does not increase significantly as a result of diabetes and/or ...
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Focal adhesion kinase signaling in cardiac hypertrophy and failure
... and hypertrophy in cardiomyocytes ...cardiomyocyte hypertrophy induced by Shp2 de- pletion or biomechanical stress, highlighting a potentially critical role for AKT and mTOR as downstream mediators of the ...
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Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish.
... that cardiac hypertrophy could be induced by other mechanisms than anemic ...high-output cardiac remodeling process, which is a particular type of cardiac ...of cardiac ...
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The Effects of Trimetazidine on QT-interval Prolongation and Cardiac Hypertrophy in Diabetic Rats
... Our results indicated that alloxan injection significantly increased QT and QTc intervals and decreased heart rate, LVSP, LVDP, RPP, ±dp/dt max, and cardiac hypertrophy, SOD, GPx and CAT in the heart of the ...
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Pressure Overload-induced Cardiac Hypertrophy Varies According to Different Ligation Needle Sizes and Body Weights in Mice
... have cardiac afterloading that is more increased than that of low-weight mice with the same aortic ...Cardiomyocyte hypertrophy and collagen deposition histological ...
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Swimming training promotes cardiac remodeling and alters the expression of mRNA and protein levels involved in calcium handling in hypertensive rats
... overload, hypertrophy, and heart failure (Nakatsu et ...The cardiac hypertrophy is classified as eccentric or concentric (Weber et ...concentric hypertrophy (pathological) is caused by chronic ...
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Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy.
... with cardiac-specific FABP4 over- expression (Fig 2A) and two FABP4-TG mouse lines (line 1 and line 2) were ...weight, cardiac morphology and contractile function were similar to those non-transgenic ...and ...
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Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice.
... compensated hypertrophy and maintained cardiac function ...regulating cardiac capillary density both under normal physiological and under pressure overloaded ...of cardiac hypertrophy ...
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Cardiac Myocyte De Novo DNA Methyltransferases 3a/3b Are Dispensable for Cardiac Function and Remodeling after Chronic Pressure Overload in Mice.
... of cardiac hypertrophy with progression to cardiac dysfunction within four ...in cardiac CpG methylation might evolve very slowly and are not optimally gauged in the TAC ...heart ...
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Arq. Bras. Cardiol. vol.98 número4 en v98n4a11
... MicroRNAs (miRNAs) are a group of newly discovered small RNAs, non-coding, which represent one of the most exciting areas of modern medical science as they modulate a huge and complex regulatory network of gene ...
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