cerebral malaria
Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria.
... of cerebral malaria, we demonstrated that targeting this protein resulted in stabili- zation of the blood vessels in the brain, decreased the influx of inflammatory cells to the brain vessels, and preserved ...
21
Real-time imaging reveals the dynamics of leukocyte behaviour during experimental cerebral malaria pathogenesis.
... Cerebral malaria (CM) is a severe complication of Plasmo- dium falciparum infection that takes a significant toll on human life. Blockage of the brain blood vessels contributes to the clinical signs of CM, ...
17
Modulation of cerebral malaria by curcumin as an adjunctive therapy
... Fig. 1 – The blood–brain barrier (BBB) breakdown during cerebral malaria pathogenesis. The diagram shows the events and the possible mechanisms that play a vital role in CM. The mature forms (trophozoites ...
13
Cytokine response during non-cerebral and cerebral malaria: evidence of a failure to control inflammation as a cause of death in African adults
... of malaria patients, mainly adults, admitted at the Hôpital Principal de Dakar, ...Sénégal. Malaria is endemic in several areas in ...of malaria with a seasonal ...or cerebral malaria ...
20
Uncovering the role of IFNAR1 in Experimental Cerebral malaria
... Cerebral malaria is a severe and fatal form of clinical Plasmodium falciparum infection, resulting in brain injury from a damaging cascade of vascular, inflammatory and immunological host ...to ...
162
Phosphatidylinositol 3-Kinase γ is required for the development of experimental cerebral malaria.
... Experimental cerebral malaria (ECM) is characterized by a strong immune response, with leukocyte recruitment, blood-brain barrier breakdown and hemorrhage in the central ner- vous ...
13
Neurological sequelae in pediatric cerebral malaria: The Indian perspective
... bral malaria in a child” published in June 2012 issue of our esteemed journal (J Vector Borne Dis 49(2); ...post-cerebral malaria expressive aphasia in chil- dren from Indian subcontinent and ...
1
Plant Hormone Salicylic Acid Produced by a Malaria Parasite Controls Host Immunity and Cerebral Malaria Outcome.
... Fig 4. Parasite SA influences the cerebral malaria outcome. (A-C) Histological observation of infected mouse cerebellums. (A) Cerebellum infected by nahG-expressing parasites. Note the sequestrated ...
18
Specific depletion of Ly6C(hi) inflammatory monocytes prevents immunopathology in experimental cerebral malaria.
... Plasmodium berghei ANKA (PbA) infection of C57BL/6 mice leads to experimental cerebral malaria (ECM) that is commonly associated with serious T cell mediated damage. In other parasitic infection models, ...
22
Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria.
... (n = 7) showed unaltered MRI and MRA signals. By contrast, wild- type mice showed altered MRI, observable as a bilateral hyperintense signal at the corpus callosum and external capsule (Figure 2A), and a remarkable ...
12
CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo.
... Severe malaria syndromes, including cerebral malaria (CM), claim the lives of approximately 900,000 people annually, mostly children under the age of 5 living in sub-Saharan Africa ...in ...
14
Hyperbaric Oxygen Prevents Early Death Caused by Experimental Cerebral Malaria
... As previously reported, HBO therapy inhibits the development of Leishmania amazonensis and of a non-cerebral line of P. berghei [30,32,36]. To further explore the effects of HBO, we monitored the parasitemia ...
10
Carbon monoxide and brain sequestration of Plasmodium berghei ANKA in experimental cerebral malaria
... In contrast to the clinically silent liver stage, the blood stage of infection is when the malaria-associated pathology occurs. Each merozoite released from the liver invades a red blood cell (RBC) where asexually ...
89
A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria.
... and most die within 24–48 hours. Human patients with CM often come to medical attention well into coma, reflecting both the rapidity by which CM is manifest as well as the socio-economic challenges faced by the ...
12
Vascular dysfunction as a target for adjuvant therapy in cerebral malaria
... While directly providing exogenous NO or other va- sodilators such as calcium channel blockers constitute a potentially translatable strategy to restore cerebral per- fusion during CM, a better understanding of ...
12
J. Pediatr. (Rio J.) vol.91 número6
... In malaria-endemic areas, most acute seizures are caused by malaria, but whether they are febrile seizures or acute symptomatic seizures is ...and cerebral malaria (CM) as a consequence mostly ...
3
Plasmodium berghei ANKA infection induces thymocyte apoptosis and thymocyte depletion in CBA mice
... to malaria infections are characterized by strong T and B cell activation, which, in addition of potentially causing immunopathology, are of poor efficacy against the ...of cerebral malaria or ...
6
The role of animal models for research on severe malaria.
... severe malaria have focused on infection by the malaria parasite Plasmodium ...severe malaria show signs of profound metabolic derangement and cerebral ma- laria, and may have placental ...
9
Arq. NeuroPsiquiatr. vol.50 número1
... Clinical Manifestations — Cerebral malaria may present abruptly or develop as a late complication in the progressive worsening of falciparum malaria with multisystem involvement.. Ther[r] ...
7
Maternal malaria induces a procoagulant and antifibrinolytic state that is embryotoxic but responsive to anticoagulant therapy.
... for malaria-associated poor birth ...severe malaria in non-pregnant ...pediatric cerebral malaria with unfractionated heparin and antimalarial drug reduced morbidity and mortality ...in ...
15