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DNA binding

Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein.

Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein.

... Figure 5. TMEM18 suppresses gene expression. (A) An enhancerless reporter vector pGL3 (light gray bars) and the same vector with 15 repeats of GCT upstream of the promoter (dark gray bars) were used in the luciferase ...

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Nε-lysine acetylation of a bacterial transcription factor inhibits Its DNA-binding activity.

Nε-lysine acetylation of a bacterial transcription factor inhibits Its DNA-binding activity.

... RcsB- DNA complex was reported to be unstable, and the role of RcsA proposed to stabilize this interaction ...on binding to its targets [47], and that CobB was able to regulate chemotaxis by deacetylation ...

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Arylsubstituted Ruthenium(II) complexes: a strategy for enhanced photocleavage and efficient DNA binding

Arylsubstituted Ruthenium(II) complexes: a strategy for enhanced photocleavage and efficient DNA binding

... ruplexes, B-DNA, Z-DNA, mismatches, CC- and GC-rich sequences, etc.), the metallointercalators, in general, present a well-defined symmetry and rigid structure. 5 In order to enhance DNA ...

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MARs Wars: heterogeneity and clustering of DNA-binding domains in the nuclear matrix

MARs Wars: heterogeneity and clustering of DNA-binding domains in the nuclear matrix

... containing binding site for the F326 protein enhances binding of heterologous MARs to the nuclear ...of DNA-binding sites on the nuclear ...the binding site for the F326 protein can ...

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Detection of cell carcinogenic transformation by a quadruplex DNA binding fluorescent probe.

Detection of cell carcinogenic transformation by a quadruplex DNA binding fluorescent probe.

... Cancer can be easily treated when found early. A probe capable of detecting cell transformation may increase the success rate of early diagnosis of cancer. In this report we have tested the ability of a fluorescent, ...

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Functional importance of the DNA binding activity of Candida albicans Czf1p.

Functional importance of the DNA binding activity of Candida albicans Czf1p.

... lexA DNA-binding domain bait fusion (indicated below columns) and a Gal4 activation domain prey fusion (black bars, Gal4AD- Efg1; white bars, Gal4AD-Slk19) were grown in synthetic complete medium lacking ...

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A type IV pilus mediates DNA binding during natural transformation in Streptococcus pneumoniae.

A type IV pilus mediates DNA binding during natural transformation in Streptococcus pneumoniae.

... primary DNA receptor at the surface of transformable Gram-positive bacteria is not ...cellular DNA at the surface of competent Gram-positive bacteria ...that DNA naturally released in the culture ...

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DNA binding of centromere protein C (CENPC) is stabilized by single-stranded RNA.

DNA binding of centromere protein C (CENPC) is stabilized by single-stranded RNA.

... the DNA sequence of centromeres has little or no role in perpetuating ...of DNA sequence ...that DNA binding is conferred by a localized region 122 amino acids long, and that the ...

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The inhibition of anti-DNA binding to DNA by nucleic acid binding polymers.

The inhibition of anti-DNA binding to DNA by nucleic acid binding polymers.

... bind DNA is extensive and, depending on intended use, NABPs can be mixed with other molecular entities to provide properties suited for vector ...with DNA and protection against nucleases prior to ...

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Damaged DNA binding protein 2 plays a role in breast cancer cell growth.

Damaged DNA binding protein 2 plays a role in breast cancer cell growth.

... Damaged DNA binding protein 2 (DDB2), is involved in nucleotide excision repair as well as in other biological processes in normal cells, including transcription and cell cycle ...

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Probing the informational and regulatory plasticity of a transcription factor DNA-binding domain.

Probing the informational and regulatory plasticity of a transcription factor DNA-binding domain.

... their binding sites must have enough information to be distinguishable from all other sequences in the genome, and (2) they must bind these sites with an affinity that appropriately modulates the rate of ...the ...

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Expression, purification and DNA-binding activities of two putative ModE proteins of Herbaspirillum seropedicae (Burkholderiales, Oxalobacteraceae)

Expression, purification and DNA-binding activities of two putative ModE proteins of Herbaspirillum seropedicae (Burkholderiales, Oxalobacteraceae)

... LB400 (GenBank YP_553832; 80% identity) and Burkholderia vietnamiensis G4 (GenBank YP_001115213; 70% identity). The protein we deduced from the modE1 produced a protein containing 269 amino acids and a calculated ...

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Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target.

Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target.

... duplex DNA (Figure ...[21–23]) DNA-binding domain and the ...for DNA-binding proteins, with the active site Arg 117 and Tyr 118 on the neighboring ‘100-122’ loop (Figure ...

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Cooperative DNA Recognition Modulated by an Interplay between Protein-Protein Interactions and DNA-Mediated Allostery.

Cooperative DNA Recognition Modulated by an Interplay between Protein-Protein Interactions and DNA-Mediated Allostery.

... their DNA-binding cooperativity originates from either direct interactions or DNA-mediated ...cooperative DNA recognition by OCT4 and SOX2, key components of enhanceosomes in pluripotent ...

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Mechanics and dynamics of X-chromosome pairing at X inactivation.

Mechanics and dynamics of X-chromosome pairing at X inactivation.

... For a given value of c, the route to colocalization could be taken, analogously, by increasing E, as a result, for instance, of modifications of the DNA binding regions or of mediating molecular complexes. ...

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Molecular evidence for a functional ecdysone signaling system in Brugia malayi.

Molecular evidence for a functional ecdysone signaling system in Brugia malayi.

... shaded: DNA Binding Domain (DBD - light gray), Ligand Binding Domain (LBD - dark gray), other coding regions ...The DNA Binding Domain, T/A Box, LBD helices and AF2 region are ...

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Binding of histone H1 to DNA is differentially modulated by redox state of HMGB1.

Binding of histone H1 to DNA is differentially modulated by redox state of HMGB1.

... or DNA minicircles than HMGB1 (this report), enabling replacement of H1 by ...only DNA binding affinities of HMGB1 and histone H1 are decisive in mutual competition of the proteins for DNA ...

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J. Braz. Chem. Soc.  vol.28 número8

J. Braz. Chem. Soc. vol.28 número8

... of binding, involving a strong stacking interaction between extending aromaticity of ligand and the base pairs of ...on DNA binding ...intrinsic binding constant (K b ) has been determined ...

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Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas.

Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas.

... that DNA methylation of the MT3 gene is linked with unique histone modifications in regulating gene ...of DNA binding in B, C and D was determined by normalizing the indicated histone binding ...

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Characterization of Dnmt1 Binding and DNA Methylation on Nucleosomes and Nucleosomal Arrays.

Characterization of Dnmt1 Binding and DNA Methylation on Nucleosomes and Nucleosomal Arrays.

... ger DNA fragments both Dnmt1 molecules of the dimer bind to DNA, implying that the bind- ing of a single Dnmt1 molecule to a 30 bp long DNA fragment would be ...existent DNA length sensing ...

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