Endoplasmic reticulum stress
Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis
... web: endoplasmic reticulum stress, inflammation, and oxidative ...ROS-mediated endoplasmic reticulum stress via the JNK/p38 activation pathways in human cervical cancer ...
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Mechanical strain downregulates C/EBPβ in MSC and decreases endoplasmic reticulum stress.
... trigger endoplasmic reticulum stress in pancreatic b-cells and fibroblasts [16,17], we considered whether C/EBPb might play a similar role in the MSC unfolded protein ...ER stress [39], a ...
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Role of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosis.
... of endoplasmic reticulum stress (ER-stress) indicators: phosphorylated eukaryotic initiation factor 2-alpha (peIF-2a) and glucose-regulated protein of 78kDA (GRP78) also known as BiP (Fig 3A), ...
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Transcriptional regulation of VEGFA by the endoplasmic reticulum stress transducer OASIS in ARPE-19 cells.
... to endoplasmic reticulum stressors, VEGFA mRNA was significantly ...after endoplasmic reticulum stress, we carried out reporter assays using an approximately 6-kbp 59-upstream region of ...
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Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract.
... The accumulation of germline and/or somatic mutations in ‘‘normal’’ cells results in an inability to overcome cell cycle and apoptotic checkpoints thereby resulting in the initiation of cancer. As the proliferation of ...
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Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells.
... the endoplasmic reticulum marker calreticulin, suggesting that resting NLRP3 localizes to endoplasmic reticulum structures ...induced endoplasmic reticulum stress in ...
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Homocysteine inhibits hepatocyte proliferation via endoplasmic reticulum stress.
... Homocysteine is an independent risk factor for coronary, cerebral, and peripheral vascular diseases. Recent studies have shown that levels of homocysteine are elevated in patients with impaired hepatic function, but the ...
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Induction of premature senescence in human fibroblasts through endoplasmic reticulum stress: protection by phenolic diterpenes
... The endoplasmic reticulum (ER) is a multifunctional organelle constituted by a network of membranes that extends throughout the nucleus to the cytoplasm (Naidoo, ...ER stress. The ER stress ...
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The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress.
... ER stress-induced pro-apoptotic proteins c-Jun N-terminal kinase (JNK) and tribbles- related protein 3 (TRB3) for ubiquitin-proteasome degradation ...ER stress induction raises the possibility that APC/ C ...
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Lithocholic acid induces endoplasmic reticulum stress, autophagy and mitochondrial dysfunction in human prostate cancer cells
... ER stress in causing the cytotoxicity of LCA to PC-3 and DU-145 cells, each cell type was pretreated for 4 h with salubrinal, a selective inhibitor of eIF2α dephosphorylation, before exposure to toxic ...
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Proteasome inhibition represses unfolded protein response and Nox4, sensitizing vascular cells to endoplasmic reticulum stress-induced death.
... The mechanisms whereby proteasome inhibition suppressed the UPR in our VSMC are unknown. In striking contrast with the other UPR markers assessed in our cells, as well as with findings reported for myeloma cells [11], ...
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Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner.
... ER stress differentially regulates Thr308 and Ser473 phosphorylation, and that the ratio between the two residues could be important in determining AKT’s downstream substrate ...ER stress regulates AKT ...
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Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.
... to endoplasmic reticulum (ER) function in neurons, with reduced levels provoking ER stress and increasing vulnerability to excitotoxic ...ER stress and seizure-damage despite down-regulation ...
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HIV protease inhibitors disrupt lipid metabolism by activating endoplasmic reticulum stress and inhibiting autophagy activity in adipocytes.
... To further determine the effect of HIV PIs on autophagic degradation, we examined the effect of LPV and LPV/RTV on the accumulation of p62. p62 is a nuclear membrane protein proposed to be specifically degraded through ...
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Violacein Induces Death of Resistant Leukaemia Cells via Kinome Reprogramming, Endoplasmic Reticulum Stress and Golgi Apparatus Collapse
... Studies of cellular biochemistry, ultrastructural morphology and inhibitors of apoptosis, autophagy and pyroptosis indicate that violacein acts through a molecular mechanism distinct from these known manifestations of ...
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HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.
... ER stress conditions, and if so, is adaptation to continuous ER stress, which was demonstrated to occur in response to pharmacological ER agents ...ER stress conferred adaptation and resistance to ...
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The Role of the Endoplasmic Reticulum Stress Transducer Ire1 during Photoreceptor Differentiation in Drosophila
... The UPR has been regarded as an emergency cellular response to the accumulation of misfolded proteins intrinsically associated with pathogenic conditions. However, the UPR activates processes as amino acid import and ...
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Novel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits leukemic mice.
... ER stress, we investigated several vital hallmarks of UPR, including C/EBP homologous protein (CHOP), immunoglobulin heavy chain binding protein (BiP), glucose-regulated protein 94 (GRP94), alpha subunit of ...
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Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling.
... Endoplasmic reticulum (ER), an intracellular membranous network, plays a crucial role in the maintenance of normal cardiac function through managing intracellular Ca 2+ storage, folding and processing of ...
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Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function.
... ER stress (13del proteins) to a more acceptable ...ER stress in ...ER stress in ...ER stress either by undergoing apoptosis or by a general down-regulation of protein synthesis and ...
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