Fine Mapping
Fine mapping of the Bsr1 barley stripe mosaic virus resistance gene in the model grass Brachypodium distachyon.
... rapid mapping of Bsr1 to the top of Chr 3, and additional markers developed from Bd3-1 resequencing data allowed Bsr1 to be Figure ...the fine mapping ...
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Systematic fine-mapping of association with BMI and type 2 diabetes at the FTO locus by integrating results from multiple ethnic groups.
... trans-ethnic fine mapping is thought to be that the LD between the observed (or tag) SNPs showing association and the unknown causal variant(s) is similar across different populations even if the degree of ...
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Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping.
... the fine mapping ...for fine mapping leads to extreme LD, which presents two specific challenges for ...Bayesian fine mapping framework which assumes a single causal variant per ...
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A fine-mapping study of 7 top scoring genes from a GWAS for major depressive disorder.
... After genotyping, several SNPs were excluded through quality control. Even though we did improve coverage significantly, due to this exclusion we did not acquire full coverage for all genes. Full coverage was reached ...
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Fine mapping and single nucleotide polymorphism effects estimation on pig chromosomes 1, 4, 7, 8, 17 and X
... performing fine mapping is how to analyze the data and combine the resulting infor- mation, since linkage mapping and genome-wide associa- tion (GWA) use different statistical ...Linkage ...
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Identification and Fine Mapping of a White Husk Gene in Barley (Hordeum vulgare L.).
... ual plants and used 1115 individuals with white husk of them to test the five polymorphic markers in the preliminary mapping results. Meanwhile, to identify more molecular markers linked with this gene, we ...
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Fine mapping and single nucleotide polymorphism effects estimation on pig chromosomes 1, 4, 7, 8, 17 and X
... a fine mapping study was performed on pig chromosomes 1, 4, 7, 8, 17 and X to determine their association with performance, carcass, internal organs, cut yields and meat quality ...interval mapping ...
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Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.
... From each GWAS we extracted SNPs within the extended MHC region (chr6:29,299,390 to 33,883,424; hg18) to impute classical alleles for class I HLA genes (HLA-A, HLA-B, and HLA-C) and class II HLA genes (HLA-DPA1, ...
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Integrating functional data to prioritize causal variants in statistical fine-mapping studies.
... We find that prioritizing variants using PAINTOR posterior probabilities achieves superior accuracy over existing methodol- ogies (see Figure 2 and Table 1). Our approach identifies more causal variants at all selection ...
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Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci.
... of fine-mapping strategies have been advocated, and specific successes reported, but the overall performance of such approaches, in the face of the extensive linkage disequilibrium that characterizes the ...
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Fine mapping and candidate gene prediction of a pleiotropic quantitative trait locus for yield-related trait in Zea mays.
... Maize grain yield (GY) is the most important breeding goal, and is one of the most complex traits [1], because it comprises several yield components including kernel number (KN) and kernel weight (KW). Furthermore, the ...
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Fine mapping of dominant X-linked incompatibility alleles in Drosophila hybrids.
... cross. We fitted a general linear model for each developmental stage for each species in which the relative viability was the response, and the genotype (identity of the duplication) and the genetic background (i.e., the ...
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Monoclonal antibodies to the V2 domain of MN-rgp120: fine mapping of epitopes and inhibition of α4β7 binding.
... screened for reactivity to the MN-rgp120 V2 domain. For this purpose, a novel epitope mapping strategy was employed using a panel of overlapping fragments of MN-rgp120, expressed in mammalian cells (Figure 1, ...
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Replication and fine mapping for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in the Chinese population.
... A recent genome-wide association study (GWAS) identified five novel susceptibility loci for prostate cancer in the Japanese population.. This study is to replicate and fine map the poten[r] ...
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Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.
... We evaluated also associations in regions surrounding known (GWAS) risk alleles as a partial fine-mapping exercise; we specifically focused upon (1) coding alleles reported to be in high[r] ...
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Genetic variants at 1p11.2 and breast cancer risk: a two-stage study in Chinese women.
... A total of 1,792 breast cancer cases and 1,867 cancer-free controls were included in this study. All subjects were genetically unrelated ethnic Han Chinese women from Nanjing City and surrounding regions in southeast ...
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Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping.
... performed fine mapping of established GWAS loci in a well characterized prospectively recruited pediatric onset IBD cases and con- trol study, using a high-density custom array ...
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Shu Xia Sun 1,2, , Fang Yuan Gao 2, , Xian Jun Lu2 , Xian Jun Wu
... the mapping population in our ...for fine mapping and further analysis nar- rowed the location of the aroma locus to a 2 cM interval flanking RM515 and ...our mapping was ...
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Comparative analysis of disease-linked single nucleotide polymorphic markers from Brassica rapa for their applicability to Brassica oleracea.
... In the present study, we evaluated whether 7,645 SNPs linked to disease resistance from the B. rapa genome may be applied to B. oleracea. A total of 693 SNP markers, including 145 SNP markers (BRH) developed from the B. ...
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Eye movements reveal effects of visual content on eye guidance and lexical access during reading.
... or fine visual content was present, leading Leat and Munger to argue that a range of different visual content can produce normal reading ...very fine visual content was ...or fine visual content was ...
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