HDAC Inhibitors
HDACs and HDAC inhibitors
... expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chromatin remodeling and have been extensively studied as potential drugs for treating of spinal ...
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Imbalance between HAT and HDAC activities in the PBMCs of patients with ankylosing spondylitis or rheumatoid arthritis and influence of HDAC inhibitors on TNF alpha production.
... We observed in both AS and RA that TSA, but not Sirt, tended to induce TNF production at day one. These results are consistent with a preferential activation of the human TNF promoter by TSA in transfected U937 cells, ...
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In Vivo Screening Using Transgenic Zebrafish Embryos Reveals New Effects of HDAC Inhibitors Trichostatin A and Valproic Acid on Organogenesis.
... are inhibitors of histone deacetylases (HDACs), which are recruited by transcription factors (especially nuclear receptors) and associated with transcriptional repression ...that HDAC-1 is required for the ...
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HDAC inhibitors repress BARD1 isoform expression in acute myeloid leukemia cells via activation of miR-19a and/or b.
... To determine whether Vorinostat-induced BARD1 down- regulation was an exclusive event of human Aεδ cells, we evaluated BARD1 expression levels in other human cancer [r] ...
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Putative Epigenetic Involvement of the Endocannabinoid System in Anxiety- and Depression-Related Behaviors Caused by Nicotine as a Stressor.
... (HDAC) inhibitors was investigated in anxiety- and depres- sion-related behavioral alterations caused by NC and/or immobilization stress ...of HDAC inhibitors was evaluated in order to examine ...
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Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells.
... that HDAC inhibitor treatment enhanced oHSV replication in tumor cells but not normal cells, we postulated that HDAC inhibitor treatment might make an oHSV-resistant line more susceptible to viral ...the ...
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Epigenetic therapy in urologic cancers: an update on clinical trials
... employing HDAC inhibitors showed a positive response; in this trial, four of fifteen patients treated with the HDACi Belinostat in combination with Carboplatin or Paclitaxel showed complete or partial ...
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Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo.
... diphenylamide HDAC inhibitors in cell and mouse models of FRDA and HD, we evaluated the HDAC isoform selectivity, cellular activity, in vitro and in vivo ADME properties of the preclinical prototype ...
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Sonic hedgehog-induced histone deacetylase activation is required for cerebellar granule precursor hyperplasia in medulloblastoma.
... various HDAC inhibitors have shown anti- tumor effects in pre-clinical tumor models ...medulloblastoma, HDAC expression and activity of various HDAC family members, including HDAC1, 2, 3 and 6 ...
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Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells.
... accordingly, HDAC inhibitors induce Bax upregulation ...by HDAC inhibitors, compounded by sirtuin inhibition, could be a vital factor making leukemia cells especially susceptible to mitochon- ...
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Interference of the Histone Deacetylase Inhibits Pollen Germination and Pollen Tube Growth in Picea wilsonii Mast.
... cells. HDAC has been reported to play a role in ...of HDAC on androgamete development remains unclear, especially in ...the HDAC inhibitors trichostatin A (TSA) and sodium butyrate (NaB) to ...
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Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development.
... in HDAC inhibitors as potential drug candidates in the treatment of cancer, degenerative diseases and effects on learning and memory [40,41], it is necessary to study the functions of individual HDACs in ...
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Genetic and epigenetic mechanisms involved in regulation of STEAP1 gene expression in LNCaP prostate cancer cells
... Prostate cancer is the second most frequently diagnosed type of cancer and the fifth leading cause of cancer death in men worldwide. Prostate carcinogenesis is characterized by progressive alterations in genetic and ...
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The effects of histone deacetylase inhibition on the levels of cerebral cytokines in an animal model of mania induced by
... [73]. Inhibitors of HDAC induced microglial apoptosis, which could be related to their neuropro- tective effects in response to proinflammatory stimuli [70, ...that HDAC inhibitors prevent the ...
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The anti-epileptic drug valproic acid (VPA) inhibits steroidogenesis in bovine theca and granulosa cells in vitro.
... (HDAC) inhibitors trichostatin A and scriptaid also suppressed TC androstenedione secretion and granulosal cell oestrogen secretion suggesting that the action of VPA reflects its HDAC inhibitory ...
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PknE, a serine/threonine protein kinase of Mycobacterium tuberculosis initiates survival crosstalk that also impacts HIV coinfection.
... For the first time, we show that DpknE induces apoptosis and down modulates intracellular events that suppress CCR5 expres- sion. This concurs with a previous study where CCR5 was shown to induce antiapoptotic signals ...
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Anti-Inflammatory Activity of <i>Vitex leucoxylon</i> L. Bark Extracts Against Freund's Complete Adjuvant Induced Arthritis in Sprague Dawley Rat
... Abstract: Problem statement: Anti-inflammatory agents, particularly steroids and cyclooxygenase inhibitors are often associated with adverse side effects including, GI irritation, ulcers, hypertension and cardiac ...
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J. Braz. Chem. Soc. vol.23 número11
... between inhibitors and receptor such as hydrophobic, hydrogen bonding, salt bridge, close contact and π ...the inhibitors. Finally, new potent inhibitors will be proposed based on the results ...
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Purification and biochemical properties of a salivary α-amylase in Andrallus spinidens Fabricius (Hemiptera: Pentatomidae)
... Effect of specific inhibitors on α -amylase activity The effects of enzyme inhibitors on amylolytic activity were studied using different concentrations (0, 0.5, 1, 3, 5 and 10 mM) [r] ...
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Small molecule inhibitors of CRM1
... et al., 2012; Lapalombella et al., 2012; Ranganathan et al., 2012). The first molecule of this family of small molecule compounds was found by a screening effort aimed to identify new anti-HIV Rev inhibitors ...
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