HIF-1α
Análise imuno-histoquímica das proteínas VEGF e HIF-1α na doença periodontal
... o HIF-1 α (Fator induzido por hipóxia -1 ...para HIF-1 α, nos espécimes de periodontite e gengivites crônicas, em relação aos sítios saudáveis, porém, sem diferenças estatísticas entre elas ...e ...
92
Discovery of novel inhibitors disrupting HIF-1α/von Hippel–Lindau interaction through shape-based screening and cascade docking
... for HIF-1α/pVHL protein–protein interaction, the strategy presented here com- bined both shape-based pharmacophore model and cascade docking based on the idea that molecules with similar shape tend to ...
14
Imunoexpressão de VEGF-C, VEGFR-3 e HIF-1α e mensuração da densidade linfática em carcinomas epidermóides de lábio inferior metastáticos e não-metastáticos: uma relação com parâmetros clinicopatológicos e prognósticos
... de HIF- 1α, VEGF-C, LYVE-1 e CD34 em 65 amostras de carcinoma epidermóide oral e compararam esses dados com parâmetros ...de HIF- 1α na linfangiogênese e metástase de carcinoma epidermóide ...
222
Expressão Imuno-histoquímica das proteínas GLUT-1 e HIF-1α em lesões vasculares de mucosa oral
... do HIF-1α, o teste de Mann-Whitney revelou diferença estatisticamente significativa entre os casos de GP e MV(p=0,002), onde a mediana do GP (m=78) foi superior a da MV ...o HIF- 1α participa ...
111
INFLUÊNCIA da Exposição à Fumaça do Cigarro e Radioterapia na Expressão de Phd3, Hif-1α, Vegf, Sod-1, Ra2a e Foxp3 em Células do Infiltrado Inflamatório de Câncer Colorretal Induzido
... infiltrados intra e peritumorais de câncer colorretal induzido. Para tanto, foram utilizados 53 ratos Wistar, 5 com o intestino saudável como controle negativo (G0) e os 48 ratos restantes foram induzidos à tumorigênese ...
105
Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution.
... of HIF-2α in the developing mammary epithelium is less well characterised compared to that of HIF-1α ...of HIF-2α in the mouse mammary gland during development, lactation, and involution, we ...
15
Perfil da expressão de HIF-1α em células linfoides do infiltrado inflamatório peritumoral e intratumoral como marcador prognóstico do carcinoma epidermoide de cavidade oral
... da HIF-1α em linfócitos do infiltrado inflamatório peritumoral e forte em linfócitos do infiltrado inflamatório intratumoral representa o perfil de baixo risco e está associado ao melhor prognóstico sem ...
55
Expressão Imuno-histoquímica de COX-2, EMMPRIN, HIF-1α e GLUT-1 no tecido gengival normal e inflamado
... o HIF-1α, GLUT-1 e EMMPRIN estavam fortemente expressos na camada basal do epitélio e a imunomarcação foi gradualmente diminuindo à medida que as células afastavam-se desta camada, sendo negativa na região ...
120
HIF-1α relevance in necrosis of mycobacterium avium-induced granulomas
... the HIF-1α gene only in myeloid cells including monocytes, mature macrophages and ...was HIF-1α heterozygous; the second generation obtained was HIF-1α heterozygous (single ...
69
Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth.
... downregulated HIF-1α and VEGF expression and inhibited Akt and ERK ...of HIF-1α by siRNA considerably augmented the BBR- mediated inhibition of cell ...NF-κB/COX-β, HIF-1α/VEGF, ...
13
Avaliação imuno-histológica de CD15, CD57 e HIF-1α em mucosa periimplantar
... YONEDA, M. et al. Stimulation of growth of porphyromonas gingivalis by cell extracts from Tannerella forsythia. Journal of periodontal research, v. 40, p. 105-109, 2005. ZAREMBER, K. A.; MALECH, H. L. ...
99
The suppressive effect of resveratrol on HIF-1α and VEGF expression after warm ischemia and reperfusion in rat liver.
... inhibiting HIF-1a and VEGF expression through multiple mechanisms, including the inhibition of AKT and mitogen-activated protein kinase activation, the inhibition of several protein translational regulators, and ...
5
Ginsenoside 20(S)-Rg3 targets HIF-1α to block hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cells.
... of HIF-1a [39]. Growing evidence demonstrates that hypoxia and HIF-1a are valid anti-cancer drug targets ...and HIF-1a, and particularly those with less cytotoxicity, will likely enjoy clinical ...
12
Dual inhibition of plasminogen kringle 5 on angiogenesis and chemotaxis suppresses tumor metastasis by targeting HIF-1α pathway.
... by HIF-1a, a major nuclear transcription factor modulating gene expression in response to hypoxic ...targeting HIF-1a suppressed SDF-1a-induced cell movement ...
14
PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1α expression in MCF-7 breast cancer cells.
... on HIF-1a protein and mRNA expressions in MCF-7 cells. As expected, HIF-1a protein levels increased approximately 2-folds in hypoxic cells compared with those in normoxic ...hypoxia-induced HIF-1a ...
9
High concentrations of L-ascorbic acid specifically inhibit the growth of human leukemic cells via downregulation of HIF-1α transcription.
... of HIF-1a and one of HIF- 1a-regulated molecules, VEGF, in leukemic ...cells. HIF-1a and VEGF are considered as potential targets for cancer therapy because they play an important role in the ...
11
Retinoblastoma binding protein 2 (RBP2) promotes HIF-1α-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway.
... of HIF-1a and VEGF were increased compared to the control; the PI3K/Akt inhibitor LY294002 significantly inhibited the expression of HIF-1a and VEGF in pcDNA3-HA-RBP2 SK-MES-1 cells ...
12
TNF-α mediated increase of HIF-1α inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI).
... The HIF-1a protein expression level in mouse lung tissues increased significantly at four hours and eight hours (**p, ...that HIF-1a acts downstream of TNF-a to inhibit VASP expression and to modulate the ...
10
PDGF upregulates Mcl-1 through activation of β-catenin and HIF-1α-dependent signaling in human prostate cancer cells.
... both HIF-1a and b-catenin were rapidly increased in the nucleus (Figure ...the HIF-1a immuno- precipitates (Figure 5C, upper ...nuclear HIF-1a with b-catenin following PDGF-BB treatment (Figure 5C, ...
12
Nicotine promotes proliferation of human nasopharyngeal carcinoma cells by regulating α7AChR, ERK, HIF-1α and VEGF/PEDF signaling.
... (B), HIF-1a-specific siRNA (si-HIF-1, 100 nM) or non-specific siRNA control (si-NS, 100 nM) (D, E) for 4 hours followed by nicotine (10 mM) treatment for 24 ...of HIF-1a proteins in NPC cells (C, E) ...
11