Homologous recombination DNA repair
Analysis of epigenetic alterations in homologous recombination dna repair genes in male breast cancer
... aberrant DNA methylation, in particular, is widely acknowledged as an early and relevant event in tumorigenesis [29], these have been seldom reported and with different purposes, in male BC ...
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Unveiling novel RecO distant orthologues involved in homologous recombination.
... intrachromosomal recombination are not required for ...some DNA substrates (Table ...intrachromosomal recombination (Figure ...incoming DNA is present in the cell as a ...
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DNA repair gene expressions are related to bone marrow cellularity in syndrome
... from DNA replication, spontan- eous chemical reactions and assaults by external or metabolism-derived ...damage repair pathways operate in mammals: nucleotide-excision repair (NER), base excision ...
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Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Homologous Recombination in Patients with Triple-Negative and Hereditary Non-Triple-Negative Breast Cancers.
... From a cohort of 1,255 consecutive breast cancer patients described previously [15] we studied a group of 165 consecutive women with TNBC unselected for family history and a group of 46 consecutive patients with Hn-TNBC. ...
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Either non-homologous ends joining or homologous recombination is required to repair double-strand breaks in the genome of macrophage-internalized Mycobacterium tuberculosis.
... including DNA. The accumulation of DNA damage in the form of oxidation, depurination, methylation, and deamination can cause single- and double-strand breaks (DSBs) that affect the integrity of the whole ...
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Single molecule PCR reveals similar patterns of non-homologous DSB repair in tobacco and Arabidopsis.
... several DNA repair pathways exist. When a homologous template is available, DNA repair may occur via homologous recombination (HR) ...of DNA damage or degradation ...
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ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.
... to DNA damaging agents is typically caused by loss of wild-type p53 ...to DNA damages is clearly complex and a reflection of p53’s multiple functions in apoptosis, cell-cycle control, and DNA ...
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A PHF8 homolog in C. elegans promotes DNA repair via homologous recombination.
... to DNA dam- ...interstrand DNA crosslinks (ICLs), while only mutation of ...strand DNA breaks ...of homologous recombination were ...mologous recombination either by relaxing ...
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Members of the RAD52 Epistasis Group Contribute to Mitochondrial Homologous Recombination and Double-Strand Break Repair in Saccharomyces cerevisiae.
... and repair of mtDNA is quite limited compared to our understanding of similar events in the ...nuclear DNA repair proteins are now known to also localize to mitochondria, but their function and the ...
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The HSP90 inhibitor NVP-AUY922 radiosensitizes by abrogation of homologous recombination resulting in mitotic entry with unresolved DNA damage.
... The present preclinical work shows that NVP-AUY922 is a promising candidate for translational clinical studies in conjunc- tion with external beam radiotherapy in head and neck squamous cell carcinoma. The current body ...
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Frequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosis.
... between homologous chromosomes of different parental origin (homologs) is necessary for their accurate segregation during ...inter-homolog recombination is promoted by a barrier to inter-sister-chromatid ...
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Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer
... DSB repair requires a homologous DNA se- quence provided by the sister homologous chromatid to re- store a DSB ...single-strand DNA binding protein 1 (hSSB1) binds to the free 3’ ends ...
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Impact of NGS in the medical sciences: Genetic syndromes with an increased risk of developing cancer as an example of the use of new technologies
... a DNA DSB sensor and activator of ...sion repair as well as in transcription as chromatin remodel- ing ...recognition, homologous recombination, chro- mosome integrity, cell division, and ...
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Genome-wide analysis of heteroduplex DNA in mismatch repair-deficient yeast cells reveals novel properties of meiotic recombination pathways.
... DSB repair pathways. For simplicity, only two homologous DNA molecules are represented, one red and one ...39 DNA end is identified by an arrow when appropriate. Newly synthesized DNA ...
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Construction of yellow fever virus subgenomic replicons by yeast-based homologous recombination cloning technique
... linear DNA fragments can efficiently stimulate recombination in Saccharomyces cerevisiae has led to the rapid development of powerful methods for DNA manipulation in yeast (Oldenburg et ...based ...
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Effects of UV radiation exposure on DNA and DNA repair enzymes
... of DNA injuries, cells have developed a sophisticated DNA maintenance apparatus, consisting of different repair systems (Figure ...of DNA lesion, as a whole they counteract most of the ...
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Mre11-Rad50 promotes rapid repair of DNA damage in the polyploid archaeon Haloferax volcanii by restraining homologous recombination.
... DSB repair was similar to that observed with pTA274 (data not ...stranded DNA. The fraction of single-stranded DNA in cells irradiated with UV was measured by slot blotting and hybridiza- tion, using ...
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Competitive repair by naturally dispersed repetitive DNA during non-allelic homologous recombination.
... Figure 1. Ty retrotransposon elements in S. cerevisiae are tractable repetitive families to study non-allelic homologous recombination (NAHR). (A) Diagram showing the insertion sites for Ty1/Ty2 families of ...
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A functional metagenomics approach to identify novel ultraviolet resistance genes
... is DNA damage, there are several DNA repair mechanisms that ensure ...Excision repair, (BER) Base excision repair; (MMR) Mismatch repair, (HR) Homologous ...
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Gene homozygosis and mitotic recombination induced by camptothecin and irinotecan in Aspergillus nidulans diploid cells
... I DNA complex, preventing the next DNA re- ligation ...into DNA double- strand breaks (DSB) upon collision with replication ...the homologous recombination repair ...and ...
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