Hypoxia inducible factor 1α
Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.
... growth factor re- ceptor (EGFR)-mediated aberrant signaling transduction is crucial in HNSCC tumorigenesis and progression ...[13]. Hypoxia-inducible factor-1α (HIF-1α) is a ...
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Altered expression of hypoxia-inducible factor-1α (HIF-1α) and its regulatory genes in gastric cancer tissues.
... regulatory factor (IRF)-1 is also an immune active molecule and inflammatory process regulator, the activation of IRF-1 and NF-kB was found to be concurrently activated in melanoma ...trefoil factor 3(TFF3) ...
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SHARP1 suppresses angiogenesis of endometrial cancer by decreasing hypoxia-inducible factor-1α level.
... decreasing hypoxia-inducible factor-1a (HIF-1a), inhibited cell viability and tumor growth in ...under hypoxia. Upregulation of SHARP1 in EC impeded hypoxia-induced angiogenesis by ...
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Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α.
... To further assess the role of PIN1 in angiogenesis in an animal model, we conducted a Matrigel plug assay in nude mice. For this purpose, HCT116/5xHRE-ODD-luc cells were infected with control or sh-PIN1 lentiviruses. The ...
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Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1
... of hypoxia-inducible factor- 1α (HIF-1α) were detected in response to glucose stimulation and that MIN6 cells overexpressing HIF-1α were resistant to glucose-induced ...
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Int. braz j urol. vol.36 número1
... Tissue hypoxia can be evaluated by measuring the levels of hypoxia inducible factor-1α ...growth factor (VEGF) up-regulation and the regulation of cellular metabolism in diseases ...
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Ginsenoside 20(S)-Rg3 targets HIF-1α to block hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cells.
... blocks hypoxia-induced EMT of ovarian cancer cells in vitro and in ...of hypoxia-inducible factor 1a (HIF-1a) by activating the ubiquitin-proteasome pathway to promote HIF-1a ...
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An association study between hypoxia inducible factor-1alpha (HIF-1α) polymorphisms and osteonecrosis.
... Bone hypoxia resulting from impaired blood flow is the final pathway for the development of osteonecrosis ...transcription factor triggered by hypoxia, is genetically implicated in susceptibility to ...
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Cobalt-alloy implant debris induce HIF-1α hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure.
... implants. Hypoxia-associated responses to Cobalt-alloy metal debris were suspected as mediating this untoward reactivity at least in ...part. Hypoxia Inducible Factor-1a is a major ...
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J. Bras. Patol. Med. Lab. vol.49 número1
... resistance. Hypoxia inducible factor (HIF)-1α is responsible for hypoxia in the tumor microenvironment and its molecular mechanisms as well as its therapeutic strategies have been ...to ...
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CITED2 and the modulation of the hypoxic response in cancer
... with hypoxia-inducible factors to modulate the response to ...CITED2, hypoxia-inducible factor (HIF)-1α and ...under hypoxia. To this end, HIF-1α binds to the CH1 ...
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Putative role of ischemic postconditioning in a rat model of limb ischemia and reperfusion: involvement of hypoxia-inducible factor-1a expression
... Hypoxia-inducible factor-1a (HIF-1a) is one of the most potent angiogenic growth factors. It improves angiogenesis and tissue perfusion in ischemic skeletal muscle. In the present study, we tested ...
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Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryo.
... Recently, hypoxic cells were found in the mouse fetal liver (e11.0) by hypoxic probe staining [38]. Here, we hypothesized that hif is involved in the process of liver development in the zebrafish embryo. hif2-alpha-null ...
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CoDAS vol.28 número2
... Hearing loss due to hypoxia has been shown to be temporary in most cases. However, there are few studies in the area that demonstrate how this mechanism recovers. Studies show that there is a temporary change in ...
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The role of hypoxia in glioblastoma invasion
... that hypoxia regulates PLOD2 protein expression in a HIF-1α dependent manner and that the knockdown of PLOD2 by shRNA significantly inhibits GBM cell migration and invasion ...
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Inducible nitric oxide synthase and tumor necrosis factor- α
... tissue inducible NOS (iNOS) and neuronal NOS (nNOS) protein expressions at 8 h after LPS (when iNOS expression is considered to be high), as described be- ...
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The anti-proliferative effect of L-carnosine correlates with a decreased expression of hypoxia inducible factor 1 alpha in human colon cancer cells.
... growth factor, and the EGF) ...transcriptional factor is required to its transcriptional ...the hypoxia response element (HRE)-luciferase reporter plasmid, containing the sequence recognized by ...
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hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors.
... promoter activity and gene expression of CD133 in lung cancer cell lines [20]. In addition, Oct3/4 and Sox2, both of which are induced by HIF-1a and HIF-2a, promoted CD133 expression through their direct interaction with ...
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Characterization of the activation of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) by hypoxia inducible factor-2 alpha.
... The PTPRZ1 promoter constructs were transiently transfected into HEK293T or Hep3B cells along with plasmids encoding HIF- 1a, HIF-2a, or their degradation-resistant forms (drHIF-1a or drHIF-2a). HIF accumulation in the ...
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Analysis of the stress-inducible transcription factor SsNAC23 in sugarcane plants
... (Hypoxia-inducible factor 1- like), in which a reduction in one cysteine residue in the HLF protein is essential for its interaction with the CBP/ p300 complex (Ema et ...
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