Innate immunity
Transcriptional responses of Leptospira interrogans to host innate immunity: significant changes in metabolism, oxygen tolerance, and outer membrane.
... Co-cultivation of pathogenic Leptospira with host immune cells is widely used as an infection model to study leptospirosis [19,20]. Although pathogenic Leptospira is not considered a typical intracellular pathogen, ...
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Innate immunity drives the initiation of a murine model of primary biliary cirrhosis.
... In this study, we investigated the effect of administration of OCH on the natural history of xenobiotic induced autoimmune cholangitis. We report herein that mice administered with OCH have exacerbated portal ...
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Clostridium difficile modulates host innate immunity via toxin-independent and dependent mechanism(s).
... Infection with strains R20291 and 630 also mediated significant IL-1b secretion in the ex-vivo model of infection (Fig. 1B). To date, C. difficile toxins and SLPs have been implicated in mediating IL- 1b secretion ...
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Murine and bovine γδ T cells enhance innate immunity against Brucella abortus infections.
... suggesting that the protective function of cd T cells may be limited to innate immunity. In addition, the temporal protection conferred by cd T cells correlates with the theory that cd T cells may be a link ...
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Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis
... 20. Sato N, Kinbara M, Kuroishi T, Kimura K, Iwakura Y, Ohtsu H, et al. Lipopolysaccharide promotes and augments metal allergies in mice, dependent on innate immunity and histidine decarboxylase. Clin Exp ...
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THE INNATE IMMUNITY IN BOVINE MASTITIS: THE ROLE OF PATTERN-RECOGNITION RECEPTORS
... The incidence and severity of septic E. coli mastitis in dairy cattle is mainly dependent on cow factors. During the periparturient period, the non-specific or innate immunity of the cow is depressed, which ...
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Dengue virus targets the adaptor protein MITA to subvert host innate immunity.
... To ascertain whether cleavage of MITA discredits innate immunity in response to DEN infection, we established stable A549 cells overexpressing MITA or MPYS by lentiviral transduc- tion. MITA is a DNA sensor ...
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Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity.
... Defining the mechanisms of Mycobacterium tuberculosis (Mtb) persistence in the host macrophage and identifying mycobacterial factors responsible for it are keys to better understand tuberculosis pathogenesis. The ...
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The DAF-16/FOXO transcription factor functions as a regulator of epidermal innate immunity.
... epidermal innate immunity in other species ...of innate immunity in epidermal tissues seems to be evolutionarily conserved in various animal species including worms, insects and ...
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Nucleolar proteins suppress Caenorhabditis elegans innate immunity by inhibiting p53/CEP-1.
... enhanced immunity of nol-6 RNAi nematodes (Figure 6B and ...and immunity in Drosophila, SYM-1 may regulate the two processes in ...elegans immunity against ...for immunity in ...of ...
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Innate immunity in fruit flies: a textbook example of genomic recycling.
... Adaptive immunity is characterized by greater specifi city than innate immunity, as the adaptive immune response can not only distinguish foreign cells from self, but can also distinguish one foreign ...
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Isonitrosoacetophenone drives transcriptional reprogramming in Nicotiana tabacum cells in support of innate immunity and defense.
... in innate immunity and disease resistance- related signaling events ...nate immunity that interacts with HSP90 and SGT1 to maintain proper NB-LRR protein steady-state levels ...
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Trans-species polymorphism at antimicrobial innate immunity cathelicidin genes of Atlantic cod and related species
... Natural selection, the most important force in evolution, comes in three forms. Negative purifying selection removes deleterious variation and maintains adaptations. Positive directional selection fixes beneficial ...
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Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L.
... Theiler’s virus is a neurotropic picornavirus responsible for chronic infections of the central nervous system. The establishment of a persistent infection and the subsequent demyelinating disease triggered by the virus ...
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Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniae.
... Pattern recognition receptors (PRR) are essential for innate immunity to invading pathogens. One of the best-characterized groups of PRR is the family of Toll-like receptors (TLR). Signal transduction in ...
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Epithelial, metabolic and innate immunity transcriptomic signatures differentiating the rumen from other sheep and mammalian gastrointestinal tract tissues
... PIP, encoding prolactin-induced protein (an aspartyl protease), was preferentially expressed in the rumen (Fig. 3). In humans, PIP is also highly expressed in epidermal (Genevestigator (Hruz et al., 2008) analysis) and ...
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Serum bactericidal activity as indicator of innate immunity in pacu Piaractus mesopotamicus (Holmberg, 1887)
... evaluate innate defense systems since the immune system responses may be influenced or manipulated by several substances or ...by innate system, which has prompted acute phase proteins so as to protect fish ...
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Innate immunity in human embryonic stem cells: comparison with adult human endothelial cells.
... The lack of response to bacterial challenge may not be surprising for the undifferentiated hESC, given the delay in development of innate immune sensing in the embryo. Full TLR responses do not generally develop ...
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Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection.
... expression of IFN-c protein following ex vivo stimulation. Thompson et al. also studied the involvement of CAT2 in the immune response to the Th2-stimulating helminth Schistosoma mansoni and observed a similar increase ...
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Strategies of the African Swine Fever Virus to manipulate innate immunity
... The intracellular signal transduction pathways responsible for expression of the multiple cytokines and chemokines released during viral infection, are activated as a consequence of pathogen recognition receptor (PRR) ...
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