Kallikrein-kinin system
Towards understanding the kallikrein-kinin system: insights from measurement of kinin peptides
... The kallikrein-kinin system is complex, with several bioactive pep- tides that are formed in many different ...compartments. Kinin peptides are implicated in many physiological and ...
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Molecular biology of the kallikrein-kinin system: from structure to function
... the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effec- tive peptides kinins, in some pathological processes like hypertension and ...
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Correction: Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment.
... Itani, Wassim Abou-Kheir, Georges Daoud, Rui Zhu, Yehia Mechref, Jihane Soueid, Moustafa Al Hariri, Stefania Mondello, Ayad A.. Jaffa, Firas Kobeissy.[r] ...
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Cardioprotective effect of ornitho-kinin in an anesthetized, open-chest chicken model of acute coronary occlusion
... The kallikrein-kinin system (KKS) consists of a phylo- genetically ancient cascade that includes substrates (kinin- ogens), proteases (kallikreins), biologically active peptides (kinins), ...
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Kallikrein-like amidase activity in renal ischemia and reperfusion
... a kallikrein-like amidase activity probably related to the kallikrein-kinin system, as well as the participation of leukocyte infiltration in renal ischemia and ...in kallikrein-like ...
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Bradykinin Release Avoids High Molecular Weight Kininogen Endocytosis
... plasma kallikrein or other proteases to form its cleaved form without bradykinin, membrane tropomyosin also functions as a binding site uniquely for the bradykinin-free H-kininogen ...plasma ...
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Preclinical characterization of recombinant human tissue kallikrein-1 as a novel treatment for type 2 diabetes mellitus.
... the kallikrein-kinin system (KKS) has been shown to have beneficial effects on glucose homeostasis and several other physiological responses relevant to the progression of type 2 diabetes mellitus ...
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Role of vascular Kinin B-1 and B-2 receptors in endothelial nitric oxide metabolism
... lacking kinin receptors has allowed a better understanding of the physiological and pathological role of the kallikrein–kinin system in a wide range of biological events ...
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Ecotin-Like ISP of L. major Promastigotes Fine-Tunes Macrophage Phagocytosis by Limiting the Pericellular Release of Bradykinin from Surface-Bound Kininogens: A Survival Strategy Based on the Silencing of Proinflammatory G-Protein Coupled Kinin B-2 and B-
... Copyright © 2014 Erik Svensj¨o et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
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Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells.
... Tissue kallikrein (KLK1) expression is up-regulated in human diabetic kidney tissue and induced by high glucose (HG) in human proximal tubular epithelial cells ...the kallikrein-kinin system ...
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Regulation of the kinin receptors after induction of myocardial infarction: a mini-review
... vasoactive kinin peptides are mediated through the activation of two receptors termed bradykinin receptor B1 (B1R) and B2 ...of kinin metabolites has emerged as an important subject of investigation within ...
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Portal hypertensive response to kinin
... the kallikrein-kinin system, the role of bradykinin in the development of disease, and our main findings regarding the role of this nonapeptide in normal and experimental models of hepatic injury ...
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Glycosaminoglycans affect the interaction of human plasma kallikrein with plasminogen, factor XII and inhibitors
... plasma kallikrein, a serine proteinase, plays a key role in intrinsic blood clotting, in the kallikrein-kinin system, and in fibrin- ...on kallikrein activity on plas- minogen and ...
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Amelioration of cardiac function and activation of anti-inflammatory vasoactive peptides expression in the rat myocardium by low level laser therapy.
... Angiotensin System (RAS) and Kallikrein-Kinin System (KKS) vasoactive peptides was also ...of kinin B2 receptors and the circulating levels of plasma kallikrein compared to ...
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Altered Glucose Homeostasis and Hepatic Function in Obese Mice Deficient for Both Kinin Receptor Genes
... The Kallikrein-Kinin System (KKS) has been implicated in several aspects of metabolism, including the regulation of glucose homeostasis and ...this system and promote their effects by binding ...
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Kinin-B2 Receptor Mediated Neuroprotection after NMDA Excitotoxicity Is Reversed in the Presence of Kinin-B1 Receptor Agonists
... pathways. Kallikrein, an enzyme which releases brady- kinin (BK) and kallidin (Lys-BK) after proteolytic cleavage of kininogens, was already shown to participate in neuroprotective effects in ...vitro. ...
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Evidence for the presence of a kininogen-like species in a case of total deficiency of low and high molecular weight kininogens
... tected kinin in normal plasma with HK cleaved at its COOH-terminus, which has a higher electrophoretic mobility than intact, purified HK, and kinin in Williams ...
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Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus
... Amplification System with an ABI PRISMH 7000 Sequence Detection System (Applied Biosystems, Foster City, CA, ...for kinin B1 and B2 receptors, IL1b and TNFa, whereas 100 ng of cDNA was used for ...
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Rhodnius prolixus Malpighian tubules and control of diuresis by neurohormones
... The mechanism of MTs action is attractive from the physiological point of view for two main reasons. The first and more important one is that, during diure- sis, these tubules can transport fluids at a very high rate. ...
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