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Monoclonal antibodies

P roduction and characterization of monoclonal antibodies against Campylobacter fetus subsp. venerealis

P roduction and characterization of monoclonal antibodies against Campylobacter fetus subsp. venerealis

... Isotype characterization of monoclonal antibodies. The isotype characterization (classes and subclasses) of the produced MAbs were determined by ELISA as described (Harlow & Lane 1988). Briely, after ...

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Advances and challenges in therapeutic monoclonal antibodies drug development

Advances and challenges in therapeutic monoclonal antibodies drug development

... anti-drug antibodies (ADA) without any clinical relevance to serious effects including anaphylaxis and premature drug clearance interfering in the drug PK properties (Chirmule, Jawa, Meibohm, 2012), the ...

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ON THE NOTION OF SYNERGY OF MONOCLONAL ANTIBODIES AS DRUGS

ON THE NOTION OF SYNERGY OF MONOCLONAL ANTIBODIES AS DRUGS

... antitumor antibodies, at that stage still polyclonal ...when monoclonal antibodies (mAbs) to epidermal growth factor receptor (EGFR) were injected together with cisplatin [5] they exerted a strong ...

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Expression of Class 5 Antigens by Meningococcal Strains Obtained From Patients in Brazil and Evaluation of Two New Monoclonal Antibodies

Expression of Class 5 Antigens by Meningococcal Strains Obtained From Patients in Brazil and Evaluation of Two New Monoclonal Antibodies

... intraperitoneally and intravenously, 3 days before fusion. Hybridomas were expanded and cultured in the peritoneal cavities of Pristane-primed mice to obtain ascitic fluid. All procedures with animals were in accordance ...

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Production and characterization of monoclonal antibodies to a Brazilian bovine herpesvirus type 5

Production and characterization of monoclonal antibodies to a Brazilian bovine herpesvirus type 5

... for antibodies with virus-neu- tralizing activity ...BHV-5 monoclonal antibodies (mAbs) are unable to distinguish between these two viruses ...

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Production and Characterization of Monoclonal Antibodies Anti Fragment Fc of Bovine IgG

Production and Characterization of Monoclonal Antibodies Anti Fragment Fc of Bovine IgG

... and quantify the immunoglobulins, which are the main components of the system that detects invaders in solutions of biological fluids or associated cells of this same medium. The bovine immunoglobulins consist of four ...

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Investigation of rabies virus strains in Mexico with a panel of monoclonal antibodies used to classify Lyssavirus

Investigation of rabies virus strains in Mexico with a panel of monoclonal antibodies used to classify Lyssavirus

... Use of hybridoma monoclonal antibodies in the detection of antigenic differences be- tween rabies and rabies related virus pro- teins: I, the nucleocapsid protein.[r] ...

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Polysaccharide specific monoclonal antibodies provide passive protection against intranasal challenge with Burkholderia pseudomallei.

Polysaccharide specific monoclonal antibodies provide passive protection against intranasal challenge with Burkholderia pseudomallei.

... Burkholderia pseudomallei is a Gram-negative bacillus that is the causative agent of melioidosis. The bacterium is inherently resistant to many antibiotics and mortality rates remain high in endemic areas. The ...

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Isolation of highly active monoclonal antibodies against multiresistant gram-positive bacteria.

Isolation of highly active monoclonal antibodies against multiresistant gram-positive bacteria.

... human monoclonal antibodies was isolated from a healthy individual by selection of B- cells producing antibodies with high opsonic killing against ...tested. Monoclonal antibodies were ...

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Trypanosoma cruzi: amastigote polymorphism defined by monoclonal antibodies

Trypanosoma cruzi: amastigote polymorphism defined by monoclonal antibodies

... raised monoclonal antibodies (mAbs) directed towards amastigote forms of Trypanosoma cruzi, and shown that mAbs 1D9 and 4B9 are carbohydrate while mAb 4B5 activity is resistant to periodate oxidation of the ...

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Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model.

Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model.

... TcdB monoclonal antibodies were generated and their protective potency was character- ized in a hamster infection ...CANmAbB1) antibodies showed broad spectrum in vitro neutralization of toxins from ...

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Production and Characterization of Monoclonal Antibodies against Human Nuclear Protein FAM76B.

Production and Characterization of Monoclonal Antibodies against Human Nuclear Protein FAM76B.

... About 20% of proteins produced by the human genome contain single amino acid repeats, among which histidine (His) repeats are uncommonly seen with only 86 proteins bearing stretches of five or more consecutive histidine ...

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Detection of B. anthracis spores and vegetative cells with the same monoclonal antibodies.

Detection of B. anthracis spores and vegetative cells with the same monoclonal antibodies.

... Bacillus anthracis, the causative agent of anthrax disease, could be used as a biothreat reagent. It is vital to develop a rapid, convenient method to detect B. anthracis. In the current study, three high affinity and ...

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Computational prediction of neutralization epitopes targeted by human anti-V3 HIV monoclonal antibodies.

Computational prediction of neutralization epitopes targeted by human anti-V3 HIV monoclonal antibodies.

... V3-loop monoclonal antibodies (mAbs), 2219 [18] and 447-52D [19], and used this method in one of its useful applications: to obtain new calculated measurements of breadth of reactivity of these mAbs among ...

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Monoclonal antibodies to identify Tomato mosaic tobamovirus (ToMV)

Monoclonal antibodies to identify Tomato mosaic tobamovirus (ToMV)

... uniform monoclonal antibodies (MAb) suitable for plant virus diagnosis ...selecting monoclonal antibodies to recognize specific ToMV ...

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Characterization of gp70 and anti-gp70 monoclonal antibodies in Paracoccidioides brasiliensis pathogenesis

Characterization of gp70 and anti-gp70 monoclonal antibodies in Paracoccidioides brasiliensis pathogenesis

... produced monoclonal antibodies (MAbs) against gp70 to isolate the molecule from total fungus extracts and to investigate its possible role in the pathogenesis of ...

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Pharmacokinetics and immunogenicity of broadly neutralizing HIV monoclonal antibodies in macaques.

Pharmacokinetics and immunogenicity of broadly neutralizing HIV monoclonal antibodies in macaques.

... anti-idiotypic antibodies were directed to either the TARDY inser- tion in the CDRH3 region and/or the 6-amino acid changes in the CDR1 and ...anti-PGT121 antibodies, plasma from animals injected twice with ...

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Monoclonal Antibodies for Multiple Sclerosis Treatment

Monoclonal Antibodies for Multiple Sclerosis Treatment

... membrane antibodies during safety follow-up and another patient was diagnosed with presumed autoimmune pancytopenia 19 months after his last alemtuzumab ...

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Preparation of monoclonal antibodies against gamma-type phospholipase A

Preparation of monoclonal antibodies against gamma-type phospholipase A

... of monoclonal antibody prepar- ation is time-consuming and laborious; the resulted mAbs are generally high ...Protein-specific antibodies can be generated by immunization of animals with peptides, if the ...

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An alternative chemical redox method for the production of bispecific antibodies: implication in rapid detection of food borne pathogens.

An alternative chemical redox method for the production of bispecific antibodies: implication in rapid detection of food borne pathogens.

... polyclonals antibodies (data not shown for b–mercaptoethanol). The monoclonal antibodies were reduced by adding an equal volume of two fold concentrated b- mercaptoethanesulphonic acid sodium salt ...

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