Multidrug resistance (MDR)
Expression of P-glycoprotein, multidrug resistance-associated protein, glutathione-S-transferase pi and p53 in canine transmissible venereal tumor
... of multidrug resistance (MDR) (Di Pietro et ...cross resistance to seve- ral other compounds unrelated structurally or functionally (Thomas & Coley ...Drug resistance may be related to ...
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The master activator of IncA/C conjugative plasmids stimulates genomic islands and multidrug resistance dissemination.
... Schematic representation of SGI1 from S. enterica Typhimurium DT104 and MGIVmi1 from V. mimicus VM573. The left and right junctions (attL and attR) within the host chromosome are indicated. SGI1 (42 596 bp, Genbank ...
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The Nucleotide-Free State of the Multidrug Resistance ABC Transporter LmrA: Sulfhydryl Cross-Linking Supports a Constant Contact, Head-to-Tail Configuration of the Nucleotide-Binding Domains.
... ABC transporters are integral membrane pumps that are responsible for the import or export of a diverse range of molecules across cell membranes. ABC transporters have been impli- cated in many phenomena of medical ...
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Antineoplastic therapy - multidrug resistance
... Multidrug resistance (MDR) in oncology stand as one of the main challenges in clinical treatment, as a result of several concomitant yet different mechanisms developed by carcinoma stem cells ...multiple ...
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P-glycoprotein and multidrug resistance: structure-activity relationships of modulators.
... AND MULTIDRUG RESISTANCE: STRUCTURE-ACTIVITY RELATIONSHIPS OF ...MODULATORS. Multidrug resistance, MDR is a major obstacle for cancer ...
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NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance.
... of resistance to chemotherapy [2]. The inevitable development of multidrug resistant cancer cells during the course of treatment is a major fundamental obstacle associated with cancer ...cross ...
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Modulation of P-Glycoprotein Mediated Multidrug Resistance (Mdr) in Cancer Using Chemosensitizers.
... of resistance to a wide spectrum of drugs occurred through a variety of ...of multidrug resistance ...drug resistance, the best-studied mechanism of MDR is related to the over expression of ...
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Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistance.
... Multidrug resistance (MDR) is a major impediment to curative cancer ...mitoxantrone resistance due to its dramatic sequestration in ...level resistance to topotecan, imidazoacridinones and ...
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Increased JNK1 signaling pathway is responsible for ABCG2-mediated multidrug resistance in human colon cancer.
... Multidrug resistance remains a major obstacle to effective chemotherapy of colon ...drug resistance of colon cancer is unclear and scarcely ...ABCG2-induced multidrug resistance in ...
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Integron mediated multidrug resistance in extended spectrum beta-lactamase producing clinical isolates of Klebsiella pneumoniae
... not resistance genes are contained within the integrons, the results presented here indicate wide dissemination of ARIs in ESBL producing ...drug resistance rates as well as multidrug resis- ...
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The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans.
... of resistance to the widely used antifungal agent fluconazole in clinical ...azole resistance in certain clinical strains, led Coste et ...drug resistance in many clinical ...drug resistance. A ...
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Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa
... unknown. Multidrug-resistance protein (MRP)–like adenosine triphosphate (ATP)–binding cassette transporters are known to be related to multidrug resistance in many ...
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Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus
... In this study, we aimed to highlight the relationship between efflux and mutation(s) throughout the process of emergence of resistance in S. aureus, by exposing a set of representative MSSA and MRSA strains to ...
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Rev. bras. farmacogn. vol.21 número5
... Abstract: Multidrug resistance of cancer cells and pathogenic microorganisms leading to the treatment failure of some forms of cancer or life-threatening bacterial or fungal infections is often caused by ...
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The Age of Multidrug Resistance: Ten Year Incidence in a Neonatal Intensive Care Unit
... No entanto, ao comparar a taxa de letalidade por BMR (10,9%) calculada no presente estudo com a taxa de mortalidade global (4,4%) e com a taxa de letalidade por infeções assoc[r] ...
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Pharmacogenetic analysis of the pregnane x receptor in breast cancer. Case-control study
... One of the most common treatments for cancer is chemotherapy. However, due to multidrug resistant cancer cells, the efficiency of this treatment is narrow or limited. However drug metabolizing enzymes (DMEs) and ...
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The role of the efflux mechanisms in multidrug resistance in Mycobacterium tuberculosis
... capreomycin. Resistance in Mycobacterium tuberculosis is mainly due to the occurrence of spontaneous mutations and followed by selection of mutants by subsequent ...with resistance to a given antibiotic, ...
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Positive Epistasis Drives the Acquisition of Multidrug Resistance
... antibiotic resistance but also reveal an extra layer of complexity on epistatic patterns previously unpredicted, since it is hidden in genome-wide studies of genetic interactions using gene ...antibiotic ...
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Sao Paulo Med. J. vol.126 número3
... the multidrug resistance-associated protein 1 (MRP1) gene has been linked with resistance to chemotherapy in vitro, but little is known about its clinical impact on acute leukemia ...
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MULTIDRUG EFFLUX SYSTEMS IN GRAM-NEGATIVE BACTERIA Maria Aparecida Scatamburlo Moreira1 ; Edmar Chartone de Souza2 ; Célia Alencar de Moraes1
... characterized multidrug efflux pump may be the Permease-glycoprotein (P-glycoprotein), encoded by the mdr1 gene (multidrug resistance), identified in humans and in rodents, which is responsible for ...
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