NADPH oxidase
Bacillus calmette-guerin infection in NADPH oxidase deficiency: defective mycobacterial sequestration and granuloma formation.
... Taken together, the results presented here not only shed new light on BCG infection in CGD, but also provide first evidence for a role of the macrophage NADPH oxidase in the coordination of granuloma ...
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Desbalanço redox: NADPH oxidase como um alvo terapêutico no manejo cardiovascular.
... da NADPH oxidase é a maior fonte dessas espécies reativas na ...da NADPH oxidase e predomínio de agentes pró-oxidantes, superando a capacidade de defesa orgânica ...a NADPH ...
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Efeitos antiinflamatórios e do fitol, um ativador de NADPH oxidase, e tadalafil, um inibidor de 5, em modelos experimentais
... while cartilage glycosaminoglycans (GAGs) were quantified after 7 d of ZyA in rats. Results were expressed as mean ± SEM, submitted to ANOVA and Tukey test or to Student’s t test (P <0.05). In writhing, data were ...
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Signal Transduction and Activation of the NADPH Oxidase in Eosinophils
... The LTB 4 -, C5a- and fMLP-stimulated re- sponses are thought to activate eosinophils via in- tercalation with receptors linked to the pertussis toxin sensitive G-protein, G i (Kita et al. 1991, Miyamasu et al. 1995, ...
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Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism.
... specific NADPH oxidase inhibitor GKT136901 was identified by screening more than 130,000 molecules ...xanthine oxidase (Ki = 50 ...inhibits oxidase activity of NOX1 and NOX4 but has only a ...
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Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension
... xanthine oxidase activity inhibition. Conversely, nitrite decreased vascular NADPH oxidase ...vascular NADPH oxidase activity ...
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Apocinina e metóxi-catecóis correlatos: relação entre estrutura molecular e inibição da ativação do complexo NADPH oxidase
... and its mechanism of action involves the impairment of the assemble process of the enzyme. Here, we studied the structure-activity relationship for apocynin and analogous ortho-methoxy-substituted catechols as inhibitors ...
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Tobacco Smoke Induces Ventricular Remodeling Associated with an Increase in NADPH Oxidase Activity
... (NADPH) oxidase complex (Nox family NADPH oxidases) are the main cellular and vascular source of ROS with purposes of compartment- specific redox signaling ...[5]. NADPH oxidases are highly ...
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Estudo da relação entre estrutura química e atividade biológica de inibidores de NADPH Oxidase em leucócitos: relevância da oxidabilidade e hidrofobicidade
... complex NADPH oxidase is one of the most important components in this context because it is a major source of superoxide anion in animal ...complex NADPH oxidase and compare its efficacy with ...
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Oleic, Linoleic and Linolenic Acids Increase ROS Production by Fibroblasts via NADPH Oxidase Activation
... activate NADPH oxidase in leukocytes [15] and pancreatic b cells [16], the effect of oleic, linoleic and c-linolenic acids on NADPH oxidase in fibroblasts has not yet been ...
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Contribuição do complexo enzimático NADPH oxidase na atrofia muscular de ratos infartados:...
... Uma parte dos animas de ambos os grupos (Infartados e Sham) foram submetidos ao tratamento com apocinina com o intuito de inibir a NADPH oxidase e estudar a contribuição deste complexo na atrofia muscular e ...
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Sistema enzimático gerador de peróxido de hidrogênio: NADPH oxidase na tireóide humana.
... Superoxide anion is the initial product in the hydrogen peroxide formation catalyzed by NADPH-oxidase in the porcine thyroid plasma membrane.. Nakamura Y, Makino R, Tanaka T, Ishimura Y,[r] ...
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Mechanisms for suppressing NADPH oxidase in the vascular wall
... NADPH oxidase to form a radical, which then forms cova- lent adducts with the flavin cofactor (FAD), resulting in a shunt of the electron to molecular oxygen (O’Donnell et ...of NADPH oxidase ...
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Eixo IL-12/23-IFN-g e o sistema NADPH oxidase
... da NADPH oxidase no modelo de células B EBV foi o aumento da expressão espontânea e/ou estimulada por IFN-γ de alguns dos genes avaliados em determinadas ...
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Apocynin: Chemical and biophysical properties of a NADPH oxidase inhibitor
... Abstract: Apocynin is the most employed inhibitor of NADPH oxidase (NOX), a multienzymatic complex capable of catalyzing the one-electron reduction of molecular oxygen to the superoxide anion. Despite ...
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Expression of NADPH oxidase (NOX) 5 in rabbit corneal stromal cells.
... We have amplified the NOX5 gene product by RT- PCR, detected a NOX5 encoded protein by western blotting, measured superoxide production, silenced NOX5 using siRNA designed based on the s[r] ...
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Arq. Bras. Cardiol. vol.94 número5
... When human MPO is added, dimers may be identified in cells with superexpression of Nox isoforms or in cells co-incubated with H 2 O 2 . In absence of H 2 O 2 or Nox, dimer production by HEK293 cells is inhibited. In ...
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The endogenous nitric oxide mediates selenium-induced phytotoxicity by promoting ROS generation in Brassica rapa.
... for NADPH oxidase and the following ROS accumulation in roots, which further resulted in the amelioration of Se(IV)-induced oxidative injury and growth ...
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Streptococcus agalactiae in human endothelial cells
... is NADPH oxidase, an O 2 -generating enzyme also expressed in oth- er mammalian cell types (Li and Shah ...2003). NADPH oxidase activation (oxidative burst) is essential for im- mune responses ...
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Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation.
... Results: We now demonstrate that Angeli’s salt inhibits Ang II-induced hypertrophic responses in cardiomyocytes, including increases in cardiomyocyte size, de novo protein synthesis and b-myosin heavy chain expression. ...
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