Nuclear receptor
A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery.
... human nuclear receptor ligand-binding domain (LBD) and an affinity tag cassette ...of nuclear GFP is used to monitor receptor ligand sensor activity in a cell- and tissue autonomous manner in ...
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Regulation of adipogenesis by nuclear receptor PPAR g is modulated by the histone demethylase JMJD2C
... The nuclear receptor Peroxisome Proliferator-activated receptor gamma (PPARg) is the master regulator of adipose cell differentiation and its functional activation is currently used as a thera- ...
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Nuclear receptor 4a3 (nr4a3) regulates murine mast cell responses and granule content.
... Nuclear receptor 4a3 (Nr4a3) is a transcription factor implicated in various settings such as vascular biology and ...upregulate Nuclear receptor 4a3 upon activation, and here we investigated ...
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Diverse coactivator recruitment through differential PPAR g nuclear receptor agonism
... PPARg nuclear receptor regulates the expression of genes involved in lipid and carbohydrate metabolism, and it has protective effects in some patients with type 2 ...clear receptor protein is limited ...
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Computational characterization of modes of transcriptional regulation of nuclear receptor genes.
... that nuclear receptor genes separated into two major clusters on the basis of different enrichment of various chromatin states (Figure ...level, nuclear receptors have broadly separated into two ...
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Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development.
... Our ring gland microarray and qPCR data revealed that Cyp6t3 transcript levels are significantly elevated in hsDHR4 RNAi animals and DHR4 1 mutants. In addition, we showed that Cyp6t3 expression levels oscillate during ...
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Dissecting the Relation between a nuclear receptor and GATA: binding affinity studies of thyroid hormone receptor and GATA2 on TSHβ promoter.
... The study of the TR-GATA2 complex on DNA is particularly attractive because it is potentially the primary complex assembled on the TSHb promoter triggered by T3 binding to TR. In addition, the interaction of GATA2 with ...
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Regulation of Nuclear Receptor Nur77 by miR-124.
... The nuclear receptor Nur77 is commonly upregulated in adult cancers and has oncogenic functions. Nur77 is an immediate-early response gene that acts as a transcription factor to promote proliferation and ...
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Small Heterodimer Partner and Innate Immune Regulation
... The nuclear receptor superfamily consists of the steroid and non-steroid hormone receptors and the orphan nuclear ...family nuclear receptor that plays an essential role in the ...
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Overexpression of retinal degeneration slow (RDS) protein adversely affects rods in the rd7 model of enhanced S-cone syndrome.
... The nuclear receptor NR2E3 promotes expression of rod photoreceptor genes while repressing cone genes. Mice lacking NR2E3 (Nr2e3 rd7/rd7 referred to here as rd7) are a model for enhanced S-cone syndrome, a ...
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Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17.
... IGF-1 nuclear IGF-1R also translocates from the cell surface ...the nuclear IGF-1R is not synthesized de novo, since cycloheximide fails to block nuclear accumulation of the receptor provoked ...
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Effects of IL-10 and glucose on expression of OPG and RANKL in human periodontal ligament fibroblasts
... The effects of interleukin-10 (IL-10) and glucose on mRNA and protein expression of osteoprotegerin (OPG), and its ligand, receptor activator of nuclear factor-kB ligand (RANKL), were investigated in human ...
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Clinics vol.72 número4
... RUNX-2, receptor activator of nuclear factor-kB ligand (RANKL), osteoprotegerin (OPG) (Applied Biosystems, Foster City, CA, USA), and tartrate-resistant acid phosphatase (TRAP) in the bones of control and ...
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Braz. J. Phys. vol.36 número4B
... on Nuclear Physics in Brazil took place in Guaruja, SP, Brazil, from 7-11 Sep- tember 2005, with 151 ...of Nuclear Reactions, Nuclear Structure, Nuclear Matter at High Energy Densities, ...
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J. Appl. Oral Sci. vol.23 número1
... 4- Bai XC, Lu D, Liu AL, Zhang ZM, Li XM, Zou ZP, et al. Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast. J Biol Chem. 2005;280:17497-506. 5- Baltacioglu E, ...
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Modifier genes as therapeutics: the nuclear hormone receptor Rev Erb alpha (Nr1d1) rescues Nr2e3 associated retinal disease.
... the nuclear hormone receptor family; namely the highly variable A/B domain, N terminal DNA binding domain, a flexible hinge region and the ligand-binding and dimerization domain in the C terminus ...
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Strong Nuclear Gravitational Constant and the Origin of Nuclear Planck Scale
... attempts have been done in physics history [1–5]. Whether it may be real or an equivalent if it is existing as a “single constant” its physical significance can be understood. “Nu- clear size” can be fitted with ...
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Cálcio intracelular na proliferação de células hepáticas
... and nuclear translocation of thioredoxin 1 (TRX1), where it interacts with redox factor 1 (Ref1) to modulate the DNA-binding activity of the activator protein 1 (AP-1) transcription factor complex [9] ...
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Components and regulation of nuclear transport processes
... inner nuclear membrane that are 30 nm apart. The nuclear envelope (NE) provides a much stronger physical bar- rier than the single cordon of the plasma ...outer nuclear membrane is continuous with ...
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Arq. NeuroPsiquiatr. vol.69 número5
... All but two patients with global aphasia had large le- sions in the left MCA territory, for this was the lesion site that afected most language functions. On the other hand, all cases of lone cortical dysarthria were ...
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