Post-Translational
Asymmetric post-translational modifications regulate the intracellular distribution of unstimulated STAT3 dimers
... Asymmetric post-translational modifications change the intracellular distribution of STAT3 homodimers more strikingly than symmetric ...by post- translational modifications beyond ...
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Scanning MscL Channels with Targeted Post-Translational Modifications for Functional Alterations.
... E . coli giant spheroplasts were generated and used in patch-clamp experiments as described previously [13]. Excised, inside-out patches were examined at room temperature under sym- metrical conditions using a buffer ...
23
Post-translational modifications modulate ligand recognition by the third PDZ domain of the MAGUK protein PSD-95.
... and post-translational modifications, the latter of which is the most efficient method of accelerating cellular responses to environmental changes in ...succinimidation post-translational ...
11
Schistosoma mansoni encodes SMT3B and SMT3C molecules responsible for post-translational modification of cellular proteins.
... The sumoylation pathway is a post-translational modification of nuclear proteins widespread among several organisms. SMT3C is the main protein involved in this process and it is covalently conjugated to a ...
7
Overlooked post-translational modifications of proteins in Plasmodium falciparum: N- and O-glycosylation - A review
... The presence of O-glycosylation in MSP from P. fal- ciparum remains controversial. Nasir-ud-Din et al. (1992) observed that MSP-1 was modified by O-GlcNAc. Later, Khan et al. (1997) concluded that MSP-2 was O-glycosy- ...
8
Assigning quantitative function to post-translational modifications reveals multiple sites of phosphorylation that tune yeast pheromone signaling output.
... For the redundant repressor protein Dig1, we utilized a sensitized genetic background in which CFP-tagged Ste12 requires Dig1 for its full activity to increase the likelihood of revealing functional roles for Dig1 ...
11
Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.
... The development of high-throughput measurement technologies, such as mass spectrometry based proteomics, has led to a rapid expansion in the discovery of post-translational modifica- tions (PTMs) [1]. In ...
14
Expression of STEAP1 and STEAP1B in prostate cell lines, and the putative regulation of STEAP1 by post-transcriptional and post-translational mechanisms
... acid post-translational alterations such as N-glycosylation, N-Glycation, Phosphorylation and Phosphokinase specific sites, and addition sites of O-linked β-N-acetylglucosamine (O-β- GlcNAc) were carried ...
10
Coupling of a core post-translational pacemaker to a slave transcription/translation feedback loop in a circadian system.
... Cyanobacteria are the only model circadian clock system in which a circadian oscillator can be reconstituted in vitro. The underlying circadian mechanism appears to comprise two subcomponents: a ...
16
The role of post-translational modifications on STAT3 interactions
... The Venus-STAT3 bimolecular fluorescence complementation (BiFC) assay was designed by Ana Maia Rocha (MSc) and optimized by Catarina Almeida (MSc) at our laboratory (Cell Structure and Dynamics, ITQB-NOVA, Oeiras, ...
71
Prediction of the post-translational modifications of adipokinetic hormone receptors from solitary to eusocial bees
... the post-translational modifications, the eusocial possessed more phosphorylation residues and modification patterns, which might be due to the necessity of more diverse ...on post- ...
9
Identification and characterization of HTLV-1 HBZ post-translational modifications.
... Human T-cell leukemia virus type-1 (HTLV-1) is estimated to infect 15–25 million people worldwide, with several areas including southern Japan and the Caribbean basin being endemic. The virus is the etiological agent of ...
10
Histone post-translational modifications and chromatin remodelers in colorectal cancer
... Histone methylation is other most frequent post-translational modification that occurs both on lysine and arginine residues of the N-terminal tail of histones. Like histone acetylation, histone methylation ...
25
Post-translational regulation of Oct4 transcriptional activity.
... In NIH 3T3 cells transfected with PORE reporter and Oct4 expression constructs, overnight treatment with N 6 -Bnz- cAMP elicited a response , 50% of that obtained by treatment with 8-Br-[r] ...
9
Characterizing HSF1 Binding and Post-Translational Modifications of hsp70 Promoter in Cultured Cortical Neurons: Implications in the Heat-Shock Response.
... The amount of Hsp70 protein increased in the three cell types in response to heat shock, even though the data confirm that the increment of Hsp70 in cells with neuronal phenotype, such a[r] ...
16
Novel Antimicrobial Peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the Edible Sea Urchin Echinus esculentus Have 6-Br-Trp Post-Translational Modifications.
... The global problem of microbial resistance to antibiotics has resulted in an urgent need to develop new antimicrobial agents. Natural antimicrobial peptides are considered promising candidates for drug development. ...
25
Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel.
... It appears that modification of toxins is widespread, having been found especially in conotoxins, and Conus venom peptides are proving to be among the most highly post-translationally modified gene products known ...
8
Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells.
... We then confronted these functional data with the quantification of CFTR protein amount: N-WASP depletion resulted in only a small decrease, while Cdc42 indeed elicited a 37% in- crease of total CFTR amount (Fig. 8A and ...
23
Discovery of novel biomarkers in gastric cancer based on post-translational modifications of glycoproteins
... 1) We have developed a glycoproteomic approach that specifically detected cancer associated truncated O-glycans in serum glycoproteins from patients with percursor lesions of[r] ...
266
Expression of histone modifying enzymes and histone post-translational marks in colorectal cancer
... 29 using the Novolink TM Polymer Detection System ( Novocastra , Newcastle, UK) . Briefly, tissue sections of 3 µm in thickness were cut from each paraffin block. Deparaffinized tissue sections were submitted to antigen ...
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