Receptor, Epidermal Growth Factor
The Inflammasome and the Epidermal Growth Factor Receptor (EGFR) Are Involved in the Staphylococcus aureus-Mediated Induction of IL-1alpha and IL-1beta in Human Keratinocytes.
... IL-1 receptor, play an important role in cutaneous defense against ...the epidermal growth factor receptor (EGFR) often suffer from skin infections caused by ...
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Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.
... the receptor tyrosine kinase-mediated angio- genesis in head neck squamous cell carcinoma ...The receptor tyrosine kinase activity in a transgenic mouse model of HNSCC was ...cetuximab-induced ...
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Internalization mechanisms of the epidermal growth factor receptor after activation with different ligands.
... The epidermal growth factor receptor (EGFR) regulates normal growth and differentiation, but dysregulation of the receptor or one of the EGFR ligands is involved in the ...
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Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival
... Epidermal growth factor inhibitors, antibodies and other molecules, such as erlotinib, gefitinib, cetuximab, panitumumab, trastuzumab and lapatinib, have been used in the treatment of colorectal, ...
9
Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data
... Lung cancer leads cancer-related mortality worldwide. Non-small-cell lung cancer (NSCLC), the most prevalent subtype of this recalcitrant cancer, is usually diagnosed at advanced stages, and available systemic therapies ...
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Baseline and Trend of Lymphocyte-to-Monocyte Ratio as Prognostic Factors in Epidermal Growth Factor Receptor Mutant Non-Small Cell Lung Cancer Patients Treated with First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.
... Patients with early-stage lung cancer who have a high baseline lymphocyte-to-monocyte ratio (LMR) have a favorable prognosis. However, the prognostic significance of LMR in patients with advanced-stage EGFR-mutant ...
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Coarse-grained molecular simulation of epidermal growth factor receptor protein tyrosine kinase multi-site self-phosphorylation.
... the epidermal growth factor receptor (EGFR), the intrinsic protein tyrosine kinase (PTK) activity of one receptor monomer is activated, and the dimeric receptor undergoes ...
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Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling
... EGF receptor, NO decreased the phosphorylation status of this receptor, possibly by inhibiting the tyrosine kinase activity of EGFR, which has over 15 tyro- sine residues that can be phosphorylated and ...
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Gefitinib induces epidermal growth factor receptor dimers which alters the interaction characteristics with ¹²⁵I-EGF.
... Interaction Maps, depicts a reality where EGF interacts with not only one receptor form, but several. The different receptor populations may be the monomeric, heterodimeric and homodimeric form of EGFR. The ...
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Systems biology modeling reveals a possible mechanism of the tumor cell death upon oncogene inactivation in EGFR addicted cancers.
... of epidermal growth factor receptor (EGFR) associated signaling network, which involves EGFR-driving proliferation/pro-survival signaling pathways Ras/extracellular-signal-regulated kinase ...
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J. Pneumologia vol.28 número3
... treatment modalities, targeting the tumor cell biological cycle. In this article, the authors review the role of some of the traditionally known tumor markers ( CEA , p53, NSE , K-ras), and describe the prevalence and ...
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ON THE NOTION OF SYNERGY OF MONOCLONAL ANTIBODIES AS DRUGS
... to epidermal growth factor receptor (EGFR) were injected together with cisplatin [5] they exerted a strong synergistic effect on the ability to reduce the size of tumors (KB human ...
3
A novel classification of lung cancer into molecular subtypes.
... Lung cancer kills more patients than any other malignancy in the world [1]. Early-stage disease can be treated with curative intent although the risk for relapse is notoriously high. Unfortu- nately, the majority of lung ...
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Arq Bras Endocrinol Metab vol.51 número4
... The multichaperone heat shock protein (Hsp) 90 complex mediates the maturation and stability of a variety of proteins, many of which are crucial in oncogenesis, including epidermal growth factor ...
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Analysis of EGFR overexpression, EGFR gene amplification and the EGFRvIII mutation in Portuguese high-grade gliomas
... therapy. Epidermal growth factor receptor (EGFR) controls several oncogenic processes, being frequently up-regulated in gliomas due to overexpression, gene amplification and gene ...
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Sao Paulo Med. J. vol.129 número6
... CONTEXT AND OBJECTIVE: Cyclooxygenase-2 (COX-2) and human epidermal growth factor receptor type 2 (HER-2) are associated with tumorigenesis. Studies have shown that HER-2 can regulate COX-2 ...
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Identification of potent EGFR inhibitors from TCM Database@Taiwan.
... Overexpression of epidermal growth factor receptor (EGFR) has been associated with cancer. Targeted inhibition of the EGFR pathway has been shown to limit proliferation of cancerous cells. ...
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Clinics vol.67 número5
... Epidermal growth factor receptor (EGFR) is critically involved in NSCLC pathogenesis and has recently emerged as an important target for molecular ...
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Braz. Dent. J. vol.23 número4
... protein, epidermal growth factor receptor (EGFR) and Notch-1 in the epithelial lining of radicular cysts (RC), dentigerous cysts (DC) and keratocystic odontogenic tumors ...
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Transgenic Soybean Production of Bioactive Human Epidermal Growth Factor (EGF).
... of epidermal growth factor (EGF), which is necessary for normal intestinal development and repair ...critical growth factor found in multiple fluids that bathe the developing intestine ...
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