STELLATE CELLS
HIV and HCV Co-Culture Promotes Profibrogenic Gene Expression through an Epimorphin-Mediated ERK Signaling Pathway in Hepatic Stellate Cells.
... Accelerated fibrosis in patients co-infected with hepatitis C virus (HCV) and human immuno- deficiency virus (HIV) has been a major cause of mortality in the highly active anti-retroviral therapy (HAART) era. However, ...
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Gene expression profiling and secretome analysis differentiate adult-derived human liver stem/progenitor cells and human hepatic stellate cells.
... stem/progenitor cells (ADHLSC) are obtained after primary culture of the liver parenchymal ...The cells are of fibroblastic morphology and exhibit a hepato-mesenchymal ...Hepatic stellate ...
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The mechanism of abrupt transition between theta and hyper-excitable spiking activity in medial entorhinal cortex layer II stellate cells.
... Recent studies have shown that stellate cells (SCs) of the medial entorhinal cortex become hyper-excitable in animal models of temporal lobe epilepsy. These studies have also demonstrated the existence of ...
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Effect of curcumin on the proliferation and apoptosis of hepatic stellate cells
... liver disease and represents a major worldwide health care burden. Hepatic stellate cells (HSC) undergo activation into proliferative and fibrogenic myofibroblast-like cells during liver injury (1). ...
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Distribution of hepatic stellate cells and their role in the development of parasitic fibrosis and liver cirrhosis in domestic animals
... perisinusoid stellate cells and portal ibroblast, α-SMA, LSAB2; c) liver of a beef with the second level of ibrosis, connective tissue of septa spreading in the form of strips betweenthe lobule, HE ; d) ...
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The effect of down-regulation of Smad3 by RNAi on hepatic stellate cells and a carbon tetrachloride-induced rat model of hepatic fibrosis
... Searching for effective Smad3 gene-based gene therapies for hepatic fibrosis, we constructed siRNA expression plasmids targeting the rat Smad3 gene and then delivered these plasmids into hepatic stellate ...
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Development of gene therapy to deliver the receptor-specific rhTRAIL DHER variant to induce apoptosis in activated hepatic stellate cells for the treatment of liver fibrosis
... hepatic stellate cells (HSC), when they evolve from the quiescent state to an activated ...These cells express on their surface receptors for Tumor Necrosis Factor- Related Apoptosis Inducing Ligand ...
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Hepatic stellate cells secreted hepatocyte growth factor contributes to the chemoresistance of hepatocellular carcinoma.
... hepatic stellate cells (HSCs) have a great impact on biological behaviors of hepatocellular carcinoma ...Hep3B cells was enhanced with LX-2 CM (cultured medium) exposure in vitro as well as co- ...
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Carvedilol improves inflammatory response, oxidative stress and fibrosis in the alcoholinduced li injury in rats by regulating kuppfer cells and hepatic stellate cells
... positive cells; 2 = small number of positive cells or isolated cells; 3 = moderate number of positive cells; and 4 = large number of positive ...
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Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells.
... of cells derived from single CD34 – KSL cells were injected into the tail veins of irradiated ...radioprotective cells during the post-irradiation pancytopenia ...
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Inhibitory effect of tanshinone IIA on rat hepatic stellate cells.
... IIA. Cells were pretreated with Tan IIA (1, 3 or 10 m M) or Sal B (200 m M) for 30 min, and stimulated with LPS (100 ng/ml) for 6 ...normal cells. If cells are stimulated with diverse agents, p50/p65 ...
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Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3.
... As dsRNAs and Poly(I:C) are able to induce innate immune responses via alternative pathways from those triggered by TLR3 (e.g. RIG-1 and MDA5) we wished to confirm that the IFN and IL-6 responses we have described can be ...
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Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways.
... hepatic stellate cells, KITLG expression stimulated by IGF1R signaling may facilitate the KIT-dependent recruitment of inflammatory cells in injury and fibrosis [55] and progenitor cells in ...
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Clinics vol.63 número5
... myoibroblast cells post-BDL was higher in the young rats, reaching its peak value in a shorter time compared to the adult ...myoibroblast cells in young animals, which suggests that more extensive fibrosis ...
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NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development.
... Mice stellate cells, myofibroblasts and hepatocytes were obtained in our or colleagues’ laboratories and used in previous published works [14,18,19]: 1) By employing p19 ARF deficiency, we established a ...
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Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis.
... epithelial cells was observed in PINCH DKO mice, (Figure 5A). These cells were characterized as biliary by virtue of their morphology and the fact that their nuclei were staining positive for the ...
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Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites.
... basket cells occupy mainly the upper or lower half of the ML, ...of stellate and basket axons in their morphology and subcellular innervation pattern, even when they are found at the same location in the ...
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The chemokine CCL3 promotes experimental liver fibrosis in mice.
... hepatic stellate cells [30], we next stimulated these cells with recombinant CCL3 in ...on stellate cells, as determined by BrdU ...treated cells compared to control, confirming ...
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Schistosoma mansoni: Egg-induced downregulation of hepatic stellate cell activation and fibrogenesis
... Eggs of Schistosoma mansoni trapped in human liver can lead to fibrosis. Since liver fibrosis requires acti- vation of hepatic stellate cells (HSC) from a quiescent to a myofibroblastic phenotype, we ...
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Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture.
... these cells, PPARc, the top gene on this list (Table 1), has been reported to be a potent inducer of EMT in intestinal epithelial cells ...the stellate phenotype and has been implicated in migration ...
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