Telomere shortening
Constitutive OGG1 variant together with BRCA mutations display accelerated telomere shortening
... the telomere level it can impair the recruitment and affinity of the shelterin complex ...normal telomere function and length can result in carcinogenesis, as a consequence of genomic ...the telomere ...
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Telomere shortening impairs regeneration of the olfactory epithelium in response to injury but not under homeostatic conditions.
... whether telomere shortening had an influence on the regenerative response after Triton-X treatment, cross sections of the OE were analyzed 7 days after Triton-X induced OE ...that telomere ...
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Estresse oxidativo em Leishmania amazonensis = do encurtamento dos telômeros ao deslocamento de LaRPA-1 do complexo telomérico = Oxidative stress in Leishmania amazonensis : from telomere shortening to displacement of LaRPA-1 from telomeric complex
... 3.8 Extração de DNA genômico de L. amazonensis para ensaio Southern blot e telomere-PCR O DNA genômico foi extraído de parasitos, na forma promastigota, originados de culturas em fase exponencial de crescimento. ...
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Blood cell telomere length is a dynamic feature.
... accelerated telomere loss [31], is a common feature for a number of conditions where shorter telomeres have been found in patients compared to ...34]. Telomere related effects of oxidative stress might be ...
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Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.
... in telomere-driven replicative senescence challenged the simple idea that in telomerase-negative cells, the telomeres shorten progressively through failure of complete chromo- some-end ...that telomere ...
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Telomere Length in Peripheral Blood Leukocytes Is Associated with Severity of Biliary Atresia.
... ated telomere length in BA patients, but did not measure the activity of telomerase ...of telomere length relating to BA in these ...between telomere shortening and the severity of ...
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Lead Exposure Induces Telomere Instability in Human Cells.
... to telomere shortening, which has been shown to lead to cH2Ax foci formation in the absence of bona fide DSBs ...cells. Telomere shortening in somatic cells is a signal of replicative cell ...
8
Correlation of chromosomal instability, telomere length and telomere maintenance in microsatellite stable rectal cancer: a molecular subclass of rectal cancer.
... have telomere lengths 3000 to 5000 bp shorter than the telomeres of the adjacent normal colon epithelium in up to 75% of CRC cases ...featured telomere length longer than that of adjacent normal colon ...
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Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast.
... the telomere dysfunction phenotypes associated rpd3 mutants, it is of interest that many of the other mutants recovered in our telomere structure screen have been previously identified to have negative ...
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Telomere length modulation in human astroglial brain tumors.
... Our findings, are consistent with the hypothesis that in astroglial brain tumors, up-regulation of TRF1 and TRF2 may occur in the early stages of carcinogenesis when telomerase has not yet been activated or is ...
8
Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.
... Absence of active telomerase in mice resulted in progressive telomere shortening both in vivo and in vitro [5,6,26]. Short or dysfunctional telomeres produced massive chromosome/genomic instability in these ...
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Telomere biology of cutaneous T-Cell lymphomas
... telomeres. Telomere fragments are then resolved by agarose gel electrophoresis and detected by Southern blot using a labeled telomere ...average telomere length is determined by quantification of the ...
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Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer.
... of telomere length and telomerase activity, in relation to clinical variables, may shed light on colorectal cancer ...to telomere length and telomerase activity, previous results demonstrated that ...
12
Telomere fragment induced amnion cell senescence: a contributor to parturition?
... causing telomere shortening and sterile inflammation resulting in parturition ...the telomere-dependent mechanism of senescence and inflamma- tory ...of telomere fragments was higher in term ...
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Telomere length and childhood trauma in Colombians with depressive symptoms
... studies by Hoen et al. 31 and Verhoeven et al. 32 found no relationship between depression and telomere shortening. The discrepancies between these studies could be explained by the fact that they included ...
5
Telomere length and childhood trauma in Colombians with depressive symptoms
... studies by Hoen et al. 31 and Verhoeven et al. 32 found no relationship between depression and telomere shortening. The discrepancies between these studies could be explained by the fact that they included ...
5
Telomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A
... the telomere lengths of CD5 + CD19 + cells in MBL, CLL, and healthy ...groups. Telomere length was determined by qPCR. Telomere length was similar in the 3 study groups but shorter in these groups ...
4
Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length.
... of telomere length in Tasmanian devil and DFTD chromosomes, we performed quantitative fluorescent in situ hybridisation (Q-FISH) on meta- phase spreads from healthy devil cells, and cultured DFTD ...of ...
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Telomere biology in metazoa
... progressive telomere shortening occurs, eventually leading to senescence (Shay and Wright ...and telomere maintenance or elongation and immortalization (Bodnar, Ouellete et ...
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Mistranslation and telomere stability
... in telomere length as consequence of mistranslation, similar to those documented for SIR2 or PNC1 ...on telomere length, since non-mistranslating clones of strains lacking SIR2, PNC1 or both SIR2 and PNC1 ...
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