Tumor suppressor protein p53
Neurofibromatosis type 2 tumor suppressor protein, NF2, induces proteasome-mediated degradation of JC virus T-antigen in human glioblastoma.
... 2 protein (NF2) has been shown to act as tumor suppressor primarily through its functions as a cytoskeletal ...(JCV) tumor antigen (T-antigen) as a nuclear binding partner for NF2 in tumors ...
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Tumor suppressor p53 protein expression : prognostic significance in patients with lowrisk syndrome
... showed p53 expression in their bone ...express p53. Furthermore, patients express- ing p53 had a shorter median survival time compared to those without p53 ...of p53 at diagnosis is a ...
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Mechanisms that enhance sustainability of p53 pulses.
... The tumor suppressor p53 protein shows various dynamic responses depending on the types and extent of cellular ...repeated p53 pulses for recovery from DNA ...sustain p53 pulses ...
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Expression of p53 protein in pituitary adenomas
... a tumor suppressor gene, are associ- ated with abnormal cell ...Although p53 expression is common in many human malignancies, p53 protein has seldom been evaluated in pituitary ...of ...
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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.
... epithelial tumor cells after genotoxic stress in culture, and in epithelial tumor cells in vivo after treatment of prostate cancer patients with DNA- damaging ...the p53 tumor ...
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Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice.
... Most p53 mutations arise somatically during tumor development and ...er, p53 mutations can also be transmitted in the germ-line and give rise to cancer predisposi- tion conditions called Li-Fraumeni ...
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Myb-binding protein 1A (MYBBP1A) is essential for early embryonic development, controls cell cycle and mitosis, and acts as a tumor suppressor.
... MYBBP1A is a predominantly nucleolar transcriptional regulator involved in rDNA synthesis and p53 activation via acetylation. However little further information is available as to its function. Here we report that ...
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Detection of mutations within exons 4 to 8 of the p53 tumor suppressor gene in canine mammary glands
... mutant p53 protein has also been observed in canine tumors of epithelial, mesenchymal and round cell origins (Sagartz et ...of p53 assessed by real-time polymerase chain reaction (PCR), however, may ...
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Repositório Institucional UFC: Immunohistochemical expression of the tumor suppressor protein p16 INK4a in cervical adenocarcinoma
... with tumor suppressor proteins involved in the cell cycle, such as p53, and with those associated with proliferation, such as the retinoblastoma protein ...latter protein interacts with ...
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Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.
... of protein from each sample using 10 mg of anti-flag antibody. The protein complexes were analyzed on a 6% TBE non-denaturing polyacrylamide gel with a PageRuler Plus pre-stained ladder (Thermo scientific) ...
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Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms.
... Arf protein expression was confirmed by disrupting cells in RIPA buffer containing a protease inhibitor cocktail (Roche) and immunoblotting equal protein amounts with an antibody to19 Arf (5-C3, ...
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Structure and stability insights into tumour suppressor p53 evolutionary related proteins.
... the p53 family of proteins. It is known that the Homo sapiens p53 protein [18-22] consists of a central DNA-Binding domain (DBD), a tetramerization domain (TD), a trans-activation domain (TA) as well ...
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Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.
... measure tumor volume in murine retinoblastoma, none are useful to quantify small, developing tumors at very early time points ...quantitate tumor volume in the eyes of TAg-RB mice by analyzing every 60th ...
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A Bmi1-miRNAs cross-talk modulates chemotherapy response to 5-fluorouracil in breast cancer cells.
... liver tumor development [22] and for hedgehog pathway-driven medulloblastoma expansion ...the tumor suppressors p16INK4a and p19ARF (p14ARF in humans) [25], and PTEN to promote EMT (epithelial-mesenchymal ...
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Intragenic suppressor of Osiaa23 revealed a conserved tryptophan residue crucial for protein-protein interactions.
... of protein-protein interactions among these transcription factors, the mechanisms involved in these interactions are largely ...the protein-protein interactions between Osiaa23 and ...
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Braz. Dent. J. vol.16 número1
... presented p53 positive cell labeling, the mean labeling index being ...weak p53 labeling index, while the cases of AOT presented weak p53 labeling ...strongest p53 labeling index could be ...
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The novel fusion proteins, GnRH-p53 and GnRHIII-p53, expression and their anti-tumor effect.
... Purity of the GnRH-p53 and GnRH III-p53 was assessed by electrophoresis using 12% polyacrylamide gels with SDS Laemmli buffer followed by Commassie staining (Simply Blue SafeStain, Invitrogen). The bands ...
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DNA methylation analysis of the tumor suppressor gene CDKN2B
... of protein produc- tion is not uniform throughout the tumor-cell population, unlike the one that is produced by the genetic changes (Jones and Baylin, ...
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The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
... LKB1 protein is a serine-threonine kinase that phosphorylates AMP-activated protein kinase (AMPK) and other downstream ...LKB1 protein (and its absence) in mouse and human formalin-fixed, ...
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Avaliação da expressão imuno-histoquímica das proteínas p53 e pRB em ameloblastomas...
... de tumor odontogênico queratocístico foram incluídos no presente estudo respeitando os critérios de inclusão e exclusão elucidados em Material e ...de tumor odontogênico queratocístico uma maior predileção ...
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