Type I
Novel Clostridium thermocellum type I cohesin-dockerin complexes reveal a single binding mode
... of type I cohesin modules located in a non-catalytic molecular scaffold to type I dockerin mod- ules located at the C terminus of cellulosomal ...of type I dockerins display ...
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Schmallenberg virus infection of adult type I interferon receptor knock-out mice.
... Schmallenberg virus (SBV), a novel orthobunyavirus, was discovered in Europe in late 2011. It causes mild and transient disease in adult ruminants, but fetal infection can lead to abortion or severe malformations. There ...
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Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells.
... from Type II to Type I receptor-mediated apoptosis by SMO inhibition; SMO inhibition appears to mediate this switch by down-regulating XIAP gene ...independent, Type I ...converts ...
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Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency.
... Recently, we reported that a minor proportion of cells remain unresponsive even to high doses of type I interferon [24]. We speculated that MCMV infection of IFNb-unresponsive cells may generate sufficient ...
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Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence.
... potential. Type I interferon (IFN-I) then directly targets these newly generated DCs to pro- gram their potent T cell immunosuppressive functions while simultaneously inhibiting con- ventional DCs ...
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Chiari malformation type I: a case-control association study of 58 developmental genes.
... malformation type I (CMI) is a disorder characterized by hindbrain overcrowding into an underdeveloped posterior cranial fossa (PCF), often causing progressive neurological ...
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A Versatile Vector for In Vivo Monitoring of Type I Interferon Induction and Signaling.
... of type I interferon (IFN-I) pathways is of great interest in order to characterize biological responses to different inducers such as viral ...
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LPS regulates SOCS2 transcription in a type I interferon dependent autocrine-paracrine loop.
... The functional consequence of TLR activation of SOCS2 is incompletely understood. Though the SOCS family has been demonstrated to play a role as negative cytokine signaling regulators, the data from SOCS deficient mouse ...
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Putative monofunctional type I polyketide synthase units: a dinoflagellate-specific feature?
... of Type I and Type II KS domains from prokaryotic and eukaryotic PKS and ...representing Type I and Type II KS domains were retrieved from NCBI genbank, John et ...The ...
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Bridging the species divide: transgenic mice humanized for type-I interferon response.
... We have generated transgenic mice that harbor humanized type I interferon receptors (IFNARs) enabling the study of type I human interferons (Hu-IFN-Is) in mice. These ‘‘HyBNAR’’ (Hybrid IFNAR) ...
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Minimal type-I seesaw model with maximally restricted texture zeros
... For the phenomenologically viable textures, we have studied their implications for the BAU in the frame- work of type-I seesaw thermal leptogenesis. We paid special attention to the treatment of ...
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Identification of a type I nitroreductase gene in non-virulent Trypanosoma rangeli
... Type I nitroreductases (NTRs) are oxygen-insensi- tive oxidoreductases that contain flavin mononucleotide (FMN) as a ...eukaryotes, type I NTRs play an essential role in nitro- drug activation ...
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Endogenous and recombinant type I interferons and disease activity in multiple sclerosis.
... We conclude that the modulation of CD49d and other molecules on CD4+CD26high T cells may be one of the most important effects of IFN-b in MS, and may also be mediated by endogenous type I IFN activity. ...
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Giant intrathoracic meningoceles associated with cutaneous neurofibromatosis type I: case report
... neurofibromatosis type I and with a few cases related in the ...neurofibromatosis type I is rare and is probably unique in the literature the presence of 4 huge cysts in one side of the ...
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Collagen type I alpha 1 gene polymorphism in premature ovarian failure
... The essential task of BMD measurements is to identify women with POF at increased risk for osteoporosis, thereby enabling appropriate treatment. This is the first study to in- vestigate COLIA1 gene polymorphism in women ...
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Anterior segment optical coherence tomography findings in type I Boston keratoprosthesis
... FP= front plate; S= stem; BP= back plate; BCL= bandage contact lens. Figure 2. AS-OCT of a type I Boston KPro-implanted eye demonstrating gaps between the carrier donor cornea and the stem of the KPro ...
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Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice.
... women, type I (insulin-dependent) diabetes has been linked to complications during pregnancy, often resulting in miscarriage, embryonic developmental abnormalities and congenital malforma- tions ...
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Familial hyperaldosteronism type I
... hyperaldosteronism type II (FH-II), so named to distinguish the disorder from GRA or familial hyperaldosteronism type I (FH-I), is characterised by autosomal domi- nant inheritance of ...
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Caspase-3 activation and increased procollagen type I in irradiated hearts
... proc type I (Santa Cruz Biotechnology, CA, USA), TGF-β1 (Santa Cruz Biotechnology), pro-caspase-3 (Santa Cruz Biotechnology, CA, USA) and α-tubulin (Clone b- 5-1-1 mouse) (Sigma Aldrich) were in dilutions ...
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Type I interferon: potential therapeutic target for psoriasis?
... of type I IFN–inducible genes in psoriasis, we first carried out ex vivo stimulation of healthy donor whole blood and in vitro stimulation of normal human keratinocytes with different members of the ...
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