Zoledronic acid
Effect of zoledronic acid used in the root surface treatment of late replanted teeth: A study in rats
... of zoledronic acid ...Additionally, zoledronic acid acts only on clasts, which specifies its action ...of zoledronic acid in inhibiting the resorptive process (14,19,20), in the ...
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Zoledronic acid enhances lipopolysaccharide-stimulated proinflammatory reactions through controlled expression of SOCS1 in macrophages.
... Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious side effect of nitrogen-containing bisphosphonate (NBP) use. Many studies have shown that BRONJ is limited to the jawbone and does not occur in the ...
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Assessment of the Impact of Zoledronic Acid on Ovariectomized Osteoporosis Model Using Micro-CT Scanning.
... 39]. Zoledronic acid is a potent anti-resorptive agent which has been approved for the treatment of various dis- orders characterized by increased osteoclast-mediated bone resorption, such as estrogen ...
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Detecting early biomechanical effects of zoledronic acid on femurs of osteoporotic female rats
... Zoledronic acid was selected in this study due to its high rates of positive bone balance with only one annual dose, decreasing patients’ noncompliance with the treatment [19, ...
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Cytotoxic Effects of Zoledronic Acid on Human Epithelial Cells and Gingival Fibroblasts
... of zoledronic acid (ZA), a nitrogen-containing bisphosphonate, is the highest concentration of this drug found in the oral cavity of patients under ...
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Chronic treatment with zoledronic acid increases inflammatory markers in periodontium of rats
... Background: Bisphosphonates (BF) rise proinflammatory markers and irreversibly bind to bone. Chronically, BF can lead to an inflammatory status and can increase the local oxidative stress in periodontium. Therefore, the ...
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Effects of zoledronic acid on odontoblast-like cells
... The aim of the study was to evaluate the effects of a highly potent bisphosphonate, zoledronic acid (ZOL), on cultured odontoblast-like cells MDPC-23. The cells (1.5 10 4 cells/cm 2 ) were seeded for 48 h ...
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The influence of menopausal status on bone turnover and disease control in breast cancer patients with metastatic bone disease treated with chemotherapy plus zoledronic acid: an exploratory retrospective cohort study
... As referred before, most of the available clinical evidence of the anti-tumor action of BPs is derived from trials that used zoledronic acid; however, other BPs were also tested. The NSABP B-34 tested the ...
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Immune cell profile of dental pulp tissue treated with zoledronic acid
... Zoledronic acid (ZA) is a third-generation amino- bisphosphonate. It is an analogue of endogenous pyrophosphate and has an antiresorptive power more than 1000 times greater than that of etidronate, the ...
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Rev. Assoc. Med. Bras. vol.57 número1
... 7. Coleman RE, Winter MC, Cameron D, Bell R, Dodwell D, Keane MM et al. he efects of adding zoledronic acid to neoadjuvant chemother- apy on tumour response: exploratory evidence for direct anti-tumour ...
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Rev. Assoc. Med. Bras. vol.57 número1 en v57n1a04
... of zoledronic acid for prevention of aro- matase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant ...
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Braz. Dent. J. vol.27 número5
... osteoporosis.(1,2) Zoledronic acid is a potent and innovative third- generation nitrogen-containing biphosphonate that is administered intravenously with rapid absorption and concentration in the maxillary ...
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Int. braz j urol. vol.34 número1
... Methods: Serum measurements of total alkaline phosphatase (tALP), bone-specific alkaline phosphatase (bALP), cross-linked N-terminal (NTx) and cross-linked C-terminal (CTx) telopeptides of type I collagen, amino-terminal ...
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Rev. Hosp. Clin. vol.59 número5
... words, zoledronic acid, osteoporosis, and children, in the title, keywords, and abstracts and could not find another published case in which the zoledronic acid was used in a child or an ...
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Osseointegration of biochemically modified implants in an osteoporosis rodent model
... Sandblasted, acid-etched titanium implants were either used directly (control) or were further modiied by surface conditioning with NaOH or by coating with one of the following active agents: collagen/chondroitin ...
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Expressão de marcadores inflamatórios na osteonecrose dos maxilares induzida por bisfosfonatos e efeito do tratamento crônico com ácido zoledrônico nos tecidos gengival e ósseodentário de ratos
... Introduction: The Zoledronic Acid (ZA) is a bisphosphonate (BF) that can lead to immune- inflammatory dysregulation leading to Bisphosphonate-related Osteonecrosis of the Jaws ([r] ...
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Int. braz j urol. vol.34 número3
... Interleukin-6 (IL-6) is an important regula- tor of cellular events in human prostate cancer. It has multifunctional effects on proliferation, apoptosis, and angiogenesis and is a target for novel therapies. Most studies ...
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Análise da microbiota de feridas cirúrgicas em maxilas de ratos sob terapia com bisfosfonatos
... 4,6,7 Zoledronic acid is a potent nitrogen-containing bisphosphonate most used to treat bone metastases, whereas clodronate, also used for this purpose, belongs to the non-nitrogen-containing ...
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Braz. Dent. J. vol.26 número1
... The prevalence of ONJ in patients with malignant disease is considerably higher than in patients with benign diseases such as osteopathies, osteoporosis, Paget’s disease, and hypercalcemia of any cause. Dentoalveolar ...
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Avaliação macro e microscópica de lesões orais induzidas por procedimentos cirúrgicos em ratos sob terapia com bisfosfonatos
... and zoledronic acid effect on the repair of surgical wounds induced by tooth extraction and oral soft tissue ...with zoledronic acid; (2) 12 animals treated with clodronate; and (3) 10 animals ...
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