[PDF] Top 20 A receptor for infectious and cellular prion protein
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A receptor for infectious and cellular prion protein
... of infectious agents composed only of protein and involved in transmissible spongiform encephalopathies in humans and ...The infectious particle is composed by PrPsc which is an isoform ... See full document
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Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype.
... The cellular prion protein (PrP C ) has been proposed to play an important role in the patho- genesis of Alzheimer’s ...In cellular models PrP C inhibited the action of the β-secre- tase BACE1 ... See full document
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Manganese enhances prion protein survival in model soils and increases prion infectivity to cells.
... of protein adsorption on to soil particles is far from straight ...pH and constituents and protein PI, conformation, size, charge, solubility and flexibility ...(kte) and ... See full document
9
Annexin A2: The Importance of Being Redox Sensitive
... N- and C-terminal regions ...(Tyr-23) and protein kinase C (Ser-11, Ser-25) [50,51] and a nuclear export signal (NES) [52], while the C-terminal region contains a reactive cysteine residue ... See full document
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Dopamine induces the accumulation of insoluble prion protein and affects autophagic flux
... ischemia and antioxidant defense mechanisms appear to require PrP C expression (McLennan et ...C and ROS have also been proposed (Bertuchi et ...neurons and has flexible N-terminal domain enriched by ... See full document
11
Recombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivity.
... of prion infectivity spontaneously generated in vitro using rPrP have been reported ...heat and bovine serum albumin [12] or used as a substrate in PMCA [13] yielded low levels of hamster prion ... See full document
15
Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum.
... direct and indirect pathway neurons were made on the same ...neurons and multiple neurons lacking either ChAT or PV label (considered medium spiny ...direct and indirect pathway striatal neurons at ... See full document
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Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells
... Two cellular systems, where the expression of PrP changes very significantly, were used to identify proteins and GO categories possibly related to the function of ...the prion protein in the ... See full document
13
Volume and energy folding landscape of prion protein revealed by pressure
... the protein during ...pressure and dissociated at pressures below 400 MPa (Figure ...turants and also reported that newly formed aggregates are less hydrated and have more cavities than native ... See full document
7
Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli.
... scraped and homogenized in lysis buffer containing 50 mM Tris-HCl, ...X-100 and 0.5% sodium deoxycholate. Equal amounts of protein (40 m g) were separated on sodium dodecyl sulfate polyacrylamide gel ... See full document
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Live-cell FRET imaging reveals clustering of the prion protein at the cell surface induced by infectious prions
... PrP-CFP-GPI and other regions richer in ...nuclei and ER labeling using the fluorophores Hoechst 33342 and ER-tracker red (Molecular Probes), respectively ...microscopy and single molecule ... See full document
11
Prion protein expression regulates embryonic stem cell pluripotency and differentiation.
... Cellular prion protein (PRNP) is a ubiquitous membrane glycoprotein whose abnormal self-replicating, misfolded form is widely believed to cause several central nervous system disorders, collectively ... See full document
12
Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep.
... sheep and goat caused by prions, has been intensively studied for more than a century ...iatrogenic and variant etiology, chronic wasting disease (CWD) of deer, elk, and moose, and a variety ... See full document
8
NCAM1 Polysialylation
... the prion protein sequence that replaces an aspartate with an asparagine residue at Position 178 on a background of the common methionine or methio- nine polymorphism at PrP C amino acid Position ...humans ... See full document
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Cell type-specific neuroprotective activity of untranslocated prion protein.
... inhibitors and staurosporine, which activate the intrinsic apoptotic pathway ...cortical and hippocampal cells, but not in cerebellar granules where CAM741 induced ...cytosol and mediate ... See full document
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PrionHome: a database of prions and other sequences relevant to prion phenomena.
... the protein that forms the [URE3] prion, produces some interesting ...the protein that forms the [URE3] prion, is ...G-protein-coupled receptor GPR1, which was shown, via the ... See full document
11
Neurotoxicity of prion peptides mimicking the central domain of the cellular prion protein.
... neuronal and glial populations of the telencephalon ...(OR) and a central domain (CD) ...95–110) and the hydrophobic core (HR, residues 112–133), which makes up the first transmembrane domain (TM1) ... See full document
11
The cellular prion protein negatively regulates phagocytosis and cytokine expression in murine bone marrow-derived macrophages.
... femurs and tibiae of 6- to 8-week-old female ZrchI type PRNP 2/2 mice [22] and wild- type C57BL/6 mice (Vital River Laboratory Animal Technology, Beijing, ...Welfare and Ethics of Laboratory Animals ... See full document
9
Insights into the physiological function of cellular prion protein
... There is increasing evidence supporting a functional role for PrPc in copper metabo- lism. Several studies have indicated that PrPc can bind copper. First, it was possible to isolate PrPc from hamster brain on a copper ... See full document
11
Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain.
... AD and prion ...the cellular prion protein can act as a receptor for Ab, with Ab oligomers binding to PrP C with high affinity, although there are conflicting views as to the ... See full document
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