... 7-like 2 (TCF7L2) is associated with type2diabetes mellitus (T2DM) in multiple ethnic groups, especially its single nucleotide polymorphisms of rs7903146C/T, ...
... genotype of rs878081 poly- morphism significantly decreased the AIRE expression, many researchers focused on theassociationbetween AIRE rs878081 polymorphismand RA ...
... (HWE) of each SNP was tested by the goodness-of-fit x 2 test to compare the expected frequencies of genotypes in controls, SNPs with ...be in HWE [22]. The ...
... demonstrated the potential associationbetween other XRCC1 genetic variants andthe risk of EC (for example, Arg194Trp, Arg280His, and ...that the Arg194Trp genetic ...
... Haplotype analysis revealed that the haplotype GGCG conferred a reduced risk of SLE, whereas GGTG was associated with susceptibility to ...analyzing the results presented in Table ...
... using the created restric- tion site-PCR (CRS-PCR) method with one ofthe primers containing a nucleotide mismatch, which enables the use of restriction enzymes for discriminating ...
... from the patients and controls, and stored at 280uC. The frozen samples were thawn and centrifuged at 50006g for 15 min, andthe upper layer was removed and ...
... by the transcription factor 2gene (TCF2), plays a critical role in pancreatic cell formation and glucose ...(SNPs) of TCF2 are associated with susceptibility to type ...
... overexpression ofthe elongation of long-chain fatty acids family member 6 (Elovl6) gene can cause insulin resistance and b-cell ...are the major factors involved in ...
... Despite the clear strengths of our study including relatively large sample sizes and robustness of statistical analyses, interpretation of our current study, however, should be viewed ...
... However, in this meta-analysis, we did not find any obvious heterogeneity and publish bias across ...plot and Egger’s test show no publication bias, selection bias could have occurred ...
... for the potential eligible articles in English andChineseinthe following database: (1) Medline in PubMed searching engine; (2) Embase database; (3) Chi- nese ...
... increase in obesity prevalence, which is recently also being observed in developing ...prevalence of hypertension, stroke, coronary artery disease, andtype2diabetes ...
... Pickering and colleagues have initially suggested that hyperten- sion and blood pressure are complex traits [33], and previous epidemiologic studies have found dozens of risk factors, such as ...
... mRNA and soluble expression in knee OA patients. However, the TNF-a rs1800629 genotypes did not show statistical difference between cases and con- ...trols. In addition, ...
... 5–7% of women of childbearing age ...clinical and/or biochem- ical hyperandrogenism, and polycystic ovarian morphology on ultrasound ...number of women with PCOS also exhibit insulin ...
... limitations of this meta-analysis should be acknowledged. Because ofthe absence of detailed information about BMI, age, and gender in some studies, we did our ...