[PDF] Top 20 The association between gene polymorphism of TCF7L2 and type 2 diabetes in Chinese Han population: a meta-analysis.

... 7-like 2 (TCF7L2) is associated with type 2 diabetes mellitus (T2DM) in multiple ethnic groups, especially its single nucleotide polymorphisms of rs7903146C/T, ... See full document

... genotype of rs878081 poly- morphism significantly decreased the AIRE expression, many researchers focused on the association between AIRE rs878081 polymorphism and RA ... See full document

... (HWE) of each SNP was tested by the goodness-of-fit x 2 test to compare the expected frequencies of genotypes in controls, SNPs with ...be in HWE [22]. The ... See full document

... Obesity and type 2 diabetes are highly prevalent worldwide ...to type 2 diabetes ...to the risk for type 2 diabetes ...A of SNP ... See full document

... 2008. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 ... See full document

... demonstrated the potential association between other XRCC1 genetic variants and the risk of EC (for example, Arg194Trp, Arg280His, and ...that the Arg194Trp genetic ... See full document

... Haplotype analysis revealed that the haplotype GGCG conferred a reduced risk of SLE, whereas GGTG was associated with susceptibility to ...analyzing the results presented in Table ... See full document

... using the created restric- tion site-PCR (CRS-PCR) method with one of the primers containing a nucleotide mismatch, which enables the use of restriction enzymes for discriminating ... See full document

... from the patients and controls, and stored at 280uC. The frozen samples were thawn and centrifuged at 50006g for 15 min, and the upper layer was removed and ... See full document

... by the transcription factor 2 gene (TCF2), plays a critical role in pancreatic cell formation and glucose ...(SNPs) of TCF2 are associated with susceptibility to type ... See full document

... overexpression of the elongation of long-chain fatty acids family member 6 (Elovl6) gene can cause insulin resistance and b-cell ...are the major factors involved in ... See full document

... Despite the clear strengths of our study including relatively large sample sizes and robustness of statistical analyses, interpretation of our current study, however, should be viewed ... See full document

... However, in this meta-analysis, we did not find any obvious heterogeneity and publish bias across ...plot and Egger’s test show no publication bias, selection bias could have occurred ... See full document

... for the potential eligible articles in English and Chinese in the following database: (1) Medline in PubMed searching engine; (2) Embase database; (3) Chi- nese ... See full document

... increase in obesity prevalence, which is recently also being observed in developing ...prevalence of hypertension, stroke, coronary artery disease, and type 2 diabetes ... See full document

... variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus ...(T2DM). The aim was to ... See full document

... Pickering and colleagues have initially suggested that hyperten- sion and blood pressure are complex traits [33], and previous epidemiologic studies have found dozens of risk factors, such as ... See full document

... mRNA and soluble expression in knee OA patients. However, the TNF-a rs1800629 genotypes did not show statistical difference between cases and con- ...trols. In addition, ... See full document

... 5–7% of women of childbearing age ...clinical and/or biochem- ical hyperandrogenism, and polycystic ovarian morphology on ultrasound ...number of women with PCOS also exhibit insulin ... See full document

... limitations of this meta-analysis should be acknowledged. Because of the absence of detailed information about BMI, age, and gender in some studies, we did our ... See full document